A5040744360- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Long-Term Effects of COVID-19
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
- Intensive Care Unit Cognitive Disorders
- SARS-CoV-2 and COVID-19 Research
- Traumatic Brain Injury Research
- Hemodynamic Monitoring and Therapy
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- COVID-19 and healthcare impacts
- Advanced Chemical Sensor Technologies
- Emergency and Acute Care Studies
- Infective Endocarditis Diagnosis and Management
- SARS-CoV-2 detection and testing
- Family and Patient Care in Intensive Care Units
- Cardiovascular Health and Disease Prevention
- Non-Invasive Vital Sign Monitoring
- Airway Management and Intubation Techniques
University of Manchester
2015-2025
Salford Royal NHS Foundation Trust
2016-2025
Salford Royal Hospital
2012-2025
Manchester Academic Health Science Centre
2010-2024
Imperial College London
2021-2024
Northern Health and Social Care Trust
2020-2024
NIHR Manchester Biomedical Research Centre
2019-2023
National Institute for Health Research
2019-2023
Roslin Institute
2022-2023
University of Edinburgh
2022-2023
The Faculty of Intensive Care Medicine and Society Guideline Development Group have used GRADE methodology to make the following recommendations for management adult patients with acute respiratory distress syndrome (ARDS). British Thoracic supports in this guideline. Where mechanical ventilation is required, use low tidal volumes (<6 ml/kg ideal body weight) airway pressures (plateau pressure <30 cmH
<h3>Importance</h3> Continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO) have been recommended for acute hypoxemic respiratory failure in patients with COVID-19. Uncertainty exists regarding the effectiveness safety of these noninvasive strategies. <h3>Objective</h3> To determine whether either CPAP or HFNO, compared conventional therapy, improves clinical outcomes hospitalized COVID-19–related failure. <h3>Design, Setting, Participants</h3> A parallel group,...
COVID-19 pathogenesis is associated with an exaggerated immune response. However, the specific cellular mediators and inflammatory components driving diverse clinical disease outcomes remain poorly understood. We undertook longitudinal profiling on both whole blood peripheral mononuclear cells (PBMCs) of hospitalized patients during peak pandemic in UK. Here, we report key signatures present shortly after hospital admission that were severity COVID-19. Immune related to shifts neutrophil T...
Abstract Background Participants in clinical research studies often do not reflect the populations for which healthcare interventions are needed or will be used. Enhancing representation of under-served groups is important to ensure that findings widely applicable. We describe a multicomponent workstream project improve trials. Methods The comprised three main strands: (1) targeted scoping review literature identify previous work characterising and barriers inclusion, (2) surveys...
BackgroundEmerging studies indicate that some coronavirus disease 2019 (COVID-19) patients suffer from persistent symptoms, including breathlessness and chronic fatigue; however, the long-term immune response in these presently remains ill-defined.MethodsHere, we describe phenotypic functional characteristics of B T cells hospitalized COVID-19 during acute at 3–6 months convalescence.FindingsWe report alterations cell subsets observed were largely recovered convalescent patients. In...
Introduction. During previous viral pandemics, reported co-infection rates and implicated pathogens have varied. In the 1918 influenza pandemic, a large proportion of severe illness death was complicated by bacterial co-infection, predominantly Streptococcus pneumoniae Staphylococcus aureus . Gap statement. A better understanding incidence in patients with COVID-19 infection involved is necessary for effective antimicrobial stewardship. Aim. To describe nature critically ill adults England....
BackgroundVentilator-associated pneumonia is the most common intensive care unit (ICU)-acquired infection, yet accurate diagnosis remains difficult, leading to overuse of antibiotics. Low concentrations IL-1β and IL-8 in bronchoalveolar lavage fluid have been validated as effective markers for exclusion ventilator-associated pneumonia. The VAPrapid2 trial aimed determine whether measurement could effectively safely improve antibiotic stewardship patients with clinically suspected...
Traumatic brain injury (TBI) is a significant cause of disability, but little known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, broad range care pathways, treatment characteristics, outcomes following mild moderate/severe performed mixed-effects regression analyses in prospective multi-center Collaborative European NeuroTrauma Effectiveness Research Brain Injury (CENTER-TBI) study, stratified for severity age, adjusted baseline...
During an infectious disease outbreak, biases in the data and complexities of underlying dynamics pose significant challenges mathematically modelling outbreak designing policy. Motivated by ongoing response to COVID-19, we provide a toolkit statistical mathematical models beyond simple SIR-type differential equation for analysing early stages assessing interventions. In particular, focus on parameter estimation presence known data, effect non-pharmaceutical interventions enclosed...
<h3>Importance</h3> A head computed tomography (CT) with positive results for acute intracranial hemorrhage is the gold-standard diagnostic biomarker traumatic brain injury (TBI). In moderate to severe TBI (Glasgow Coma Scale [GCS] scores 3-12), some CT features have been shown be associated outcomes. mild (mTBI; GCS 13-15), distribution and co-occurrence of pathological their prognostic importance are not well understood. <h3>Objective</h3> To identify adverse outcomes after mTBI....
Complex metabolic disruption is a crucial aspect of the pathophysiology traumatic brain injury (TBI). Associations between this and systemic metabolism their potential prognostic value are poorly understood. Here, we aimed to describe serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, its relationship severity patient outcome. We performed comprehensive metabolomics study in cohort 716 patients non-TBI reference (orthopedic, internal medicine, other...
Age and comorbidities increase COVID-19 related in-hospital mortality risk, but the extent by which mediate impact of age remains unknown.In this multicenter retrospective cohort study with data from 45 Dutch hospitals, 4806 proven patients hospitalized in hospitals (between February July 2020) CAPACITY-COVID registry were included (age 69[58-77]years, 64% men). The primary outcome was defined as a combination or discharge palliative care. Logistic regression analysis performed to analyze...
Abstract Background While the Glasgow coma scale (GCS) is one of strongest outcome predictors, current classification traumatic brain injury (TBI) as ‘mild’, ‘moderate’ or ‘severe’ based on this fails to capture enormous heterogeneity in pathophysiology and treatment response. We hypothesized that data-driven characterization TBI could identify distinct endotypes give mechanistic insights. Methods developed an unsupervised statistical clustering model a mixture probabilistic graphs for...
Limited evidence existed on the comparative effectiveness of decompressive craniectomy (DC) versus craniotomy for evacuation traumatic acute subdural hematoma (ASDH) until recently published randomised clinical trial RESCUE-ASDH. In this study, that ran concurrently, we aimed to determine current practice patterns and compare outcomes primary DC craniotomy.We conducted an analysis centre treatment preference within prospective, multicentre, observational Collaborative European NeuroTrauma...
Background COVID-19 is associated with a dysregulated immune response but it unclear how dysfunction contributes to the chronic morbidity persisting in many patients during convalescence (long COVID). Methods We assessed phenotypical and functional changes of monocytes hospitalisation up 9 months following COVID-19, respiratory syncytial virus or influenza A. Patients progressive fibrosing interstitial lung disease were included as positive control for severe, ongoing injury. Results...