A5100420834- Retinal Diseases and Treatments
- X-ray Diffraction in Crystallography
- Wound Healing and Treatments
- Extracellular vesicles in disease
- Crystallization and Solubility Studies
- Nerve injury and regeneration
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Catalytic C–H Functionalization Methods
- Mesenchymal stem cell research
- Advanced Synthetic Organic Chemistry
- MicroRNA in disease regulation
- Systemic Lupus Erythematosus Research
- Phytochemistry and Biological Activities
- Neurogenesis and neuroplasticity mechanisms
- Galectins and Cancer Biology
- Chemical Synthesis and Analysis
- Acne and Rosacea Treatments and Effects
- PI3K/AKT/mTOR signaling in cancer
- Tuberculosis Research and Epidemiology
- Liver physiology and pathology
- Antibiotics Pharmacokinetics and Efficacy
- Cancer-related Molecular Pathways
- Ocular Diseases and Behçet’s Syndrome
- Wnt/β-catenin signaling in development and cancer
Yichun University
2020-2025
Sansure Biotech (China)
2024-2025
University of Southern California
2018-2025
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Zhejiang Provincial People's Hospital
2024
Zhejiang Chinese Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Peking Union Medical College Hospital
2017-2024
Renmin Hospital of Wuhan University
2018-2024
Abstract We tested the hypothesis that 1,25‐dihydroxyvitamin D 3 [1α,25(OH) 2 ] has antiaging effects via upregulating nuclear factor (erythroid‐derived 2)‐like (Nrf2), reducing reactive oxygen species (ROS), decreasing DNA damage, p16/Rb and p53/p21 signaling, increasing cell proliferation, cellular senescence senescence‐associated secretory phenotype (SASP). demonstrated 1,25(OH) ‐deficient [1α(OH)ase −/− mice survived on average for only months. Increased tissue oxidative stress...
Abstract Extracellular vesicles (EV) containing microRNAs (miRNAs) have tremendous potential as biomarkers for the early detection of disease. Here, we present a simple and rapid PCR-free integrated microfluidics platform capable absolute quantification (<10% uncertainty) both free-floating miRNAs EV-miRNAs in plasma with 1 pM sensitivity. The assay time is only 30 minutes opposed to 13 h requires ~20 μL sample oppose mL conventional RT-qPCR techniques. integrates surface acoustic wave...
Angiogenesis plays a critical role in diabetic wound healing. However, no effective strategies have been developed to target endothelial cells (ECs) facilitate Dapagliflozin (DA) as sodium-glucose linked transporter 2 (SGLT2) inhibitor, may promote neovascularization mice via HIF-1α-mediated enhancement of angiogenesis. Here, the bioinspired nanovesicles (NVs) prepared from induced pluripotent stem cells-derived ECs through an extrusion approach are reported, which can function exosome...
Abstract Background Serotonin (5‐hydroxytryptamine) is a multifunctional bioamine serving as neurotransmitter, peripheral hormone and mitogen in the vertebrate system. It has pleiotropic activities central nervous system gastrointestinal function via an orchestrated action of serotonergic elements, particularly serotonin receptor‐mediated signalling cascades. The mitogenic properties have garnered recognition for years been exploited repurposing serotonergic‐targeted drugs cancer therapy....
A novel and efficient method for the synthesis of multisubstituted arylnitriles via Tf2O-mediated [3 + 2 1] benzannulation enaminones acylacetonitriles has been developed. This reaction proceeds under mild conditions with excellent functional group compatibility. Mechanistic studies have revealed that cyclization involves two consecutive nucleophilic additions, followed by a cascade Knoevenagel condensation aromatization. Additionally, trifluoromethanesulfonate 6 identified as crucial...
Inflammation is one of the crucial mechanisms mediating spinal cord injury (SCI) progress. Sesamol, a component sesame oil, has anti-inflammatory activity, but its mechanism in SCI remains unclear. We investigated if AMPK/SIRT1/NF-κB pathway participated anti-inflammation sesamol SCI. Sesamol could inhibit neuronal apoptosis, reduce neuroinflammation, enhance M2 phenotype microglial polarization, and improved motor function recovery mice after Furthermore, increased SIRT1 protein expression...
Abstract Background It is documented that mesenchymal stem cells (MSCs) secrete extracellular vesicles (EVs) to modulate subarachnoid hemorrhage (SAH) development. miR-140-5p expression has been detected in MSC-derived EVs, while the mechanism of EVs containing SAH remains unknown. We aim fill this void by establishing mouse models and extracting MSCs MSC-EVs. Methods After ALK5 was silenced mice, neurological function evaluated, neuron apoptosis TdT-mediated dUTP-biotin nick end labeling...
A cost-effective, highly regioselective and metal-free version for the synthesis of indolizine derivatives by means Tf2O-mediated cascade reaction pyridyl-enaminones thiophenols/thioalcohols under mild conditions has been reported. Diverse electron-rich could be obtained in up to 94% yield via selective 1,4-addition vinyl iminium triflate tandem cyclization/aromatization, which allowed simultaneous construction C–N C–S/and one example C–Se bonds.
