A5100412327- Air Quality and Health Impacts
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Climate Change and Health Impacts
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Reproductive biology and impacts on aquatic species
- Bioinformatics and Genomic Networks
- Global Health Care Issues
- Immune Cell Function and Interaction
- Biochemical effects in animals
- Aquaculture Nutrition and Growth
- Genomics and Phylogenetic Studies
- Hydrogen's biological and therapeutic effects
- Identification and Quantification in Food
- Traditional Chinese Medicine Studies
- Toxic Organic Pollutants Impact
- Per- and polyfluoroalkyl substances research
- Geochemistry and Geologic Mapping
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Environmental Toxicology and Ecotoxicology
- Atherosclerosis and Cardiovascular Diseases
Zhongnan Hospital of Wuhan University
2019-2025
Wuhan University
2019-2025
University of Bergen
2018-2025
First Affiliated Hospital of Gannan Medical University
2020-2025
Capital Medical University
2022-2025
Beijing Institute of Neurosurgery
2022-2025
Beijing Tian Tan Hospital
2022-2025
Hunan University
2024
West China Medical Center of Sichuan University
2024
Gannan Medical University
2021-2023
Background Human exposure to silica dust is very common in both working and living environments. However, the potential long-term health effects have not been well established across different situations. Methods Findings We studied 74,040 workers who worked at 29 metal mines pottery factories China for 1 y or more between January 1, 1960, December 31, 1974, with follow-up until 2003 (median of 33 y). estimated cumulative (CDE) each worker by linking work history a job–exposure matrix....
Introduction The pituitary and liver are among the main sites of action estrogens in fish. Years research has shown that xenoestrogens can interfere with functions estrogens. There is however incomplete understanding xenoestrogen targets genes, their molecular mechanisms potential effects some target organs, particularly pituitary. Methods We performed a comprehensive analysis transcriptome 72 h after injection ethynylestradiol (EE2: 10, 50 or 250 nmol/kg body weight/bw) bisphenol A (BPA: 8,...
A fully synthetic self-adjuvanting cancer vaccine candidate was constructed through covalent conjugation of invariant natural killer T (iNKT) cell ligand α-galactosylceramide (αGalCer) with sialyl Tn (STn), a representative tumor-associated carbohydrate antigen (TACA). This two-component STn-αGalCer is devoid antigenic peptide, featuring the well-defined structure high simplicity. showed remarkable efficacy in inducing antibody class switching from IgM to STn-specific IgG. Subtypes IgG were...
The aim of the present study was to investigate effects defined mixtures polycyclic aromatic hydrocarbons (PAHs) and perfluoroalkyl substances (PFASs), at low, environmentally relevant (1× = L), or high (20× H) doses, on biological responses in Atlantic cod (Gadus morhua). To this end, farmed juvenile were exposed day 0 7 via intraperitoneal (i.p.) injections, a two-week vivo experiment. In total, there 10 groups fish (n 21-22): two control groups, four separate exposure PAH PFAS (L, H),...
Abstract Background With the cost of DNA sequencing decreasing, increasing amounts RNA-Seq data are being generated giving novel insight into gene expression and regulation. Prior to analysis expression, has be processed through a number steps resulting in quantification each gene/transcript analyzed samples. A workflows available help researchers perform these on their own data, or public take advantage software reference re-analysis. However, many existing limited specific types studies....
The aim of the present study was to investigate effects per- and polyfluoroalkyl substances (PFAS), both single compounds a mixture these, using precision-cut liver slices (PCLS) from Atlantic cod (Gadus morhua). PCLS were exposed for 48 h perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA) perfluorononanoate (PFNA) (10, 50 100 μM), three mixtures these at equimolar concentrations μM). Transcriptomic responses assessed RNA sequencing. Among exposures PFAS, PFOS produced highest...
Relapsed/refractory (r/r) primary central nervous system lymphoma (PCNSL) is an intractable situation without sound treatment. Bruton's tyrosine kinase (BTK) represents attractive drug target in PCNSL. Orelabrutinib a new-generation BTK inhibitor with high cerebrospinal fluid (CSF) concentration. This study aimed to evaluate the efficacy and safety of orelabrutinib-containing combination therapy patients r/r PCNSL.We retrospectively analyzed PCNSL who received rituximab, high-dose...
How an organism copes with chemicals is largely determined by the genes and proteins that collectively function to defend against, detoxify eliminate chemical stressors. This integrative network includes receptors transcription factors, biotransformation enzymes, transporters, antioxidants, metal- heat-responsive genes, known as defensome. Teleost fish largest group of vertebrate species can provide valuable insights into evolution functional diversity defensome genes. We have previously...
Abstract Background Recent studies have suggested that folic acid can restore abnormal DNA methylation and monocyte subset shifts caused by hyperhomocysteinemia (HHcy) hyperlipidemia (HL). However, the exact mechanism of action is still not fully understood. In this study, we further investigated reversal effect underlying on shift in subsets induced aberrant lipids Hcy metabolism via vitro vivo. Results Our results showed intermediate monocytes were significantly increased but had lowest...
Abstract Esophageal squamous cell carcinoma (ESCC) is characterized by high morbidity and mortality. Circular RNAs (circRNAs) play an important role in tumor progression. We discovered aberrantly expressed circRNA (hsa_circ_0021727) patients with ESCC. However, the mechanism of action hsa_circ_0021727 tumors unclear. The present study aimed to investigate biological its ESCC screened for expression patients. Patients had shorter survival than those low expression. Hsa_circ_0021727 promoted...
Ambient carbon monoxide (CO) exposure is associated with increased mortality and hospitalization risk for total respiratory diseases. However, evidence on the of specific diseases from ambient CO limited.Data daily hospitalizations diseases, air pollutants, meteorological factors January 2016 to December 2020 were collected in Ganzhou, China. A generalized additive model quasi-Poisson link lag structures was used estimate associations between concentration asthma, chronic obstructive...
Abstract Background DNA methylation-regulated genes have been demonstrated as the crucial participants in occurrence of coronary heart disease (CHD). The machine learning based on has tremendous potential for mining non-invasive predictive biomarkers and exploring underlying new mechanisms CHD. Results First, 2085 age-gender-matched individuals Framingham Heart Study (FHS) were randomly divided into training set validation set. We then integrated methylome transcriptome data peripheral blood...
Objective Previous epidemiological studies have shown that both long-term and short-term exposure to fine particulate matters (PM 2.5 ) were associated with the morbidity mortality of circulatory system diseases (CSD). However, impact PM on CSD remains inconclusive. This study aimed investigate associations between in Ganzhou. Methods We conducted this time series explore association ambient daily hospital admissions for from 2016 2020 Ganzhou by using generalized additive models (GAMs)....
Claudin 18.2 (CLDN18.2)-targeting chimeric antigen receptor (CAR)-modified T cells are one of the few cell therapies currently producing an impressive therapeutic effect in treating solid tumors; however, their long-term efficacy is not satisfactory with a short duration response. Transgenic expression interleukin (IL)-15 has been reported to promote T-cell expansion, survival, and function enhance antitumor activity engineered vitro vivo . Therefore, this study aimed explore whether IL-15...