A5102764623- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Natural product bioactivities and synthesis
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Sperm and Testicular Function
- CAR-T cell therapy research
- interferon and immune responses
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Pharmacological Effects of Natural Compounds
- Immune Response and Inflammation
- Kruppel-like factors research
- Ginseng Biological Effects and Applications
- Cytokine Signaling Pathways and Interactions
- Nerve injury and regeneration
- Erythrocyte Function and Pathophysiology
- Total Knee Arthroplasty Outcomes
- Anesthesia and Pain Management
- Quinazolinone synthesis and applications
- Inflammatory Biomarkers in Disease Prognosis
- Immunotherapy and Immune Responses
Second Affiliated Hospital of Jilin University
2016-2025
West China Medical Center of Sichuan University
2025
Shandong University
2025
Union Hospital
2024
Jilin University
2012-2024
Analytical Biosciences (China)
2024
Qingdao University
2021-2024
Affiliated Hospital of Hangzhou Normal University
2024
Affiliated Hospital of Hebei University
2023-2024
Nanchang University
2018-2024
Abstract Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at the clinical level. We identify TRAF2- and NCK-interacting kinase (TNIK) as anti-fibrotic target using predictive artificial intelligence (AI) approach. Using AI-driven methodology, we generated INS018_055, small-molecule TNIK inhibitor, which exhibits desirable drug-like properties activity...
Increasing studies have shown that specific mRNAs and miRNAs expressed in mature sperm may be related to motility. However, the expression profiles roles of lncRNAs remain unknown. In present study, numerous were identified human sperm, some exclusively testis. Compared with those normal lncRNA asthenozoospermia (AZS) showed significant differences. Gene ontology pathway analyses function differentially targets between AZS closely linked many processes involved spermatogenesis function....
Abstract STUDY QUESTION What is the significance and mechanism of human seminal plasma extracellular vesicles (EVs) in regulating sperm functions? SUMMARY ANSWER EV increases intracellular Ca2+ concentrations [Ca2+]i via influx by activating CatSper channels, subsequently modulate motility, especially hyperactivated which attributed to both protein non-protein components EV. WHAT IS KNOWN ALREADY EVs are functional regulators function, cargoes from normal asthenozoospermic different....
Abstract We developed a simple and meaningful preparative method for the separation purification of main phenolic compounds from leaves celery ( Apium graveolens L. var. dulce Mill./Pers.) we established an accurate specific analytical identification leaves. The crude extract was prefractioned by polyamide resin to enrich compounds. They were then purified further high‐performance liquid chromatography, seven obtained: including chlorogenic acid, luteolin 7‐ O ‐β ‐d‐ apiofuranosyl(1→2)‐β...
Abstract Glioma, the most predominant primary malignant brain tumor, remains uncured due to absence of effective treatments. Hence, it is imperative develop successful therapeutic agents. This study aimed explore antitumor effects and mechanisms ivermectin (IVM) in glioma cells vitro vivo. The IVM on cell viability, cycle arrest, apoptosis rate, morphological characteristics were determined respectively by MTT assay/colony formation assay, flow cytometry, transmission electron microscope. In...
Claudin 18.2 (CLDN18.2)-targeting chimeric antigen receptor (CAR)-modified T cells are one of the few cell therapies currently producing an impressive therapeutic effect in treating solid tumors; however, their long-term efficacy is not satisfactory with a short duration response. Transgenic expression interleukin (IL)-15 has been reported to promote T-cell expansion, survival, and function enhance antitumor activity engineered vitro vivo . Therefore, this study aimed explore whether IL-15...
Abstract T-Cell-derived extracellular vesicles (TcEVs) play key roles in immune regulation and tumor microenvironment modulation. However, the heterogeneity of TcEV remains poorly understood due to technical limitations EV analysis lack comprehensive data. To address this, we constructed TcEVdb, a database that explores expression cluster by SEVtras method from T-cell single-cell RNA sequencing TcEVdb contains 277 265 droplets 51 types across 221 samples 21 projects, covering 9 tissue...
Abstract Ferroptosis is a newly identified cell death triggered by iron‐induced lipid peroxidation. Numerous studies reveal that ferroptosis participates in multiple types of tissue injury including ischaemia–reperfusion (I/R) and doxorubicin (Dox)‐induced damage. Targeting promising approach for disease treatment as the blockade efficiently alleviates symptoms. However, no known inhibitors have been used clinical treatment. Although certain compounds act vitro, whether these drugs cure...
Chilling stress affects plant growth and productivity. However, the multi-underlying mechanisms of chilling tolerance are not well understood. Arabidopsis PCaP2 is involved in regulating dynamic microtubules (MTs) F-actin Ca2+-binding ability. Here, results showed that expression was highly induced roots, cotyledons, true leaves, lateral roots flowers under cold stress. Compared with wild type, PCaP2-overexpressing plants displayed enhanced tolerance, whereas its RNAi mutant were more...
The two estrogen receptors ERα and ERβ are nuclear that bind (E2) function as ligand-inducible transcription factors. They homologues can form dimers with each other to the same estrogen-response element motifs in DNA. drives breast cancer growth whereas has been reported be anti-proliferative. However, they rarely expressed cells, it is not fully investigated which extent their functions different because of inherent differences or cellular context. To dissect similarities differences, we...
Abstract PKM2 is an important regulator of the aerobic glycolysis that plays a vital role in cancer cell metabolic reprogramming. In general, Trib2 considered as “pseudokinase”, contributing to different kinds cancer. However, detailed roles TRIB2 regulating metabolism by remain unclear. This study demonstrated TRIB2, not has kinase activity directly phosphorylate at serine 37 cells. The elevated pSer37-PKM2 would subsequently promote dimers enter into nucleus and increase expression LDHA,...
Objective: Umbilical cord-derived mesenchymal stem cell membrane-loaded minoxidil (MXD) nanoparticles (STCM-MXD-NPs) were prepared to investigate their effects on hair growth in C57BL/6J mice. Methods: STCM-MXD-NPs obtained by freeze-thawing and differential centrifugation, evaluated using The mRNA protein expression levels of vascular endothelial factor (VEGF) insulin-like factor-1 (IGF-1) detected real-time polymerase chain reaction enzyme-linked immunosorbent assays, respectively. Protein...
Abstract Background Chimeric antigen receptor CAR-T cell therapies have ushered in a new era of treatment for specific blood cancers, offering unparalleled efficacy cases resistance or relapse. However, the emergence cytokine release syndrome (CRS) as side effect poses challenge to widespread application therapies. Melatonin, natural hormone produced by pineal gland known its antioxidant and anti-inflammatory properties, has been explored potential immunomodulatory effects. Despite this,...
Background: Trapa bispinosa shells (TBs) and its flesh (TBf) have been recognized for their medicinal properties, including antioxidant, antitumor, immunomodulatory effects. Despite these benefits, TBs are often discarded as waste material, applications remain to be further explored. Methods: In this study, we optimized the solid-state fermentation process of Ganoderma sinense (GS) with using a response surface experiment methodology obtain fermented production highest water extract rate...