A5078153147- Viral Infections and Vectors
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Respiratory viral infections research
- Mosquito-borne diseases and control
- Spine and Intervertebral Disc Pathology
- COVID-19 Clinical Research Studies
- Musculoskeletal pain and rehabilitation
- Vector-Borne Animal Diseases
- Vector-borne infectious diseases
- Bacillus and Francisella bacterial research
- COVID-19 Digital Contact Tracing
- Air Quality and Health Impacts
- Nitric Oxide and Endothelin Effects
- Zoonotic diseases and public health
- Spondyloarthritis Studies and Treatments
- Fire effects on ecosystems
- SARS-CoV-2 detection and testing
- Image Enhancement Techniques
- Inflammatory mediators and NSAID effects
- Selenium in Biological Systems
- Music Therapy and Health
- COVID-19 Impact on Reproduction
- Heavy Metals in Plants
Union Hospital
2023-2025
Huazhong University of Science and Technology
2023-2025
Qilu Hospital of Shandong University
2022-2025
University of Alberta
2023-2025
Pudong New Area People's Hospital
2025
Shanghai Municipal Center For Disease Control Prevention
2023-2024
Beijing University of Civil Engineering and Architecture
2024
Zhengzhou University
2024
Bridge University
2023
Peking University
2023
Our manuscript was based on surveillance cases of COVID-19 identified before January 26, 2020. As February 20, 2020, the total number confirmed in mainland China has reached 18 times our manuscript. While methods and main conclusions original analyses remain solid, we decided to withdraw this preprint for time being, will replace it with a more up-to-date version shortly. Should you have any comments or suggestions, please feel free contact corresponding author.
Nationwide prospective surveillance of all-age patients with acute respiratory infections was conducted in China between 2009‒2019. Here we report the etiological and epidemiological features 231,107 eligible enrolled this analysis. Children <5 years old school-age children have highest viral positivity rate (46.9%) bacterial (30.9%). Influenza virus, syncytial virus human rhinovirus are three leading pathogens proportions 28.5%, 16.8% 16.7%, Streptococcus pneumoniae, Mycoplasma pneumoniae...
Oxidative stress is one of the main driving mechanisms intervertebral disc degeneration(IDD). has been associated with inflammation in disc, cellular senescence, autophagy, and epigenetics cells. It above pathological are closely linked through common hub reactive oxygen species(ROS), promote each other process degeneration development disease. This reveals important role oxidative IDD, importance great potential IDD therapy targeting stress. The efficacy traditional unstable or cannot be...
Loss of Bcl2-associated athanogene 3 (BAG3) is associated with dilated cardiomyopathy (DCM). BAG3 regulates sarcomere protein turnover in cardiomyocytes; however, the function other cardiac cell types understudied. In this study, we used an isogenic pair BAG3-knockout and wild-type human induced pluripotent stem cells (hiPSCs) to interrogate role hiPSC-derived fibroblasts (CFs). Analysis type-specific conditional knockout engineered heart tissues revealed essential contribution CF...
Abstract Background As of April 2, 2020, the global reported number COVID-19 cases has crossed over 1 million with more than 55,000 deaths. The household transmissibility SARS-CoV-2, causative pathogen, remains elusive. Methods Based on a comprehensive contact-tracing dataset from Guangzhou, we estimated both population-level effective reproductive and individual-level secondary attack rate (SAR) in setting. We assessed age effects infectivity during their incubation period. Results A total...
The vaccination rate for seasonal influenza remains low in most regions of China. It is essential to understand the factors that associated with various populations after COVID-19 pandemic. A cross-sectional survey was conducted residents Pudong New Area, Shanghai, Respondents' condition during 2021–2022 flu season and reasons receiving or not vaccine were investigated. Binary logistic regression explore potential influencing uptake. 2,476 14,001 respondents received an vaccine, a total...
Abstract Background COVID-19 has impacted populations around the world, with fatality rate varying dramatically across countries. Selenium, as one of important micronutrients implicated in viral infections, was suggested to play roles. Methods An ecological study performed assess association between related and selenium content both from crops topsoil, China. Results Totally, 14,045 cases were reported 147 cities during 8 December 2019–13 2020 included. Based on crops, case rates (CFRs)...
