A5013094514- Respiratory Support and Mechanisms
- TGF-β signaling in diseases
- Organ Transplantation Techniques and Outcomes
- Electrostatic Discharge in Electronics
- Aortic Disease and Treatment Approaches
- Liver Disease and Transplantation
- Restraint-Related Deaths
- Neonatal Respiratory Health Research
- Cardiac pacing and defibrillation studies
- Tracheal and airway disorders
- Connective Tissue Growth Factor Research
- Cystic Fibrosis Research Advances
- Heterotopic Ossification and Related Conditions
- Nursing Diagnosis and Documentation
- Music Therapy and Health
- Mechanical Circulatory Support Devices
- Biomedical Ethics and Regulation
- Airway Management and Intubation Techniques
- Transplantation: Methods and Outcomes
- Xenotransplantation and immune response
- Cardiac Valve Diseases and Treatments
- Bone Metabolism and Diseases
- Cardiac electrophysiology and arrhythmias
- Phonocardiography and Auscultation Techniques
- Organ Donation and Transplantation
Columbia University
2021-2024
Columbia University Irving Medical Center
2020-2024
Mount Sinai Hospital
2021-2023
University of Michigan
2017-2019
Abstract Pulmonary air leak is the most common complication of lung surgery, contributing to post‐operative morbidity in up 60% patients; yet, there no reliable treatment. Available surgical sealants do not match demanding deformation mechanics tissue; and therefore, fail seal leak. To address this therapeutic gap, a sealant with structural mechanical similarity subpleural designed, developed, systematically evaluated. This “lung‐mimetic” hydrofoam material that has alveolar‐like porous...
Aberrant wound healing presents as inappropriate or insufficient tissue formation. Using a model of musculoskeletal injury, we demonstrate that loss transforming growth factor-β activated kinase 1 (TAK1) signaling reduces formation (heterotopic ossification) through reduced cellular differentiation. Upon identifying increased proliferation with TAK1 signaling, considered regenerative approach to address production coordinated inactivation promote proliferation, followed by reactivation...
Although machine perfusion has gained momentum as an organ preservation technique in liver transplantation, persistent shortages and high waitlist mortality highlight unmet needs for improved salvage strategies. Beyond preservation, extracorporeal support platforms can also aid the development evaluation of novel therapeutics. Here, we report use veno-arterial-venous (V-AV) cross-circulation (XC) with a swine host to provide normothermic livers. Functional, biochemical, morphological...
ABSTRACT Despite over 30 years of intensive research for targeted therapies, treatment acute respiratory distress syndrome (ARDS) remains supportive in nature. With mortality upwards 30%, a high-fidelity pre-clinical model ARDS, on which to test novel therapeutics, is urgently needed. We used the Yorkshire breed swine induce reproducible ARDS human-sized allow study new from both mechanistic and clinical standpoints. For this, animals were anesthetized, intubated mechanically ventilated,...
Pulmonary air leak is the most common complication of lung surgery, with leaks that persist longer than 5 days representing a major source post-surgery morbidity. Clinical management challenging due to limited methods precisely locate and assess leaks. Here, we present sound-guided methodology enables rapid quantitative assessment precise localization by analyzing distinct sounds generated as escapes through defective tissue. Air often after surgery loss tissue integrity at or near staple...
A 26-year-old man with hypertrophic obstructive cardiomyopathy and an automatic implantable cardioverter-defibrillator (AICD) sustained a gunshot injury to the left side of his chest wall, resulting in direct impact bullet into AICD generator. The resulted dent outer case along damage generator battery device deactivation. There was no associated intrathoracic injury. successfully replaced, patient discharged. This report describes comprehensive analysis management this extraordinary young...
Purpose: Bone tissue engineering remains hampered by inadequate scaffold design and regulatory limitations on autologous cell use. We developed a novel system to silence reactivate TGF-ß activating kinase 1 (TAK1), which mediates TGF-β1 BMP2. hypothesize that Tak1 can be initially silenced increase local proliferation followed reactivation stimulate bone differentiation, providing cell-free healing. Methods: dual-recombinase (Cre/lox; FLP/FRT) allow silencing of Tak1. Critical...