A5100694381- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- RNA Research and Splicing
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Liver Diseases and Immunity
- Reproductive Biology and Fertility
- Cancer Research and Treatments
- Colorectal Cancer Screening and Detection
- Renal and related cancers
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Inflammatory Biomarkers in Disease Prognosis
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Metastasis and carcinoma case studies
- Renal cell carcinoma treatment
- Immune Cell Function and Interaction
Xuzhou Medical College
2014-2025
Tongji University
2022-2025
Tongji Hospital
2023-2025
Jiangsu University
2019-2025
The University of Texas MD Anderson Cancer Center
2025
Weifang Medical University
2025
Nanjing University of Science and Technology
2023-2025
Xiamen University of Technology
2024
Nanjing General Hospital of Nanjing Military Command
2013-2024
Southern Medical University
2014-2024
Abstract Background Noncoding RNAs such as circular (circRNAs) are abundant in the human body and influence occurrence development of various diseases. However, biological functions circRNAs colorectal cancer (CRC) largely unknown. Methods RT-qPCR was used to detect expression mRNA CRC cells tissues. Fluorescence situ hybridization (FISH) analyze location circSPARC. Function-based experiments were performed using circSPARC knockdown overexpression cell lines vitro vivo, including CCK8,...
Abstract Background Long noncoding RNAs (lncRNAs) have emerged as key players in tumorigenesis and tumour progression. However, the biological functions potential mechanisms of lncRNAs colorectal cancer (CRC) are unclear. Methods The novel lncRNA POU6F2-AS1 was identified through bioinformatics analysis, its expression CRC patients verified via qRT–PCR FISH. In vitro vivo experiments, such BODIPY staining, Oil Red O triglyceride (TAG) assays, liquid chromatography mass spectrometry (LC-MS)...
Accumulating studies have revealed that aberrant expression of circular RNAs (circRNAs) is widely involved in the tumorigenesis and progression malignant cancers, including colorectal cancer (CRC). Nevertheless, clinical significance, levels, features, biological function, molecular mechanisms novel circRNAs CRC remain largely unexplored.CRC-related were identified through bioinformatics analysis verified specimens by qRT-PCR situ hybridization (ISH). Then, vitro vivo experiments performed...
The presence of bacteria in tumor results chemotherapeutic drug resistance and weakens the immune response colorectal cancer. To overcome bacterium-induced potentiate antitumor immunity, herein a novel molecule Biotin-Lys(SA-Cip-OH)-Lys(SA-CPT)-Phe-Phe-Nap (Biotin-Cip-CPT-Nap) is rationally designed containing four functional motifs (i.e., biotin motif for targeting, Phe-Phe(-Nap) self-assembly, ciprofloxacin derivative (Cip-OH) antibacterial effect, camptothecin (CPT) chemotherapy). Using...
This work aims to explore the roles and mechanisms of long non coding RNA (lncRNA) THOR in regulating stemness gastric cancer cells. RNA-sequencing combined with quantitative real-time PCR (qRT-PCR) indicated that lncRNA level was significantly upregulated tissues compared normal adjacent tissues. Knockdown attenuated stemnness cells, evident by decrease markers expression capacity cells spheroid formation. Further qRT-PCR western blot analysis demonstrated transcriptional factor SOX9...
Gastric cancer (GC) has been regarded as a kind of the most common cancers in gastrointestinal malignant tumors. Circular RNA (circRNA) is newly discovered category non-coding RNAs and plays significant role initiation or development human cancers. Nevertheless, circPIP5K1A GC remains unclear. The relative expression level circular structure were confirmedby RT-qPCR. biological function was evaluated by colony formation, transwell western blot assays. binding capacity between miR-671-5p (or...
Background . Adenosine, derived from the degradation of ATP via ectonucleotidases CD39 and CD73, is a critical immunosuppressive metabolite in hypoxic microenvironment tumor tissue. Adenosine signaling A2aR can inhibit antitumor immune response CD8 + T cells. CD73 high-expressing Tregs play role evasion gastric cancer (GC). The present study investigated underlying mechanism by which suppress responses GC. Materials Methods Fifty-two GC samples were collected, frequency FoxP3 cells density...