Abstract Background To evaluate changes of microvascular network macular and peripapillary regions to provide a quantitative measurement foveal avascular zone (FAZ) in unilateral BRVO patients. Methods Forty-seven patients forty-seven normal controls were enrolled. A 3*3 mm scan centered on fovea followed by 4.5*4.5 optic nerve head (ONH) obtained eyes, fellow eyes control each individual using OCTA (Optovue Inc., Fremont, CA, USA). Vessel density (VD) superficial (SVC) deep vascular complex...
Isoniazid (INH) is a crucial first-line anti tuberculosis (TB) drug used in adults and children. However, various factors can alter its pharmacokinetics (PK). This article aims to establish population pharmacokinetic (popPK) models repository of INH facilitate clinical use.
Isoniazid exposure in vivo is significantly affected by NAT2 genotypes and has ethnic differences. To optimize the sampling strategy for isoniazid East Asian pediatric populations. We employed a model-informed optimization approach based on INH population pharmacokinetic (PopPK) models. selected PopPK models children adults optimized using PopED (Population Experimental Design), method that helps identify most efficient points maximizing parameter estimation accuracy. Virtual patients with...
The effect of Polygonum multiflorum against hair loss has been widely recognized. 2,3,5,4′-Tetrahydroxystilbene-2-O-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>-D-glucoside (TSG) is the main component ; however, its role in regeneration not established. To evaluate growth-promoting activity TSG, depilated C57BL/6J mice were topically treated with normal saline, Pifithrin-<mml:math...
We investigated the relationship between significantly different genes of mitochondria-to-nucleus retrograde signaling pathway (RTG) in H1299 ρ0 cells (mtDNA depleted cell) and compared their radiosensitivity to that parental ρ cells, determine possible intervention targets radiosensitization. were mitochondrial DNA by chronic culturing ethidium bromide at low concentration. Radiosensitivity was analyzed using clonogenic assay. Western blot used analyze cell cycle-related proteins,...
Protein phosphatase 2A (PP2A), a family of the major serine/threonine phosphatases in cells, regulates many aspects physiological processes. However, isoform-specific substrates and biological role each specific member PP2A remain largely unknown. In this study, we investigated whether catalytic subunit C α (PP2Ac ) is involved chronic hepatic injury fibrosis. A hepatocyte-specific PP2Ac ablation mice model was established to examine effect on carbon tetrachloride- (CCl4-) induced Our...
Abstract Schwann cells (SCs) can promote the regeneration of injured peripheral nerves while clinical application is limited by donor site complications and inability to generate an ample amount cells. In this study, we have isolated human eyelid adipose-derived (hE-SCs) from adipose tissue identified cell phenotype function. Using immunofluorescence H & E staining, detected subtle nerve fibers SCs in tissue. Immunofluorescence staining indicated that hE-SCs expressed glial markers, such...
Purpose To assess the retinal vasculature changes quantitatively using wide-field optical coherence tomography angiography (OCTA) in systemic lupus erythematosus (SLE), and explore its correlation with clinical features. Design Prospective, cross-sectional, observational study. Participants controls Patients SLE who presented to Ophthalmology Department of Peking Union Medical College Hospital from November 2022 April 2023 were collected. The subjects divided into retinopathy without groups....
A variety of enynals and dihydrobenzo[
AIM: To determine acute and chronic choroidal vascular changes after vortex vein occlusion in monkeys. METHODS: One or two temporal veins were occluded 8 cynomolgus Fluorescein angiography (FA), indocyanine green angiogram (ICGA), enhanced-depth imaging optical coherence tomography (EDI-OCT) performed preoperatively at 1d, 1, 4, 12wk occlusion. EDI-OCT images binarized to calculate the choroid index (CVI). RESULTS: ICGA showed delayed filling of arteries quadrants eyes with within 1wk. The...
Abstract Monocyte chemotactic protein-1-induced protein 1 (MCPIP1) plays a important role in ischemia/reperfusion (I/R) injury. Autophagy is involved activating endothelial cells response to I/R. However, researchers have not clearly determined whether MCPIP1 mediates I/R injury via autophagy, and its downstream mechanism remains unclear. Western blotting analyses immunocytochemistry were applied detect levels detected HUVECs. An vitro scratch assay was used cell migration. Cells transfected...
Almost half of the patients exhibit futile recanalization after thrombectomy; however, early postoperative predictors remain unclear. We analyzed relationship post-thrombectomy ASPECTS (Post-ASPECTS) with 90-day prognosis and hemorrhagic transformation (HT).We collected data from acute ischemic stroke (AIS) anterior-circulation large vessel occlusion (ACLVO) who were treated via thrombectomy within 10 h in 3 hospitals. Successful endovascular was achieved (modified thrombolysis cerebral...
Abstract An efficient CAN‐mediated C−C bond formation in the oxidative reactions of xanthenes with enaminones under mild reaction conditions are described. A variety 9H‐xanthene‐9‐ylidene aldehydes could be synthesized up to 90% yield via one‐pot manner good functional group compatibility, which achieved simultaneous construction carbon‐carbon double and carbon‐oxygen bond.