A5028308787- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- Cell Image Analysis Techniques
- Prostate Cancer Treatment and Research
- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Chromatin Remodeling and Cancer
- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Ferroptosis and cancer prognosis
- Infant Development and Preterm Care
- Melanoma and MAPK Pathways
- Lung Cancer Research Studies
- Neonatal Respiratory Health Research
- Immune cells in cancer
- Prostate Cancer Diagnosis and Treatment
- Proteoglycans and glycosaminoglycans research
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Organ Transplantation Techniques and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Cancer Research and Treatments
- Fibroblast Growth Factor Research
Columbia University
2020-2025
Columbia University Irving Medical Center
2017-2025
National Center on Addiction and Substance Abuse at Columbia University
2024
Epic Sciences (United States)
2021
Convergent Science (United States)
2021
University of Southern California
2021
Beth Israel Deaconess Medical Center
2015-2019
Swift Engineering (United States)
2015
McMaster Children's Hospital
2014
McMaster University
1998
Loss of Bcl2-associated athanogene 3 (BAG3) is associated with dilated cardiomyopathy (DCM). BAG3 regulates sarcomere protein turnover in cardiomyocytes; however, the function other cardiac cell types understudied. In this study, we used an isogenic pair BAG3-knockout and wild-type human induced pluripotent stem cells (hiPSCs) to interrogate role hiPSC-derived fibroblasts (CFs). Analysis type-specific conditional knockout engineered heart tissues revealed essential contribution CF...
We propose a new approach to lung regeneration by replacement of damaged epithelium with full preservation vasculature.
Abstract TP53 mutations are frequent in esophageal squamous cell carcinoma (ESCC) and other SCCs associated with a proclivity for metastasis. Here, we report that colony-stimulating factor-1 (CSF-1) expression is upregulated significantly p53-R172H–dependent manner metastatic lung lesions of ESCC. The CSF-1 signaling, through its cognate receptor CSF-1R, increases tumor invasion metastasis, which turn mediated part Stat3 phosphorylation epithelial-to-mesenchymal transition (EMT). In...
The number of available donor organs limits lung transplantation, the only lifesaving therapy for increasing population patients with end-stage disease. A prevalent etiology injury that renders lungs unacceptable transplantation is gastric aspiration, a deleterious insult to pulmonary epithelium. Currently, severely damaged cannot be salvaged existing devices or methods. Here we report regeneration repaired meet criteria by utilizing an interventional cross-circulation platform in clinically...
ObjectivesLung remains the least-utilized solid organ for transplantation. Efforts to recover donor lungs with reversible injuries using ex vivo perfusion systems are limited <24 hours of support. Here, we demonstrate feasibility extending normothermic extracorporeal lung support 4 days cross-circulation conscious swine.MethodsA swine behavioral training program and custom enclosure were developed enable multiday between recipient swine. Lungs ventilated perfused in a chamber days....
Abstract Metastatic castration-resistant prostate cancer (mCRPC) includes a subset of patients with particularly unfavorable prognosis characterized by combined defects in at least two three tumor suppressor genes: PTEN, RB1, and TP53 as aggressive variant molecular signature (AVPC-MS). We aimed to identify circulating cells (CTC) signatures that could inform treatment decisions mCRPC cabazitaxel–carboplatin combination therapy versus cabazitaxel alone. Liquid biopsy samples were collected...
Subintimal dissection with acute occlusion of the internal carotid artery resulting in cerebral infarction has not been reported as an iatrogenic complication general anesthesia. An anesthetist stretched neck a 44-year-old man by anchoring anesthesia mask posterior to angle jaw overlying fingers patient struggled during insufficient inhalational anesthetic. A 33-year-old received endotracheal anesthetic without struggle, but he was turned from supine prone position, his head and were...
The authors describe a case of unfractionated heparin (UFH) unresponsiveness in the operating room secondary to reversal rivaroxaban with coagulation factor Xa (recombinant) inactivated-zhzo (andexanet alfa). A 70-year-old man known 4.5- 5.0-cm abdominal aortic aneurysm and atrial fibrillation managed presented severe right-sided flank pain radiating left side his abdomen. Computed tomography-angiography on arrival demonstrated retroperitoneal hematoma suspected ruptured aneurysm. He...
Abstract Mutations in the tumor suppressor gene TP53 correlate with poor prognosis and high metastasis rates, which account for more than 90% of cancer-related mortality worldwide. Our recent work, published Cancer Discovery (PMC10841313), highlights that mutant may exhibit neomorphic gain-of-function (GOF) properties, driving squamous cell carcinoma (SCC) beyond its classic role via wild-type loss. To elucidate novel p53-dependent mechanisms promoting metastasis, we first focused on one...
Abstract Tumor extracellular matrices (ECM) exhibit aberrant changes in composition and mechanics compared to normal tissues. Proteoglycans (PG) are vital regulators of cellular signaling the ECM with ability modulate receptor tyrosine kinase (RTK) activation via their sulfated glycosaminoglycan (sGAG) side chains. However, role on tumor cell behavior is controversial. Here, it demonstrated that PGs heavily expressed lung adenocarcinoma (LUAD) patients correlation invasive phenotype poor...
e17039 Background: Schlafen 11 (SLFN11) is a DNA repair protein (DNA/RNA helicase homology) that recruited to stressed replication forks and leads cell death. Recent ph II trial data in Extensive Stage Small-Cell Lung Cancer (ES-SCLC) [Byers et al. JCO 2018 PMID: 29906251] retrospective analysis of Circulating Tumor Cells (CTCs) tumor tissue patients (Pts) with advanced prostate cancer [Conteduca Mol Therapeutics 2020 32127465] suggested SLFN11 expression predicts sensitivity damage...
Abstract INTRODUCTION: Metastasis is associated with more than 90% of cancer-related mortality, and thus, there a compelling need for innovative therapeutic breakthroughs. TP53 mutations are present in 60-70% human cancers, especially squamous cell cancers. For example, detected up to 80% esophageal carcinomas (ESCCs). Accumulating evidence suggests that certain missense mutant forms p53 such as R175 (R172 mouse), R273 R282 can acquire neomorphic pro-oncogenic activities referred...
<div>Abstract<p><i>TP53</i> mutations are frequent in esophageal squamous cell carcinoma (ESCC) and other SCCs associated with a proclivity for metastasis. Here, we report that colony-stimulating factor-1 (CSF-1) expression is upregulated significantly p53-R172H–dependent manner metastatic lung lesions of ESCC. The CSF-1 signaling, through its cognate receptor CSF-1R, increases tumor invasion metastasis, which turn mediated part Stat3 phosphorylation...
Abstract Cancer-associated fibroblasts (CAFs) are a heterogenous cell population that can promote esophageal cancer progression through multiple molecular mechanisms including increased proliferation and migration, immunosuppression, therapeutic resistance. Despite the divergence of CAFs from normal with regards to phenotype functions, rarely exhibit widespread genetic alterations. Instead, it is proposed regulated at epigenetic level. Our objective delineate this regulation in cancer....