A5101665495- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- RNA modifications and cancer
- Advanced Neural Network Applications
- interferon and immune responses
- Traditional Chinese Medicine Analysis
- Power Line Inspection Robots
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Psychosomatic Disorders and Their Treatments
- Bioinformatics and Genomic Networks
- Image Enhancement Techniques
- Glycosylation and Glycoproteins Research
- Neurological Disease Mechanisms and Treatments
- Cancer-related Molecular Pathways
- Enhanced Recovery After Surgery
- Action Observation and Synchronization
- Hippo pathway signaling and YAP/TAZ
- Dysphagia Assessment and Management
- Chronic Lymphocytic Leukemia Research
- Ferroptosis and cancer prognosis
- Obsessive-Compulsive Spectrum Disorders
Tongji University
2023-2025
Tongji Hospital
2023-2025
Zhejiang Chinese Medical University
2023
Wuxi People's Hospital
2023
Nanjing University of Aeronautics and Astronautics
2019-2020
Hebei Medical University
2020
Ministry of Industry and Information Technology
2019
Anhui Medical University
2017
First Hospital of Qinhuangdao
2010-2015
Naval University of Engineering
2014
Insulator faults detection is an important task for high-voltage transmission line inspection. However, current methods often suffer from the lack of accuracy and robustness. Moreover, these can only detect one fault in insulator string, but cannot a multi-fault. In this paper, novel method proposed multi-fault UAV-based aerial images, backgrounds which usually contain much complex interference. The shapes insulators also vary obviously due to changes filming angle distance. To reduce impact...
Abstract Clear cell renal carcinoma (ccRCC) is the most lethal subtype of cancer, and its treatment options remain limited. Therefore, there an urgent need to discover therapeutic agents for ccRCC treatment. Here, we demonstrate that dimethyl fumarate (DMF), approved medication multiple sclerosis [1] psoriasis, can inhibit proliferation cells. Mechanistically, hepatocyte nuclear factor 1β (HNF1B), a transcription highly expressed in ccRCC, succinated by DMF at cysteine residues, leading...
Abstract Background Gastric cancer is one of the most prevalent malignant tumors within digestive system, and ferroptosis playing a crucial role in its progression. Glutathione peroxidase 4 (GPX4), key negative regulator ferroptosis, highly expressed gastric contributes to tumor growth. Targeting regulation GPX4 has emerged as promising approach induce develop effective therapy for cancer. Methods To confirm that OTUD5 deubiquitinase regulates we performed Western blotting, Co‐IP,...
The control of gluconeogenesis is critical for glucose homeostasis and the pathology type 2 diabetes (T2D). Here, we uncover a novel function TET2 in regulation gluconeogenesis. In mice, both fasting high-fat diet (HFD) stimulate expression TET2, knockout impairs production. Mechanistically, FBP1, rate-limiting enzyme gluconeogenesis, positively regulated by liver cells. recruited HNF4α, contributing to demethylation FBP1 promoter activating its response glucagon stimulation. Moreover,...
BACKGROUND: The most practical serum biomarker AFP is negative in 80% patients with small tumor the early stage of primary hepatocellular carcinoma (PHC). OBJECTIVE: To investigate significance combined tests golgi glycoprotein 73 (GP73), lens culinaris agglutinin-reactive alpha-fet oprotein (AFP-L3), glypican 3 (GPC3), des-gamma-carboxy prothrombin (DCP), CA199, ferritin (FER) and carcinoembryonic antigen (CEA) diagnosis PHC AFP. METHODS: A total 50 cases PHC, 60 non-PHC digestive system...
Objectives: Impairments in interpersonal relationships depression present as irritability, pessimism, and withdrawal, play an important role the onset maintenance of disorder. However, we know little about neurological causes this impaired function. This study used event-related brain potential (ERP) version Cyberball paradigm to investigate emotions neural activities depressive patients during social inclusion exclusion simultaneously explore neuropsychological mechanisms. Methods:...
Alexithymia is characterised by difficulties identifying and describing emotions. Few studies have investigated how alexithymia influences decision-making under different conditions (ambiguity risk). This study aimed to examine whether contributes impairment in decision-making.This included 42 participants with high scores the Chinese version of Toronto Scale (alexithymia group), 44 matched subjects low (control group). Decision-making was measured using Iowa Gambling Task (IGT) Game Dice...
Nemo-like kinase (NLK) is an evolutionarily conserved serine/threonine protein and belongs to the extracellular signal-regulated kinases/microtubule-associated families (Erks/MAPKs). Previous studies have indicated that abnormal expressions of NLK played critical roles in various types human cancers. Recent suggested expression was significantly upregulated hepatocellular carcinoma (HCC) specimens. However, clinical significance HCC remains largely unknown. In this study, we focused on found...
Human esophageal cancer (hESC) cell motility adopts various modes, resulting in hESC progression and poor survival. However, how tripartite motif 59 (TRIM59), as the ubiquitination machinery, participates metastasis is not completely understood. The results indicated that TRIM59 was aberrantly upregulated tissues compared with adjacent healthy tissues, which associated survival advanced TNM state among patients hESC. Moreover, higher expression displayed undetectable p53 expression,...
Impaired decision-making is well documented in obsessive-compulsive disorder (OCD) and a range of electrophysiological functional neuroimaging measures have begun to reveal the pathological mechanisms that underlie process. Obsessive-compulsive personality (OCPD) has core symptoms often overlap with OCD, but similarities between these disorders at behavioral neurological levels are unclear, including whether OCPD exhibits similar deficits shared dysfunction. To address issues, we examined 24...
Abstract Background A data mining algorithm is proposed based on BERTopic to provide new insights into the analysis of medication rules in Traditional Chinese Medicine (TCM) prescriptions. Methods Using algorithm, collected TCM prescriptions for corneal diseases are converted embeddings through a transformer Bidirectional Encoder Representations from Transformers pre‐trained model. Then, Uniform Manifold Approximation and Projection applied perform dimensionality reduction prescription...
The control of gluconeogenesis is critical for glucose homeostasis and the pathology type 2 diabetes (T2D). Here, we uncover a novel function TET2 in regulation gluconeogenesis. In mice, both fasting high-fat diet (HFD) stimulate expression TET2, knockout impairs production. Mechanistically, FBP1, rate-limiting enzyme gluconeogenesis, positively regulated by liver cells. recruited HNF4α, contributing to demethylation FBP1 promoter activating its response glucagon stimulation. Moreover,...
The control of gluconeogenesis is critical for glucose homeostasis and the pathology type 2 diabetes (T2D). Here, we uncover a novel function TET2 in regulation gluconeogenesis. In mice, both fasting high-fat diet (HFD) stimulate expression TET2, knockout impairs production. Mechanistically, FBP1, rate-limiting enzyme gluconeogenesis, positively regulated by liver cells. recruited HNF4α, contributing to demethylation FBP1 promoter activating its response glucagon stimulation. Moreover,...
The control of gluconeogenesis is critical for glucose homeostasis and the pathology type 2 diabetes (T2D). Here, we uncover a novel function TET2 in regulation gluconeogenesis. In mice, both fasting high-fat diet (HFD) stimulate expression TET2, knockout impairs production. Mechanistically, FBP1, rate-limiting enzyme gluconeogenesis, positively regulated by liver cells. recruited HNF4α, contributing to demethylation FBP1 promoter activating its response glucagon stimulation. Moreover,...