A5100706208- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiomyopathy and Myosin Studies
- Ovarian function and disorders
- Regulation of Appetite and Obesity
- Olfactory and Sensory Function Studies
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Cardiovascular Effects of Exercise
- Advanced Chemical Sensor Technologies
- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- Viral Infections and Immunology Research
- Muscle metabolism and nutrition
- Gestational Diabetes Research and Management
- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Heart Failure Treatment and Management
- Metabolomics and Mass Spectrometry Studies
- Cardiac Fibrosis and Remodeling
- Bone Metabolism and Diseases
- Autophagy in Disease and Therapy
- Cardiovascular Disease and Adiposity
- Diabetes Treatment and Management
Shaoxing People's Hospital
2025
Shandong University
2024
South China Agricultural University
2024
Hainan Medical University
2018-2024
Xi'an Shiyou University
2023
Shandong Provincial QianFoShan Hospital
2023
Shandong First Medical University
2023
Maastricht University Medical Centre
2012-2022
Maastricht University
2008-2022
First Affiliated Hospital of Xi'an Jiaotong University
2021
Obesity is one of the most important modifiable risk factors for prevention type 2 diabetes. The aim this study was to examine prevalence diabetes with increasing severity obesity and distribution HbA1c levels in diabetics participating latest National Health Nutrition Examination Survey (NHANES).Data from a representative sample adults NHANES between 1999 2006 were reviewed. fasting glucose, insulin, c-peptide, examined across different weight classes normal weight, overweight, 1, 2, 3...
BACKGROUND: In a prospective observational study of 42 pregnancies in 39 Caucasian women (age 30 ± 4 years) with polycystic ovary syndrome (PCOS), we examined effects metformin on maternal insulin, insulin resistance (IR), secretion (IS), weight gain, development gestational diabetes (GD), testosterone and plasminogen activator inhibitor activity. We assessed the hypothesis that diet–metformin (MET) lessens physiological increase IR reduces thus reducing GD. METHODS: Preconception, an...
Abstract The specificity of proteins identified by proteomics as biomarkers for defined conditions or components biological processes and pathways is crucial. We critically reviewed differentially expressed from comparative proteomic studies 2‐DE followed MS, especially with MALDI technique. Based on 66 those studies, a list 44 presented generally detected regardless species, in vivo vitro conditions, tissues organs, experimental objective. Similarly, 28 protein families presented. enriched...
Abstract Primary ovarian insufficiency (POI) is a common cause of infertility in around 1–2% women aged <40 years. However, the mechanisms that POI are still poorly understood. Here we showed germ cell-specific knockout an essential autophagy induction gene Atg7 led to subfertility female mice. The deletion females was caused by severe follicle loss, which very similar human patients. Further investigation revealed resulted cell over-loss at neonatal transition period. In addition, our...
Abstract Aims The dilated cardiomyopathy (DCM) phenotype is the result of combined genetic and acquired triggers. Until now, clinical decision-making in DCM has mainly been based on ejection fraction (EF) NYHA classification, not considering heterogenicity. present study aimed to identify patient subgroups by phenotypic clustering integrating aetiologies, comorbidities, cardiac function along transcript levels, unveil pathophysiological differences between subgroups. Methods results We...
Genetic analysis is a first-tier test in dilated cardiomyopathy (DCM). Electrical phenotypes are common genetic DCM, but their exact contribution to the clinical course and outcome unknown. We determined prevalence of pathogenic gene variants large unselected DCM population role electrical association with outcome.This study included 689 patients from Maastricht Cardiomyopathy Registry, undergoing evaluation using 48 cardiomyopathy-associated gene-panel, echocardiography, endomyocardial...
Background Identifying the mechanistic pathways potentially associated with incident heart failure (HF) may provide a basis for novel preventive strategies. Methods and Results To identify proteomic biomarkers potential underlying that be HF defined as first hospitalization HF, nested-matched case-control design was used cases (incident HF) controls (without selected from 3 cohorts (>20 000 individuals). Controls were matched on cohort, follow-up time, age, sex. Two independent sample sets...
