A5100619336- Bird parasitology and diseases
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Renal cell carcinoma treatment
- Diet and metabolism studies
- Orthopaedic implants and arthroplasty
- Spine and Intervertebral Disc Pathology
- Hip and Femur Fractures
- Ferroptosis and cancer prognosis
- Viral gastroenteritis research and epidemiology
- Radiomics and Machine Learning in Medical Imaging
- Gut microbiota and health
- Inflammatory Biomarkers in Disease Prognosis
- Insect Resistance and Genetics
- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- Folate and B Vitamins Research
- Cancer, Hypoxia, and Metabolism
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- Bone health and osteoporosis research
- Helminth infection and control
- Vestibular and auditory disorders
- Orthopedic Infections and Treatments
- Photodynamic Therapy Research Studies
Union Hospital
2022-2025
Shanghai Municipal Center For Disease Control Prevention
2022-2025
The First Affiliated Hospital, Sun Yat-sen University
2021-2025
Huazhong University of Science and Technology
2022-2025
Nanfang Hospital
2020-2025
First People's Hospital of Foshan
2023-2025
Southern Medical University
2020-2025
Chongqing City Mental Health Center
2024-2025
Yangzhou University
2022-2025
Shanghai Institute of Technology
2025
Implant-associated infection (IAI) caused by pathogens colonizing on the implant surface is a serious issue in trauma-orthopedic surgery, which often leads to failure. The complications of IAI bring big threat clinical practice implants, accompanied significant economic cost and long hospitalization time. In this study, we propose an antibiotics-free strategy address IAI-related challenges using biodegradable cytocompatible hydrogel coating. To achieve this, novel system was developed...
Oxidative stress is one of the main driving mechanisms intervertebral disc degeneration(IDD). has been associated with inflammation in disc, cellular senescence, autophagy, and epigenetics cells. It above pathological are closely linked through common hub reactive oxygen species(ROS), promote each other process degeneration development disease. This reveals important role oxidative IDD, importance great potential IDD therapy targeting stress. The efficacy traditional unstable or cannot be...
Abstract: The development of metallic joint prostheses has been ongoing for more than a century alongside advancements in hip and knee arthroplasty. Among the materials utilized, Cobalt-Chromium-Molybdenum (Co-Cr-Mo) Titanium-Aluminum-Vanadium (Ti-Al-V) alloys are predominant prosthesis construction, predominantly due to their commendable biocompatibility, mechanical strength, corrosion resistance. Nonetheless, over time, physical wear, electrochemical corrosion, inflammation induced by...
Abstract Increasing evidences show the clinical significance of interaction between hypoxia and immune in clear cell renal carcinoma (ccRCC) microenvironment. However, reliable prognostic signatures based on a combination have not been well established. Moreover, many studies only used RNA-seq profiles to screen prognosis feature ccRCC. Presently, there is no comprehensive analysis multiomics data mine better one. Thus, we try get it. First, t-SNE ssGSEA were establish tumor subtypes related...
BackgroundImproved markers for predicting recurrence are needed to stratify patients with localised (stage I–III) renal cell carcinoma after surgery selection of adjuvant therapy. We developed a novel assay integrating three modalities—clinical, genomic, and histopathological—to improve the predictive accuracy recurrence.MethodsIn this retrospective analysis validation study, we histopathological whole-slide image (WSI)-based score using deep learning allied digital scanning conventional...
The combined effects of fertilization and drought stress on the growth of Prunella vulgarisand production rosmarinic acid (RA), ursolic (UA) oleanolic (OA) were investigated. factors studied included two water conditions three fertilizer regimes. results showed that moderate dramatically decreases spica biomass but increases content RA, UA OA in spicas of P. vulgaris. Total yields found to be significantly higher well-watered plants than drought-stressed plants. An appropriate amount could...
OBJECTIVE Type 2 diabetes is related to obesity and altered bone health, both are affected by gut microbiota. We examined associations of weight loss diet–induced changes in a microbiota–related metabolite trimethylamine N-oxide (TMAO), its precursors (choline l-carnitine), with mineral density (BMD) considering diabetes-related factors. RESEARCH DESIGN AND METHODS In the 2-year Preventing Overweight Using Novel Dietary Strategies trial (POUNDS Lost), 264 overweight obese participants...
