A5100326877- Chemical synthesis and alkaloids
- Synthesis and biological activity
- Carbohydrate Chemistry and Synthesis
- Synthesis of Indole Derivatives
- Quinazolinone synthesis and applications
- Asymmetric Synthesis and Catalysis
- Synthesis and Biological Evaluation
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects of Natural Compounds
- Catalytic C–H Functionalization Methods
- Bioactive Compounds and Antitumor Agents
- Ginger and Zingiberaceae research
- Synthesis and Characterization of Heterocyclic Compounds
- Pneumocystis jirovecii pneumonia detection and treatment
- Synthetic Organic Chemistry Methods
- Organic Electronics and Photovoltaics
- Catalytic Alkyne Reactions
- HIV/AIDS drug development and treatment
- Polyamine Metabolism and Applications
- Synthesis of Organic Compounds
- Luminescence and Fluorescent Materials
- Alkaloids: synthesis and pharmacology
- Synthesis and Properties of Aromatic Compounds
- Advanced Synthetic Organic Chemistry
- Medicinal Plant Pharmacodynamics Research
Nanjing University of Chinese Medicine
2017-2025
Shenyang Pharmaceutical University
2008-2025
Yangzhou University
2024
China Pharmaceutical University
2011-2023
Chinese Academy of Sciences
2023
Beijing National Laboratory for Molecular Sciences
2023
Institute of Chemistry
2023
Yichun University
2023
Shanghai Institute of Organic Chemistry
2022
University of Chinese Academy of Sciences
2022
Non-benzenoid acenes containing heptagons have received increasing attention. We herein report a heptacene analogue quinoidal benzodi[7]annulene core. Derivatives of this new non-benzenoid acene were obtained through an efficient synthetic strategy involving Aldol condensation and Diels-Alder reaction as key steps. The configuration can be modulated from wavy to curved one by just varying the substituents (triisopropylsilyl)ethynyl group 2,4,6-triisopropylphenyl (Trip) group. When mesityl...
A cost-effective, highly regioselective and metal-free version for the synthesis of indolizine derivatives by means Tf2O-mediated cascade reaction pyridyl-enaminones thiophenols/thioalcohols under mild conditions has been reported. Diverse electron-rich could be obtained in up to 94% yield via selective 1,4-addition vinyl iminium triflate tandem cyclization/aromatization, which allowed simultaneous construction C–N C–S/and one example C–Se bonds.
We report the first attempt of double-spot structural modification on a side-chain moiety sulfonium-type α-glucosidase inhibitors isolated from genus Salacia. A series sulfonium salts with benzylidene acetal linkage at C3′ and C5′ positions were designed synthesized. In vitro enzyme inhibition evaluation showed that compounds strong electron-withdrawing group attached ortho position phenyl ring present stronger inhibitory activities. Notably, most potent inhibitor 21b (1.0 mpk) can exhibit...
In order to improve the antitumor potency of natural product evodiamine, novel boron-containing evodiamine derivatives were designed by incorporating boronic acid and boronate as trigger units. Boronate derivative 13a could be triggered reactive oxygen species (ROS) in HCT116 colon cancer cell line showed excellent activity vitro vivo. It induced apoptosis cells a dose-dependent manner growth arrest at G2 phase.
Abstract There are health benefits from consuming cruciferous vegetables that release indole-3-carbinol (I3C), but the in vivo transformation of I3C-related indoles remains underinvestigated. Here we detail post-ingestion conversion I3C into antitumor agents, 2-(indol-3-ylmethyl)-3,3′-diindolylmethane (LTr1) and 3,3′-diindolylmethane (DIM), by conceptualizing materializing reaction flux derailing (RFD) approach as a means unraveling these stepwise transformations to be non-enzymatic...
Hypoxia is a state of low oxygen tension that found in numerous solid tumors. Generally, nitroreductase (NTR) overexpressed and directly correlated with the hypoxic status tumors, supporting hypothesis prodrug could be activated by intracellular NTR lead to potential antitumor therapy. Herein, evodiamine-based hypoxia-targeting theranostic agents were developed enhance efficacy. These are NTR-mediated p-nitrobenzyl reduction, enabling simultaneous fluorophore activation for imaging...
This work presents enzymatic synthesis of four health-beneficial oligoindoles (DIM, LTr1, LTe2, and LTr3) using peroxidase. Green chemistry metrics EcoScale score evaluations supported this method as a green protocol.
A computational study on the experimentally detected Sc3N@C68 cluster is reported, involving quantum chemical analysis at B3LYP/6-31G* level. Extensive computations were carried out pure C68 cage which does not conform with isolated pentagon rule (IPR). The two maximally stable isomers selected as initial structures. Full geometry optimization leads to a confirmation of an earlier assessment equilibrium (Nature 2000, 408, 427), namely eclipsed arrangement Sc3N in 6140 frame, where each Sc...
Abstract Herein, we disclose the N‐heterocyclic carbene (NHC)‐catalyzed [3+3] annulation of challenging esters with methyl ketoimines for highly enantioselective synthesis intriguing δ‐lactams featuring various substituent patterns. The occurs under mild conditions and offers good tolerance, yields excellent enantioselectivities. six‐membered heterocyclic products are valuable bioactive molecules. magnified image
The first organocatalytic hetero-Diels–Alder reaction of an <italic>in situ</italic> generated diene with α-keto esters was reported for the construction chiral dihydropyranones.
A novel synthetic approach to construct various 3,6-anhydrohexosides via an intramolecular cyclization of corresponding triflates is described. The nucleophilic attack from C3 p-methoxybenzylated hydroxyl C6 trifluoromethanesulfonate on triflate structures triggered the reaction provide in excellent yields, making strategy more efficient with respect reported protocols. By applying this methodology, a concise first total synthesis natural product isolated leaves Sauropus rostratus was accomplished.
We report a synthetic methodology for the construction of fused heterocyclic compounds pyrido[2,1- b ]quinazolin-9(1 H )-ones and pyrrolo[2,1- through an AgOTf-catalyzed intramolecular alkyne hydroamination reaction. The is applicable to wide scope substrates produces series quinazolinone heterocycles in good excellent yields.
Duck tembusu virus (DTMUV) was firstly identified in 2010 China; since then, it has caused enormous economic loss to breeding industry. Great efforts have been made develop drugs and vaccines against DTMUV. However, current available or anti-DTMUV are consistently inefficient. Hence, various more broadly effective become important for the treatment of DTMUV infection; among these, lycorine, one sources active alkaloids, is a promising example. Nevertheless, not known whether lycorine any...
CTr (5,6,11,12,17,18-hexahydrocyclononal[1,2-b:4,5-b′:7,8-b″]triindole) is a unique 9-membered indole-fused cycloalkane alkaloid with improved druglike privilege and therapeutic potential, but its supply issue remains unsolved, which thus restrains further exploration. Here, using [EMIm][HSO4] as catalyst solvent, we present an efficient synthesis of from 3-[(phenylmethoxy)methyl]-1H-indole (O-Bn-I3C) readily prepared indole-3-carbinol (I3C). The multiple H-bonding interactions O-Bn-I3C were...
Cruciferous vegetables (CVs) are globally consumed with some health benefits believed to arise from indole-3-carbinol (I3C), a labile phytochemical liberated indole glucosinolates, but few reports describe the effect of cooking on I3C reactions. Here, we present heat-promoted direct conversions in broccoli florets into derivatives, which unique N-indolylmethylation and -hydroxymethylation nuclei by 3-methyleneindole formaldehyde formed situ dehydration dimerization 3,3′-diindolylmethane...