A5101521979- Distributed and Parallel Computing Systems
- Marine Biology and Ecology Research
- Weed Control and Herbicide Applications
- Pesticide and Herbicide Environmental Studies
- Parasite Biology and Host Interactions
- Crustacean biology and ecology
- Plant tissue culture and regeneration
- Parallel Computing and Optimization Techniques
- Advanced Data Storage Technologies
- Cloud Computing and Resource Management
- Allelopathy and phytotoxic interactions
- Scientific Computing and Data Management
- Cancer-related molecular mechanisms research
- Distributed systems and fault tolerance
- Plant Virus Research Studies
- Genomics and Phylogenetic Studies
- Peer-to-Peer Network Technologies
- MicroRNA in disease regulation
- Aquatic life and conservation
- Ichthyology and Marine Biology
- Marine Bivalve and Aquaculture Studies
- Service-Oriented Architecture and Web Services
- Fish Biology and Ecology Studies
- Chronic Kidney Disease and Diabetes
- Marine and coastal plant biology
Institute of Plant Protection
2020-2025
Chinese Academy of Agricultural Sciences
2020-2025
BioMarin (United States)
2024-2025
Shanghai Institute of Applied Physics
2023-2024
Chinese Academy of Sciences
2010-2024
Peking University
2021-2024
South China Sea Institute Of Oceanology
2021-2024
Institute of Oceanology
2007-2024
Institute of Food Science and Technology
2022-2024
Xiamen University
2023-2024
Abstract Primary ovarian insufficiency (POI) is a common cause of infertility in around 1–2% women aged <40 years. However, the mechanisms that POI are still poorly understood. Here we showed germ cell-specific knockout an essential autophagy induction gene Atg7 led to subfertility female mice. The deletion females was caused by severe follicle loss, which very similar human patients. Further investigation revealed resulted cell over-loss at neonatal transition period. In addition, our...
Sirt1 is a member of the sirtuin family proteins and has important roles in numerous biological processes. Sirt1-/- mice display an increased frequency abnormal spermatozoa, but mechanism spermiogenesis remains largely unknown. Here, we report that might be directly involved germ cells not steroidogenic cells. Germ cell-specific knockout were almost completely infertile; early mitotic meiotic progression spermatogenesis obviously affected after depletion, subsequent was disrupted by defect...
Complete and highly accurate reference genomes gene annotations are indispensable for basic biological research trait improvement of woody tree species. In this study, we integrated single-molecule sequencing high-throughput chromosome conformation capture techniques to produce a high-quality long-range contiguity chromosome-scale genome assembly the soft-seeded pomegranate cultivar 'Tunisia'. The covers 320.31 Mb (scaffold N50 = 39.96 Mb; contig 4.49 Mb) includes 33 594 protein-coding...
Objective Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, and its pathogenetic mechanism far from being understood. In this study, we aimed to explore the cellular molecular mechanisms that lead pathogenesis of disease. Methods We applied single-cell RNA sequencing (scRNA-seq) 57,288 peripheral blood mononuclear cells (PBMCs) five patients with pSS healthy controls. The immune cell subsets susceptibility genes involved in were analyzed. Flow cytometry was preformed verify...
The genome of the seadragon permits lifting veil on its mysterious looks and sex-determining locus.
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease that estimated to affect 35 million people worldwide and characterized by lymphocytic infiltration, elevated circulating autoantibodies, proinflammatory cytokines. The key immune cell subset changes the TCR/BCR repertoire alterations in pSS patients remain unclear. In this study, we sought comprehensively characterize transcriptional PBMCs of single-cell RNA sequencing V(D)J sequencing. Naive CD8+ T cells mucosal-associated...
Palmer amaranth (Amaranthus palmeri S. Watson), native to North America, is one of the most prominent invasive weed species on agricultural land. Acetolactate synthase (ALS)-resistant A. palmeri) widespread, while research focus resistance pattern and molecular basis imazethapyr seldom documented in China. An population that survived recommended rate was collected Shandong Province, The resistant mechanism investigated. Dose–response assay showed (R) displayed a high level (292.5-fold)...
