A5044591858- Orthopaedic implants and arthroplasty
- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Venous Thromboembolism Diagnosis and Management
- Periodontal Regeneration and Treatments
- Knee injuries and reconstruction techniques
- 3D Printing in Biomedical Research
- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Inflammatory mediators and NSAID effects
- Spondyloarthritis Studies and Treatments
- Hip disorders and treatments
- Bone and Joint Diseases
- Blood transfusion and management
- Intramuscular injections and effects
- Heparin-Induced Thrombocytopenia and Thrombosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal synovial abnormalities and treatments
- Lower Extremity Biomechanics and Pathologies
- Electrospun Nanofibers in Biomedical Applications
- Autoimmune and Inflammatory Disorders Research
- Shoulder Injury and Treatment
- Wound Healing and Treatments
Southern Medical University
2016-2025
Nanfang Hospital
2016-2025
Over the years, electroconductive hydrogels (ECHs) have been extensively applied for stimulating nerve regeneration and restoring locomotor function after peripheral injury (PNI) with diabetes, given their favorable mechanical electrical properties identical to endogenous tissue. Nevertheless, PNI causes loss of inflammatory pain, especially in diabetic patients. It has established that bone marrow stem cells-derived exosomes (BMSCs-Exos) analgesic, anti-inflammatory tissue properties....
Purpose: Given that autologous bone graft for defects is limited by insufficient supply and morbidity at the donor site, developing biomimetic materials as an alternative has gained consistent attention. However, obstacles in designing bone-mimetic could integrate nature of extracellular matrix, osteogenic cells, osteoinductive ingredients with a fast convenient strategy still exist. Methods: This study designed fabricated mesenchymal stem cell (MSC)-laden, nanohydroxyapatite (HAP),...
Objective: A prospective, multicenter, randomized controlled trial was conducted to explore the short-term effect of a new robotic-assisted total knee arthroplasty (TKA) system, and clinical radiographic effectiveness between system conventional TKA were compared analyzed. Materials Methods: Overall, 144 patients randomly divided into two groups, wherein 72 underwent using robotic‑assisted TKA. The demographic data parameters collected. factors influencing postoperative hip–knee–ankle (HKA)...
Abstract: The development of metallic joint prostheses has been ongoing for more than a century alongside advancements in hip and knee arthroplasty. Among the materials utilized, Cobalt-Chromium-Molybdenum (Co-Cr-Mo) Titanium-Aluminum-Vanadium (Ti-Al-V) alloys are predominant prosthesis construction, predominantly due to their commendable biocompatibility, mechanical strength, corrosion resistance. Nonetheless, over time, physical wear, electrochemical corrosion, inflammation induced by...
Hemophilic articular cartilage damage presents a significant challenge for surgeons, characterized by recurrent intraarticular bleeding, severe inflammatory microenvironment, and limited self-repair capability of tissue. Currently, there is lack tissue engineering-based integrated therapies that address both early hemostasis, anti-inflammation, long-lasting chondrogenesis hemophilic defects. Herein, we developed an adhesive hydrogel using oxidized chondroitin sulfate gelatin, loaded with...
Total knee arthroplasty is regarded as the most effective treatment for severe osteoarthritis. The influential factors of blood loss in total remain controversial. study aims to explore comprehensively. Three hundred and four osteoarthritis patients undergoing unilateral primary were enrolled. Demographic characteristics, laboratory results, surgical protocol, hemostatic anticoagulation drugs collected. Estimation was calculated using Gross equation. Multivariable stepwise linear regression...
Osteochondral repair remains a challenge in clinical practice nowadays despite extensive advances tissue engineering. The insufficient recruitment of endogenous cells the early stage and incomplete cell differentiation later constitute major difficulty osteochondral repair. Here, novel all-silk-derived multifunctional biomaterial platform for engineering is reported. bilayer methacrylated silk fibroin (SilMA) hydrogel was fabricated through stratified photocuring as basic provisional matrix...
Abstract Venous thromboembolism (VTE; deep venous thrombosis and pulmonary embolism) is a known complication following primary total knee arthroplasty (TKA). The aim of this study was to investigate the trends incidence VTE after TKA identify associated risk factors for occurrence VTEs in large cohort patients. We performed retrospective which Nationwide Inpatient Sample (NIS) database used all patients who underwent over period 13 consecutive years (between 2002 2014) United States....
Autologous bone grafts are the gold standard for treating defects. However, limited supply and morbidity at donor site restrict its extensive use. Therefore, developing graft materials as an alternative to autologous has gained considerable attention. Injectable hydrogels endowed with osteogenic potential have ability fill irregular defects using minimally invasive procedures thus been attracting researchers' from a clinical perspective, most fabrication methods employed current injectable...
Postoperative delirium (POD) is a common complication after major surgery, resulting in various adverse reactions. However, incidence and risk factors associated with POD shoulder arthroplasty (SA) have not been well studied using large-scale national database.A retrospective database analysis was performed based on the Nationwide Inpatient Sample (NIS) from 2005 to 2014, largest fully paid hospital care United States. Patients undergoing SA were included. The patient's demographics,...
Abstract The meniscus is vital for maintaining knee homeostasis and function. Meniscal calcification one of the earliest radiological indicators osteoarthritis (KOA), meniscal associated with alterations in biomechanical properties. originates from a biochemical process similar to vascular calcification. Advanced glycation end products (AGEs) their receptors (RAGEs) reportedly play critical roles Herein, we investigated whether targeting AGE-RAGE potential treatment In our study,...
Macroporous calcium phosphate cement (CPC) with stem cell seeding is promising for bone regeneration. The objective of this study was to investigate the effects co-delivering autologous marrow mesenchymal cells (BMSCs) and platelet-rich plasma (PRP) in CPC scaffold regeneration minipigs first time. Twelve female adult Tibet (12–18 months old) were used. A cylindrical defect 10 mm height 8 diameter prepared at femoral condyle. Two defects created each minipig, one side Three constructs...
Abstract Objective This study sought to determine the incidence and risk factors of blood transfusion among patients undergoing total knee revision (TKR) using a nationwide database. Methods A retrospective data analysis was conducted based on Nationwide Inpatient Sample (NIS), enrolling who underwent TKR from 2010 2019 with complete information. The were divided into two groups whether they received or not. demographic characteristics (race, sex, age), length stay (LOS), charge...
In recent years, electroconductive hydrogels (ECHs) have shown great potential in promoting nerve regeneration and motor function recovery following diabetic peripheral injury (PNI), attributed to their similar electrical mechanical characteristics innate nervous tissue. It is well-established that PNI causes deficits pain, especially diabetics. Current evidence suggests ropivacaine (ROP) encapsulated poly lactic-co-glycolic acid (PLGA) microspheres (MSs) yield a sustained analgesic effect....
Abstract Although periprosthetic joint infection (PJI) has been hypothesized to increase the risk of complications following revision total knee arthroplasty (TKA), strong evidence linking two is lacking. The aim this study was determine whether PJI an independent factor for inpatient perioperative complications, and increased resource use in patients undergoing TKA. We relied on US Nationwide Inpatient Sample (NIS) identify with or non-PJI treated TKA between 2002 2014. Overall, 5,316...
Osteoarthritis (OA) is a chronic degenerative disease that primarily includes articular cartilage destruction and inflammatory reactions, effective treatments for this are still lacking. The present study aimed to explore the protective effects of ectoine, compatible solute found in nature, on chondrocytes rats its possible application OA treatment. In vitro studies, morphology after trypsin digestion 2 min viability at 50°C were observed ectoine reactive oxygen species (ROS) levels...