Abstract Inactivating mutations of von Hippel–Lindau (VHL) are highly prevalent in clear cell renal carcinoma (ccRCC). Improved understanding the vulnerabilities VHL-deficient ccRCC could lead to improved treatment strategies. The activity DNA dioxygenase ten-eleven translocation (TET)2 is significantly reduced multiple cancers by different mechanisms, but its role progression remains unclear. Here, we report that increased expression TET2, not TET1 and TET3, negatively associated with tumor...
As the second leading cause of cancer worldwide, colorectal (CRC) is associated with a poor prognosis. Although recent studies have explored prognostic markers in patients CRC, whether tissue microbes carry information remains unknown. Here, by assessing 533 CRC patients, we found that Proteobacteria (43.5%), Firmicutes (25.3%), and Actinobacteria (23.0%) dominated microbiota, which was different from gut microbiota. Moreover, two clear clusters were obtained clustering based on across all...
Abstract Colorectal cancer is the second common cause of death worldwide. Lamin B2 (LMNB2) involved in chromatin remodeling and rupture reorganization nuclear membrane during mitosis, which necessary for eukaryotic cell proliferation. However, role LMNB2 colorectal (CRC) poorly understood. This study explored biological functions progression possible molecular mechanisms. We found that was significantly upregulated primary tissues lines, compared with paired non-cancerous normal epithelium....
Abstract MAPK pathway inhibitors (MAPKi) are increasingly used in the treatment of advanced colorectal cancer, but often produce short-lived responses patients. Although acquired resistance by de novo mutations tumors have been found to reduce response some patients, additional mechanisms underlying limited durability targeting therapy remain unknown. Here, we denote new contributory tumor biology and provide insight on impact plasticity response. Analysis MAPKi treated patients revealed...
<p indent="0mm">Angiogenesis is an important factor influencing the development of solid tumors, and vascular endothelial growth receptor-2 (VEGFR2) a central regulator angiogenesis. Antibodies inhibitors against VEGFR2 have been widely used in various malignancies. However, regulatory mechanism has not fully clarified. Here, we show that D-mannose can significantly inhibit angiogenesis tumor by degrading VEGFR2. Specifically, inactivates GSK3β promoting phosphorylation at Ser9, enhances...
Abstract Background Gastric cancer is one of the most prevalent malignant tumors within digestive system, and ferroptosis playing a crucial role in its progression. Glutathione peroxidase 4 (GPX4), key negative regulator ferroptosis, highly expressed gastric contributes to tumor growth. Targeting regulation GPX4 has emerged as promising approach induce develop effective therapy for cancer. Methods To confirm that OTUD5 deubiquitinase regulates we performed Western blotting, Co‐IP,...
Macroautophagy/autophagy is the principal mechanism that mediates delivery of various cellular cargoes to lysosomes for degradation and recycling, has been reported play a crucial role in colorectal cancer (CRC) pathogenesis progression. Targeting autophagy may be promising therapeutic strategy CRC. However, specific functions potential mechanisms CRC remain unclear. In present study, we discovered PTK6 (protein tyrosine kinase 6) could activate inhibit apoptosis. physically interacted with...
ABSTRACT Despite its high preventability and curability, tuberculosis (TB) remains a leading cause of morbidity mortality worldwide. One factor that contributes to the susceptibility progression various diseases is immune escape. Therefore, primary aim our study was explore involvement escape‐related genes in pathogenesis TB. Two TB datasets retrieved from gene expression omnibus database were used identify differentially expressed (DEGs). Machine learning hub (HIERGs). Weighted...
DExD- box helicase 21 (DDX21) is overexpressed in colorectal cancer (CRC) and positively correlated with poor prognosis the malignant phenotype of CRC. Functional characterization indicated that DDX21 promotes CRC metastasis angiogenesis both vitro vivo. N-acetyltransferase 10 (NAT10) a key regulator N4-acetylcytidine (ac4C) modification mRNA, regulating stabilization mRNA via ac4C modification. Here, we identified competitive binding sirtuin 7 (SIRT7), inducing overexpression NAT10....
Anti-mullerian hormone (AMH) is thought to reflect the growth of follicles and ovarian function. However, role AMH in culture medium during vitro maturation (IVM) on oocyte quality subsequent development potential unclear. The objective this study investigate effect recombinant human (rh-AMH) supplemented into IVM quality. Cumulus-oocyte complexes (COCs) were obtained from ICR mice cultured with different concentrations (0-1,000 ng/ml) rh-AMH. Following 16-18 h culture, quantitative PCR...