Endothelial progenitor cells (EPCs) are reduced in number and impaired function diabetic patients. Whether how Nrf2 regulates the of EPCs remains unclear. In this study, we found that expression its downstream genes were decreased from both patients db/db mice. Survival ability angiogenic mice also impaired. Gain- loss-of-function studies, respectively, showed knockdown increased apoptosis tube formation healthy donors wild-type mice, while overexpression rescued Additionally, proangiogenic...
Pyroptosis and necroptosis are two recently identified forms of immunogenic cell death in the tumor microenvironment (TME), indicating a crucial involvement metastasis. However, characteristics pyroptosis that define prognosis ccRCC patients remain unknown. We systematically investigated transcriptional variation expression patterns Necroptosis related genes (NPRGs). After screening necroptosis-pyroptosis clusters, potential functional annotation for clusters was explored by GSVA enrichment...
Abstract Intervertebral disc degeneration (IVDD) is characterized by the senescence and declining vitality of nucleus pulposus cells (NPCs), often driven mitochondrial dysfunction. This study elucidates that mesenchymal stem (MSCs) play a crucial role in attenuating NPC secreting mitochondria-containing microvesicles (mitoMVs). Moreover, it demonstrates static magnetic fields (SMF) enhance secretion mitoMVs MSCs. By distinguishing mitoMV generation from exosomes, this shifts focus to...
Defects in chaperone-mediated autophagy (CMA) are associated with cellular senescence, but the mechanism remains poorly understood. Here, we found that CMA inhibition induced senescence a calcium-dependent manner and identified its role TNF-induced of nucleus pulposus cells (NPC) intervertebral disc degeneration. Based on structural functional proteomic screens, PLCG1 (phospholipase C gamma 1) was predicted as potential substrate for deficiency to affect calcium homeostasis. We further...
The effects of UV-B radiation on the content bioactive components and antioxidant activity Prunella vulgaris L. spica during development were studied. experimental design involved two levels intensity (0 120 μW cm-2 nm-1). results showed that contents total flavonoids, rosmarinic acid, caffeic acid hyperoside, as well capacities (DPPH● ABTS•+ scavenging activities), in spicas significantly decreased development. salviaflaside increased highest activities found full-flowering stage, while...
Abstract Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome (MetS) and has been correlated with coronary atherosclerosis (CAS). Since NAFLD was renamed metabolic-associated disease(MAFLD) in 2020, no studies have evaluated correlation between MAFLD CAS. The aim this study to evaluate relationship A total 1330 patients underwent continuous computed tomography angiography (CCTA) abdominal ultrasound as part a routine physical examination....
Prunella vulgaris is an important material for Chinese medicines with rosmarinic acid (RA) as its index component. Based on the chromosome-level genome assembly we obtained recently, 51 RA biosynthesis-related genes were identified. Sequence feature, gene expression pattern and phylogenetic relationship analyses showed that 17 of them could be involved in biosynthesis. In vitro enzymatic assay PvRAS3 catalyzed condensation p -coumaroyl-CoA caffeoyl-CoA pHPL DHPL. Its affinity toward was...
Abstract Integrating genomics and histology for cancer prognosis demonstrates promise. Here, we develop a multi-classifier system integrating lncRNA-based classifier, deep learning whole-slide-image-based clinicopathological classifier to accurately predict post-surgery localized (stage I–III) papillary renal cell carcinoma (pRCC) recurrence. The significantly higher predictive accuracy recurrence-free survival (RFS) compared the three single classifiers alone in training set both validation...
Schisandrin B is an active component isolated from Schisandra chinensis (TurcZ.) Baill. that widely used as antihepatotoxic agent. has significant hepatoprotective effect against chemical and immunological liver injury. This study aimed to investigate the of on expression 27- 70-kDa heat-shock protein (HSP) its role in protection acetaminophen-induced injury mice.After mice were pretreated, Western blot real-time quantitative polymerase chain reaction detect gene HSP27 HSP70, respectively;...
As regulations ban legacy PFASs, many emerging PFASs are being developed, leading to their release into the aquatic environment and drinking water. However, research studies on these in water limited, current standards only cover a few leaving unregulated toxicity unknown. Therefore, machine learning-based suspect screening combined with target was employed comprehensively identify quantify both novel from Yangtze River Delta, potential sources of contamination were determined through...