A5100718896- HIV Research and Treatment
- Immune Cell Function and Interaction
- HIV/AIDS drug development and treatment
- CAR-T cell therapy research
- Stroke Rehabilitation and Recovery
- Transcranial Magnetic Stimulation Studies
- COVID-19 Clinical Research Studies
- Muscle activation and electromyography studies
- Epigenetics and DNA Methylation
- Spinal Cord Injury Research
- interferon and immune responses
- HIV/AIDS Research and Interventions
- Immune Response and Inflammation
- Multiple Myeloma Research and Treatments
- Acupuncture Treatment Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunotherapy and Immune Responses
- Stochastic processes and statistical mechanics
- Trace Elements in Health
- Mast cells and histamine
- Balance, Gait, and Falls Prevention
- Pneumonia and Respiratory Infections
- Tuberculosis Research and Epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV-related health complications and treatments
Sun Yat-sen University
2017-2025
Anhui Medical University
2024-2025
Anhui Mental Health Center
2025
Cleveland Clinic
2025
Tianjin University of Science and Technology
2025
China Medical University
2025
Union Hospital
2022-2024
Huazhong University of Science and Technology
2018-2024
Zhejiang University-University of Edinburgh Institute
2023-2024
University of Science and Technology of China
2024
Background and Aim: Increasing evidence suggests that spinal cord injury (SCI)-induced defects in autophagic flux may contribute to an impaired ability for neurological repair following injury. Transcription factor E3 (TFE3) plays a crucial role oxidative metabolism, lysosomal homeostasis, autophagy induction. Here, we investigated the of TFE3 modulating SCI explored its impact on recovery. Methods: Histological analysis via HE, Nissl Mason staining, survival rate analysis, behavioral...
Abstract The inhibitory receptors PD-1, Tim-3, and Lag-3 are highly expressed on tumor-infiltrating lymphocytes compromise their antitumor activity. For efficient cancer immunotherapy, it is important to prevent chimeric antigen receptor T (CAR-T)-cell exhaustion. Here we downregulate these three checkpoint simultaneously CAR-T cells that show the resulting PTL-CAR-T undergo epigenetic modifications better control tumor growth. Furthermore, unexpectedly find increased infiltration by...
Comprehensively elucidating the molecular mechanisms of human immunodeficiency virus type 1 (HIV-1) latency is a priority to achieve functional cure. As current 'shock' agents failed efficiently reactivate latent reservoir, it important discover new targets for developing more efficient latency-reversing (LRAs). Here, we found that TRIM28 potently suppresses HIV-1 expression by utilizing both SUMO E3 ligase activity and epigenetic adaptor function. Through global site-specific SUMO-MS study...
BACKGROUND. Chimeric antigen receptor (CAR) T cells have emerged as an approach to treat malignant tumors. This strategy has also been proposed for the treatment of HIV-1 infection. We developed a broadly neutralizing antibody–derived (bNAb-derived) CAR cell therapy that can exert specific cytotoxic activity against HIV-1–infected cells.
Spinal cord injury (SCI), a fatal disease in the central nervous system, is characteristic of weak neuronal regeneration ability and complex pathological progress. Activation oxidative stress (OS) apoptosis-mediated cell death significantly contributes to progression SCI. Current evidence suggests that maltol exerts natural antioxidative properties via obstructing OS apoptosis. However, significant effect on SCI treatment has never been evaluated yet. In our current study, we explored...
As a debilitating condition that can impact whole spectrum of people and involve multi-organ systems, long COVID has aroused the most attention than ever. However, mechanisms are not clearly understood, underlying biomarkers affect long-term consequences COVID-19 paramount to be identified.
Abstract Non‐antibiotic strategies are desperately needed to treat post‐traumatic osteomyelitis (PTO) due the emergence of superbugs, complex inflammatory microenvironments, and greatly enriched biofilms. Previously, growing evidence indicated that quorum sensing (QS), a chemical communication signal among bacterial cells, can accelerate resistance under evolutionary pressure. This study aims develop medical dressing PTO by inhibiting QS regulating microenvironment, which includes severe...
Here, we present the first case-study where microdialysis is used to investigate pharmacokinetics of antibody in different regions rat brain. Endogenous IgG was understand disposition at steady-state and exogenously administered trastuzumab a dynamic setting. Microdialysis samples from striatum (ST), lateral ventricle (LV), cisterna magna (CM) were collected, along with plasma brain homogenate, comprehensively antibodies. Antibody concentrations cerebrospinal fluid (CSF) found vary based on...
Inflammation is one of the crucial mechanisms mediating spinal cord injury (SCI) progress. Sesamol, a component sesame oil, has anti-inflammatory activity, but its mechanism in SCI remains unclear. We investigated if AMPK/SIRT1/NF-κB pathway participated anti-inflammation sesamol SCI. Sesamol could inhibit neuronal apoptosis, reduce neuroinflammation, enhance M2 phenotype microglial polarization, and improved motor function recovery mice after Furthermore, increased SIRT1 protein expression...
Background . The efficacy of robotic‐assisted gait training (RAGT) should be considered versatilely; among which, assessment is one the most important measures; observational commonly used method in clinical practice, but it has certain limitations due to deviation subjectivity; instrumental assessments such as three‐dimensional analysis (3DGA) and surface electromyography (sEMG) can obtain data muscle activation during walking stroke patients with hemiplegia, so better evaluate...
Receptor-mediated transcytosis (RMT) is used to enhance the delivery of monoclonal antibodies (mAb) into central nervous system (CNS). While binding endogenous receptors on brain capillary endothelial cells (BCECs) may facilitate uptake mAbs in brain, a strong affinity for receptor hinder efficiency transcytosis. To quantitatively investigate effect pharmacokinetics (PK) anti-transferrin (TfR) different regions rat we conducted microdialysis study directly measure concentration free at sites...
T cell lymphoma (TCL) is a highly heterogeneous group of diseases with poor prognosis and low 5-year overall survival rate. The current therapeutic regimens have relatively efficacy rates. Clinical studies single-target chimeric antigen receptor (CAR-T cell) therapy in lymphocytes require large multiple infusions, increasing the risks cost treatment; therefore, optimizing targeted way to improve prognosis. Despite significant advances bispecific CAR-T avoid escape treatment B lymphoma,...
Abstract The CD4+CD25+FOXP3+ regulatory T cells (Tregs) mediate immunological self-tolerance and suppress various immune responses. FOXP3 is a key transcriptional factor for the generation development of Tregs. Its expression regulated by cytokines including TGF-β, IL-2, IL-10. It important to further identify factors Given that many microRNAs (miRNAs) could specifically interact with core promoter region enhance transcription target genes, we searched any possible miRNA(s) targeting gene....
ABSTRACT HIV‐1 establishes a stable latent reservoir in host cells such as CD4 + T lymphocytes, which cannot be recognized by the immune system. Accurately assessing active RNA is crucial for clinical diagnoses and treatment. Reverse transcription (RT)‐polymerase chain reaction (PCR)‐based assays are commonly employed to detect reservoirs settings, but single‐site probe designs limit their ability distinguish between intact defective proviral transcripts. In this study, we present optimize...
Abstract Platinum compounds remain the backbone of chemotherapy regimens for a variety solid tumors, despite their well-described adverse effects nephrotoxicity, ototoxicity, and neurotoxicity. Cisplatin ototoxicity results from damage to cochlear outer hair cells remains key dose-limiting toxicity in pediatric cancers, where its incidence reaches as high 90% testicular cancer patients. However, mechanistic underpinnings cisplatin incompletely understood no treatments exist prevent onset....