<h3>Background:</h3> Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterised by accumulation of activated (myo)fibroblasts and excessive extracellular matrix deposition. The enhanced may be attributed, in part, to the process transforming growth factor β1 (TGFβ1)-induced epithelial–mesenchymal transition (EMT), phenotypic switching epithelial fibroblast-like cells. Although alveolar type II (ATII) cells have been shown undergo EMT, precise mediators mechanisms...
Abstract Sexually dimorphic (SD) traits are important in sexual selection and species survival, yet the molecular basis remains elusive, especially amphibians where SD have evolved repeatedly. We focus on Leishan moustache toad ( Leptobrachium leishanense ), which males develop nuptial spines their maxillary skin. Here we report a 3.5 Gb genome assembly with contig N50 of 1.93 Mb. find specific expansion intermediate filament gene family including numerous keratin genes. Within these genes,...
Like many important crops, peanut is a polyploid that underwent polyploidization, evolution, and domestication. The wild allotetraploid species Arachis monticola (A. monticola) an unique link from the diploid to cultivated tetraploid in lineage. However, little known about A. its role evolution domestication of this crop. A fully annotated sequence ≈2.6 Gb genome comparative genomics reported. Genomic reconstruction 17 diploids AA, BB, EE, KK, CC groups 30 tetraploids demonstrates...
The present study aimed to identify potential key genes and pathways in obese children order explore possible molecular mechanisms associated with child obesity. array dataset GSE29718 was downloaded from the Gene Expression Omnibus database. Subcutaneous adipose tissue samples derived 7 8 lean were selected for analysis. Differentially expressed (DEGs) compared those analyzed by limma package. ontology (GO) annotation, Kyoto Encyclopedia of Genes Genomes Reactome pathway enrichment analyses...
Accurate reference genomes have become indispensable tools for characterization of genetic and functional variations. Here we generated a high-quality assembly the melon Payzawat using combination short-read sequencing, single-molecule real-time Hi-C, high-density map. The final 12 chromosome-level scaffolds cover ∼94.13% estimated genome (398.57 Mb). Compared with published DHL92 genome, our exhibits 157-fold increase in contig length remarkable improvements centromeres telomeres. Six genes...
Beam shaping assembly (BSA) is a vital component in Boron Neutron Capture Therapy (BNCT) for obtaining epithermal neutron beams. Several feasible designs of BSA accelerator-based BNCT (AB-BNCT) source are carried out based on neutrons by bombarding natural lithium target with 10 mA, 2.8 MeV proton The calculation results demonstrate that thickness 45 cm appropriate general moderators referring to the therapeutic parameter Advanced Depth (AD). A series optimizations performed and two...
Excessive consumption of western diet (WD) induces obesity, resulting in cardiac dysfunction. Voluntary exercise ameliorates WD-induced but its effect on dysfunction remains unclear. Recent evidence suggests that elevated trimethylamine N-oxide (TMAO), a gut microbe-derived metabolite, can impair function obesity. We hypothesized obesity would be prevented by voluntary abolished TMAO supplementation. Male CD1 mice fed WD were assigned to sedentary, or with treatment for 8 weeks. normal (ND)...
Meiosis is a special type of cellular renovation that involves 2 successive cell divisions and single round DNA replication. Two major degradation systems, the autophagy-lysosome ubiquitin-proteasome, are involved in meiosis, but their roles have yet to be elucidated. Here we show autophagy mainly affects initiation meiosis not nuclear division. Autophagy works only by serving as dynamic recycling system also eliminating some negative meiotic regulators such Ego4 (Ynr034w-a). In quantitative...
The importance of allopolyploidy in plant evolution has been widely recognized. genetic changes triggered by allopolyploidy, however, are not yet fully understood due to inconsistent phenomena reported across diverse species. construction synthetic polyploids offers a controlled approach systematically reveal genomic that occur during the process polyploidy. This study reports first sequenced allopolyploid constructed from cross between Cucumis sativus and C. hystrix, with high-quality...