Abstract Background The ongoing transmission of the Middle East respiratory syndrome coronavirus (MERS-CoV) in and its expansion to other regions are raising concerns a potential pandemic. An in-depth analysis about both population molecular epidemiology this pathogen is needed. Methods MERS cases reported globally as June 2020 were collected mainly from World Health Organization official reports, supplemented by reliable sources. Determinants for case fatality spatial diffusion assessed...
Abstract Intervertebral disc degeneration (IVDD) is characterized by the senescence and declining vitality of nucleus pulposus cells (NPCs), often driven mitochondrial dysfunction. This study elucidates that mesenchymal stem (MSCs) play a crucial role in attenuating NPC secreting mitochondria-containing microvesicles (mitoMVs). Moreover, it demonstrates static magnetic fields (SMF) enhance secretion mitoMVs MSCs. By distinguishing mitoMV generation from exosomes, this shifts focus to...
Defects in chaperone-mediated autophagy (CMA) are associated with cellular senescence, but the mechanism remains poorly understood. Here, we found that CMA inhibition induced senescence a calcium-dependent manner and identified its role TNF-induced of nucleus pulposus cells (NPC) intervertebral disc degeneration. Based on structural functional proteomic screens, PLCG1 (phospholipase C gamma 1) was predicted as potential substrate for deficiency to affect calcium homeostasis. We further...
Reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants due to immune escape is challenging for the global response pandemic. We estimated Omicron reinfection prevalence among people who had a previous SARS-CoV-2 infection in Shanghai, China. conducted telephone survey December 2022 those previously been infected between March and May 2022. Information on their demographics, disease 2019 (COVID-19) testing, vaccination history was collected. The overall...
The concurrent impact of COVID-19 and influenza on disease burden is a topic great concern. This discussion delves into the epidemiological characteristics seasonal activity in Shanghai within context SARS-CoV-2 epidemic.
Understanding the relative transmissibility of SARS-CoV-2 virus across different contact settings and possibility superspreading events is important for prioritizing disease control. Such assessment requires proper consideration individual level exposure history, which made possible by tracing.
This study characterized Human metapneumovirus (HMPV) infection epidemiology and clinical features in patients with acute respiratory infections (ARIs) Pudong New Area, Shanghai, China, compared by pre- post-COVID-19 periods. Between January 2014 December 2023, the basic information, as well tract specimens from ARIs, were collected at 14 sentinel hospitals Shanghai Pudong. Specimens tested for HMPV other pathogens. The positivity rates analyzed age, period (pre- post-COVID-19), season, case...
Abstract. The mixing states and aging timescale of aerosol particles play a vital role in evaluating their climate effects. Here, by using field measurements at site urban Beijing, we have identified four different real-time patterns size-resolved particles, which are defined as less hygroscopic (LH) internally mixed, externally transitional mixed more (MH) with atmospheric fractions 0 %–10 %, 20 %–46 17 %–24 % 27 %–56 respectively. fraction depends on particle size, the maximum MH 80 110 nm...
BackgroundBefore effective vaccines become widely available, sufficient understanding of the impacts climate, human movement and non-pharmaceutical interventions on transmissibility COVID-19 is needed but still lacking.MethodsWe collected by crowdsourcing a database 11 003 cases from 305 cities outside Hubei Province December 31, 2019 to April 27, 2020. We estimated daily reproduction numbers (Rt) in 41 where crowdsourced case data are comparable official surveillance data. The...
Viral pathogens belonging to the order Bunyavirales pose a continuous background threat global health, but fact remains that they are usually neglected and their distribution is still ambiguously known. We aim map geographical of viruses assess environmental suitability transmission risk major in China.
Epidemics are dangerous and difficult to prevent control, especially in urban areas. Clarifying the correlation between COVID-19 Outbreak Frequency spatial environment may help improve cities’ ability respond such public health emergencies. In this study, we firstly analyzed distribution characteristics of by correlating geographic locations epidemic-affected neighborhoods city Beijing with time point onset. Secondly, created a geographically weighted regression model combining external...