A5083934289- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- ECG Monitoring and Analysis
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Ion channel regulation and function
- Heart Rate Variability and Autonomic Control
- Cardiomyopathy and Myosin Studies
- COVID-19 Clinical Research Studies
- Non-Invasive Vital Sign Monitoring
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Frailty in Older Adults
- Cardiovascular Function and Risk Factors
- COVID-19 and healthcare impacts
- Schizophrenia research and treatment
- Takotsubo Cardiomyopathy and Associated Phenomena
- Receptor Mechanisms and Signaling
- Cardiovascular Syncope and Autonomic Disorders
- Neuroscience of respiration and sleep
Maastricht University
2013-2025
University Medical Center
2015-2025
Maastricht University Medical Centre
2015-2025
Cardiovascular Institute Hospital
2020-2025
ERN GUARD-Heart
2023
Age and comorbidities increase COVID-19 related in-hospital mortality risk, but the extent by which mediate impact of age remains unknown.In this multicenter retrospective cohort study with data from 45 Dutch hospitals, 4806 proven patients hospitalized in hospitals (between February July 2020) CAPACITY-COVID registry were included (age 69[58-77]years, 64% men). The primary outcome was defined as a combination or discharge palliative care. Logistic regression analysis performed to analyze...
Abstract Aims The optimal substrate ablation approach for post-myocardial infarction (MI) ventricular tachycardia (VT) is unknown. Proposed targets are prone to individual interpretation making the outcome potentially operator dependent. Evoked delayed potentials (EDPs) a well-defined target. potential was effective in preventing post-MI VT recurrence prior study. aims of this study were assess long-term outcomes EDP large multicentre cohort patients and compare between centres with without...
Prolonged and dispersed left-ventricular (LV) contraction is present in patients with long-QT syndrome (LQTS). Electrical mechanical abnormalities appear most pronounced symptomatic individuals. We focus on the 'electromechanical window' (EMW; duration of LV-mechanical systole minus QT interval) genotyped LQTS. Profound EMW negativity heralds torsades de pointes animal models drug-induced included 244 LQTS from three centres, whom 97 had experienced arrhythmic events. Seventy-six matched...
Premature beats originating in clinically concealed areas of local early repolarization promote ventricular arrhythmias and sudden cardiac arrest.
Implantation of a permanent pacemaker and atrioventricular (AV) node ablation (pace-and-ablate) is an established approach for rate symptom control in elderly patients with symptomatic atrial fibrillation (AF). Left bundle branch area pacing (LBBAP) physiological strategy that might overcome right ventricular pacing-induced dyssynchrony. In this study, the feasibility safety performing LBBAP AV single procedure was investigated.Consecutive AF referred pace-and-ablate underwent treatment...
Highlights•Strain echocardiography can detect altered myocardial mechanics in patients with AS.•Pronounced mechanical dispersion is associated worse prognosis AS.•Mechanical adds incremental prognostic value to LVEF, atrioventricular impedance, and global longitudinal strain.•Mechanical predicts mortality independently of LVEF AVR surgery status.AbstractBackgroundIn aortic stenosis, subtle alterations be detected by speckle-tracking before reduction left ventricular ejection fraction...
Continuous progress in atrial fibrillation (AF) ablation techniques has led to an increasing number of procedures with improved outcome. However, about 30-50% patients still experience recurrences within 1 year after their ablation. Comprehensive translational research approaches integrated clinical care pathways may improve our understanding the complex pathophysiology AF and patient selection for ablation.Within "IntenSive mOlecular eLectropathological chAracterization patienTs undergoIng...
Sudden cardiac death is often caused by ventricular arrhythmias driven reentry. Comprehensive characterization of the potential triggers and substrate in survivors sudden arrest has provided insights into trigger-substrate interaction leading to Previously, a “Triangle Arrhythmogenesis”, reflecting interactions between substrate, trigger modulating factors, been proposed reason about arrhythmia initiation. Here, we expand upon this concept separating characteristics their spatial temporal...
Abstract Background The short-QT syndrome (SQTS) is a rare cardiac disorder associated with abnormally short repolarization duration and increased risk of ventricular tachyarrhythmia (VT). In-vivo depolarization patterns in patients SQTS are unknown. Purpose First characterization epicardial using noninvasive ECG imaging (ECGi). Methods ECGi was performed 54-year-old male patient (QTc 318 ms, inferolateral J-wave elevation, score 4, no causal mutation identified) history syncope long-coupled...
Abstract Background Heart failure with preserved ejection fraction (HFpEF) often coexists atrial fibrillation (AF), but diagnosing HFpEF in patients AF can be challenging as some diagnostic criteria may more related to itself than HFpEF. Purpose This study aimed evaluate (1) the prevalence of based on left pressure (LAP) measurements undergoing ablation; (2) predictors HFpEF; (3) concordance between LAP and risk scores; (4) impact heart rhythm, ventilation type during ablation, values....
Abstract Background/Introduction Idiopathic ventricular fibrillation (VF) and polymorphic tachycardia (pVT) are often triggered by short-coupled premature complexes (SC-PVCs), with coupling intervals (CI) <350 ms. However, the timing, burden, conditions of these PVCs remain largely unknown. Purpose To investigate CIs burden (SC-)PVCs in idiopathic VF/pVT survivors, their relation to time since last event (i.e., episodes, appropriate ICD shocks, or antitachypacing), compare...
Abstract Background Beta-blockers are the first-line therapy for patients with long QT syndrome (LQTS), resulting in a significant reduction mortality. Non-selective beta-blockers superior to cardio-selective preventing arrhythmic events. However, it is unclear how therapeutic efficacy should be monitored. Frequently used parameters such as QTc do not always adequately reflect arrhythmogenic risk. Previously, we have demonstrated that Tpeak/end - marker transmural heterogeneity and delta...
Abstract Background Catheter ablation (CA) has been established as an effective therapeutic option to achieve rhythm control in patients with atrial fibrillation (AF). However, AF recurrence occurs approximately one-third of the undergoing CA. The association between after CA and left (LA) strain, which is a surrogate marker LA mechanical dysfunction already appearing before enlargement LA, remains less clear. Aim purpose this study was evaluate function assessed by strain echocardiography...
Abstract Background Arrhythmogenesis in long-QT syndrome (LQTS) is driven by electrical instabilities, proarrhythmic electromechanical reciprocity, and swift autonomic nervous system (ANS) fluctuations. Purpose Characterizing the substrate LQTS patients without with previous ventricular tachyarrhythmia (VT). Methods prospectively underwent simultaneous non-invasive ECG imaging (ECGi), echocardiography, provocation testing epinephrine (Epi; Mayo Clinic protocol), 24h-Holter. Electromechanical...
Abstract Background Torsades de pointes (TdP) is a potentially lethal ventricular tachyarrhythmia occuring in congenital long-QT syndrome or acquired QT prolongation. Trigger mechanisms of TdP the beating heart are still poorly understood, but electromechanical reciprocity likely contributes. Purpose (1.) Determining timing left-ventricular (LV) mechanical events at induction large animal model, particularly impact LV filling; (2.) Delaying onset filling with myosin activator omecamtiv...
Abstract Aims During the diagnostic work-up of patients with idiopathic ventricular fibrillation (VF), next-generation sequencing panels can be considered to identify genotypes associated arrhythmias. However, consensus for gene panel testing is still lacking, and variants uncertain significance (VUS) are often identified. The aim this study was evaluate genetic its results in VF patients. Methods We investigated 419 available medical records from Dutch Idiopathic Registry. Genetic performed...