A5034519027- Advanced Drug Delivery Systems
- Metaheuristic Optimization Algorithms Research
- Lipid Membrane Structure and Behavior
- Evolutionary Algorithms and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Advancements in Transdermal Drug Delivery
- Obsessive-Compulsive Spectrum Disorders
- Advanced Multi-Objective Optimization Algorithms
- Antibiotic Resistance in Bacteria
- Schizophrenia research and treatment
- Polymer Surface Interaction Studies
- Nerve injury and regeneration
- Psychosomatic Disorders and Their Treatments
- Pain Mechanisms and Treatments
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Mental Health and Psychiatry
- Hydrogels: synthesis, properties, applications
- Nanoparticle-Based Drug Delivery
- Child and Adolescent Psychosocial and Emotional Development
- Autism Spectrum Disorder Research
- Antibiotic Use and Resistance
- Mental Health Research Topics
- Neural Networks and Applications
- Protein Interaction Studies and Fluorescence Analysis
Tibet Autonomous Region People's Hospital
2018-2025
Anhui Mental Health Center
2016-2025
Jiaxing University
2021-2024
University of Alabama
2020-2024
Yunnan University of Traditional Chinese Medicine
2019-2023
Yunnan University
2021-2022
University of Toyama
2018-2021
University of Akron
2012-2019
Anhui Medical University
2018
Huai'an City Fourth People's Hospital
2018
The emergence and reemergence of microbial infection demand an urgent response to develop effective biomaterials that prevent biofilm formation associated bacterial infection. In this work, we have synthesized characterized hybrid poly(N-hydroxyethylacrylamide) (polyHEAA)/salicylate (SA) hydrogels with integrated antifouling antimicrobial capacities. efficacy polyHEAA was examined via exposure proteins, cells, bacteria, while the activity SA-treated investigated against both Gram-negative...
Major challenges in the development of effective stimuli-responsive nanogels as targeted drug and gene delivery carriers are to improve biocompatibility, stability, controlled release during systemic circulation. In this work, biofunctional based on copolymers poly(N-2-hydroxyethyl acrylamide) (polyHEAA) acrylic acid (AA) with size morphology synthesized using an inverse-microemulsion free-radical polymerization method. The chemical composition, size, swelling behavior, physical antifouling...
Despite the increase in global prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD), no approved drug currently exists for disease. Poria cocos (Schw.) Wolf (P. cocos) is a medicinal mushroom belonging to family polyporaceae widely used TCM clinics protect and treat obesity. However, its efficacy, practical components, underlying mechanism against MAFLD are yet be determined. In this study, we evaluated effects ethanol extract (EPC) on hepatic dyslipidemia, steatosis,...
Drug delivery into the peripheral nerves and nerve roots has important implications for effective local anesthesia treatment of neuropathies chronic neuropathic pain. Similar to drugs that need cross blood-brain barrier (BBB) blood-spinal cord (BSCB) gain access central nervous system (CNS), must barriers (PNB), formed by perineurium blood-nerve (BNB) modulate axons. Despite significant progress made develop strategies enhance BBB permeability in therapeutic drug design, efforts retention...
Zero-order drug release that releases drugs at a constant rate is beneficial to prolong the therapeutic effect and avoid side effects of drugs. However, due weak interaction between carrier, it particularly challenging achieve zero-order water-soluble Inspired by marker pen, which stores water-based ink in sponge core amount from tip for writing, we explore pen as delivery platform Through capillary material water, can absorb aqueous solution encapsulate store model sodium fluorescein (SF)...
Abstract Accumulating evidence shows that disruption of white matter (WM) may be involved in the pathophysiology schizophrenia, even at onset psychosis. However, very few studies have explored sex difference its association with psychopathology schizophrenia. This study aims to compare differences clinical features and WM abnormalities first-episode drug-naive (FEDN) schizophrenia among Han Chinese inpatients. The fractional anisotropy (FA) values whole-brain were determined using...
Efficient encapsulation and sustained release of small hydrophilic molecules from traditional hydrogel systems have been challenging due to the large mesh size 3D networks high water content. Furthermore, encapsulated are prone early prior use, resulting in a short shelf life formulation. Here, we present hydration-induced void-containing (HVH) based on hyperbranched polyglycerol-poly(propylene oxide)-hyperbranched polyglycerol (HPG-PPG-HPG) as robust efficient delivery system for molecules....
Abstract Previous studies have suggested that social cognition deficits, and impaired functioning, were associated with schizophrenia. However, specificity of the relationships between cues recognition functioning remain largely undefined. The authors speculated two related, further verbal non‐verbal in people A total 71 (40 schizophrenia patients 31 matched normal controls) voluntarily participated this study. Social abilities measured by eye gaze discrimination task faux pas task. was...
We synthesize and characterize two types of poly(N-hydroxyethyl acrylamide) (polyHEAA)-based nanogels: antifouling poly(2-(methacryloyloxy) ethyl trimethyl ammonium-g-N-hydroxyethyl (polyTM-g-HEAA) by a new two-step polymerization method inverse microemulsion ATRP surface-initiated atom transfer radical (SI-ATRP), pH-responsive biodegradable polyHEAA nanogels the free method. PolyTM-g-HEAA with core–shell structure grafting onto cationic polyTM core are tested for their property stability in...
Recent studies demonstrate that brain-derived neurotrophic factor (BDNF) might be associated with nicotine addiction, and circulating BDNF is a biomarker of memory general cognitive function. Moreover, suggest functional polymorphism the Val66Met may mediate hippocampal-dependent functions. We aimed to explore relationships between smoking, performance in normal Chinese Han population. recruited 628 male healthy subjects, inducing 322 smokers 306 nonsmokers, genotyped them polymorphism. Of...
The famous McCulloch–Pitts neuron model has been criticized for being overly simplistic in the long term. At same time, dendritic (DNM) shown to be effective prediction problems, and it accounts nonlinear information-processing capacity of synapses dendrites. Furthermore, since classical error back-propagation (BP) algorithm typically experiences problems caused by overabundance saddle points local minima traps, an efficient learning approach DNMs remains desirable but difficult implement....
A new type of apo-Tf functionalized nanochannel is developed to achieve the specific and selective binding unbinding Fe3+ in a multiple reversible manner via protein-conformation-gating mechanism. This ion-responsive biomimetic provides simple, robust, promising model for studying other biological processes.
Objectives: Impairments in interpersonal relationships depression present as irritability, pessimism, and withdrawal, play an important role the onset maintenance of disorder. However, we know little about neurological causes this impaired function. This study used event-related brain potential (ERP) version Cyberball paradigm to investigate emotions neural activities depressive patients during social inclusion exclusion simultaneously explore neuropsychological mechanisms. Methods:...