Age and comorbidities increase COVID-19 related in-hospital mortality risk, but the extent by which mediate impact of age remains unknown.In this multicenter retrospective cohort study with data from 45 Dutch hospitals, 4806 proven patients hospitalized in hospitals (between February July 2020) CAPACITY-COVID registry were included (age 69[58-77]years, 64% men). The primary outcome was defined as a combination or discharge palliative care. Logistic regression analysis performed to analyze...
Abstract Aims To determine the prognostic value of multilevel assessment fibrosis in dilated cardiomyopathy (DCM) patients. Methods and results We quantified 209 DCM patients at three levels: (i) non‐invasive late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR); (ii) blood biomarkers [amino‐terminal propeptide procollagen type III (PIIINP) carboxy‐terminal I (PICP)], (iii) invasive endomyocardial biopsy (EMB) (collagen volume fraction, CVF). Both LGE elevated PICP levels, but...
Abstract Background: Health education has been considered as the effectiveness method to increase self-care skills of diabetes patients. However, limited studies investigate association health via Wechat platform on increased basic and glycemic control rate in patients with type 2 diabetes. Methods: A total number 120 were randomized into intervention (health by plus usual care) group (usual care). Biochemical parameters including fasting plasma glucose (FPG), 2-hour (2hPG), glycosylated...
Background: Improvement of left ventricular function (also called reverse remodeling [LVRR]) is an important treatment goal in patients with dilated cardiomyopathy (DCM) and hypokinetic non-DCM (HNDC) prognostically favorable. We tested whether genetic DCM mutations impact LVRR independent from clinical parameters. Methods Results: Patients (n=346; mean ejection fraction, 30%) underwent genotyping for 47 DCM-associated genes addition to extensive phenotyping. was defined as improvement...
The thiazolidinedione (TZD) rosiglitazone is a peroxisome proliferator-activated receptor-gamma agonist that induces adipocyte differentiation and, hence, lipid accumulation. This in apparent contrast to the long-term glucose-lowering, insulin-sensitising effect of rosiglitazone. We tested whether action involves specific effects on mature adipocytes, which are different from those preadipocytes.Differentiated 3T3-L1 adipocytes were used as an vitro model. Transcriptomics, proteomics and...
Visfatin with the official gene name pre-B cell colony-enhancing factor 1 (PBEF) and protein nicotinamide phosphoribosyltransferase (NAMPT) is a recently discovered adipocyte-secreted that was shown by some to be associated visceral fat insulin resistance. To explore link between PBEF/NAMPT/visfatin lipid metabolism, we analyzed relation of its plasma level several parameters adiposity, resistance circulating blood profile in group general population (n = 40) subjects who are genetically...
Abstract Since organic acid analysis in urine with gaschromatography‐mass spectrometry (GC‐MS) is a time‐consuming technique, we developed new liquid chromatography‐quadrupole time‐of‐flight mass (LC‐QTOF/MS) method to replace the classical for diagnosis of inborn errors metabolism (IEM). Sample preparation simple and experimental time short. Targeted extraction automatic calculation z‐scores generated profiles characteristic IEMs our panel consisting 71 biomarkers defects amino acids,...
Recent studies have shown that dysfunction and decrease of regulatory T cells (Tregs) correlates with insulin resistance (IR), one the most significant mechanisms for type 2 diabetes mellitus (T2DM). To examine potential relationships among Tregs, IR, blood lipid content, related cytokines, we investigated frequency CD4+CD25+Foxp3+ as well expression levels interleukin 10 (IL-10) transforming growth factor-β (TGF-β) in newly diagnosed T2DM patients.Fifty-one patients 55 control individuals...
We have applied our recently designed proteomics apparoach to search for protein changes in the vivo adipocyte-enriched proteome from 8 overweight/obese subjects who underwent an intervention of 5 weeks a very low calorie diet followed by 3 normal diet. On average, persons lost 9.5 kg body weight largely contributed loss fat mass (7.1 kg). Various parameters adiposity and lipid metabolism changed significantly. Proteomics analysis revealed 6 significantly proteins. Analysis indicates that...