A5100365595- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Computational Drug Discovery Methods
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- interferon and immune responses
- Sperm and Testicular Function
- SARS-CoV-2 detection and testing
- Phytochemicals and Antioxidant Activities
- Lipid metabolism and biosynthesis
- Machine Learning in Materials Science
- Microbial Natural Products and Biosynthesis
- Machine Learning in Bioinformatics
- RNA and protein synthesis mechanisms
- Receptor Mechanisms and Signaling
- Lipid Membrane Structure and Behavior
- Marine Sponges and Natural Products
- Long-Term Effects of COVID-19
- Reproductive Biology and Fertility
- Protein Structure and Dynamics
- RNA modifications and cancer
- Plant tissue culture and regeneration
- Oil Palm Production and Sustainability
- Cell death mechanisms and regulation
- Gene Regulatory Network Analysis
Sichuan University
2018-2025
State Grid Corporation of China (China)
2025
Tianjin University of Traditional Chinese Medicine
2025
Guangxi Normal University
2024-2025
State Key Laboratory of Biotherapy
2020-2025
Guizhou Provincial People's Hospital
2025
University of South China
2025
University of California, Berkeley
2025
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2025
Beijing YouAn Hospital
2025
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continually poses serious threats to global public health. main protease (Mpro) of SARS-CoV-2 plays a central role in viral replication. We designed and synthesized 32 new bicycloproline-containing Mpro inhibitors derived from either boceprevir or telaprevir, both which are approved antivirals. All compounds inhibited activity vitro, with 50% inhibitory concentration values ranging 7.6 748.5 nM....
Nationwide prospective surveillance of all-age patients with acute respiratory infections was conducted in China between 2009‒2019. Here we report the etiological and epidemiological features 231,107 eligible enrolled this analysis. Children <5 years old school-age children have highest viral positivity rate (46.9%) bacterial (30.9%). Influenza virus, syncytial virus human rhinovirus are three leading pathogens proportions 28.5%, 16.8% 16.7%, Streptococcus pneumoniae, Mycoplasma pneumoniae...
Abstract National-based prospective surveillance of all-age patients with acute diarrhea was conducted in China between 2009‒2018. Here we report the etiological, epidemiological, and clinical features 152,792 eligible enrolled this analysis. Rotavirus A norovirus are two leading viral pathogens detected patients, followed by adenovirus astrovirus. Diarrheagenic Escherichia coli nontyphoidal Salmonella bacterial pathogens, Shigella Vibrio parahaemolyticus . Patients aged <5 years had...
Abstract Emerging SARS-CoV-2 variants, particularly the Omicron variant and its sublineages, continually threaten global public health. Small molecule antivirals are an effective treatment strategy to fight against virus. However, first-generation either show limited clinical efficacy and/or have some defects in pharmacokinetic (PK) properties. Moreover, with increased use of these drugs across globe, they face great pressure drug resistance. We herein present discovery characterization a...
The ongoing coronavirus disease 2019 (COVID-19) pandemic has caused >20 million infections and >750,000 deaths. Severe acute respiratory syndrome 2 (SARS-CoV-2), the etiological agent of COVID-19, been found closely related to bat strain RaTG13 (Bat-CoV RaTG13) a recently identified pangolin (Pangolin-CoV-2020). Here, we first investigated ability SARS-CoV-2 three coronaviruses utilize animal orthologs angiotensin-converting enzyme (ACE2) for cell entry. We that ACE2 wide range domestic wild...
The outbreak of pneumonia caused by SARS-CoV-2 posed a great threat to global human health, which urgently requires us understand comprehensively the mechanism infection.Angiotensin-converting enzyme 2 (ACE2) was identified as functional receptor for SARS-CoV-2, distribution may indicate risk different organs vulnerable infection.Previous studies investigating ACE2 mRNA in tissues only involved limited size samples and lack determination protein.Given heterogeneity among humans, datasets...
The retrieval of hit/lead compounds with novel scaffolds during early drug development is an important but challenging task. Various generative models have been proposed to create drug-like molecules. However, the capacity these design wet-lab-validated and target-specific molecules has hardly verified. We herein propose a deep learning (GDL) model, distribution-learning conditional recurrent neural network (cRNN), generate tailor-made virtual compound libraries for given biological targets....
Cladosporium, a genus of ascomycete fungi in the Dematiaceae family, is primarily recognized as widespread environmental saprotrophic fungus or plant endophyte. Further research has shown that distributed various environments, particularly marine ecosystems, such coral reefs, mangroves and polar region. especially marine-derived highly resourceful group whose natural products have garnered attention due to their diverse chemical structures biological activities, well potential sources novel...
This study aims to assess the relationship between modifiable dementia risk factors and both cognitive decline. Data were obtained from Health Retirement Study (HRS) [2008-2020], China Longitudinal (CHARLS) [2011-2020], English of Ageing (ELSA) [2010-2020]. After adjusting for confounding factors, multivariable logistic regression was utilized analyze dementia, while linear employed examine these Additionally, Cox proportional hazards model used number factor events, clusters, risk. A total...
Abstract Background Astrocytoma is a common aggressive intracranial tumor and presents formidable challenge in the clinic. Association of altered DNA methylation patterns promoter CpG islands with expression profile cancer-related genes, has been found many human tumors. Therefore, status as such may serve an epigenetic biomarker for both diagnosis prognosis tumors, including astrocytoma. Methods We used specific PCR conjunction sequencing verification to establish island thirty four genes...
This study established an MMP-2/pH dual-sensitive, multistage nanoparticle, DGL/DOX@PP, that can release small nanoparticles through the simple breakage of enzyme-sensitive bond.
Non pharmaceutical interventions (NPI) including hand washing directives were implemented in China and worldwide to combat the COVID-19 pandemic, which are likely have had impacted a broad spectrum of enteric pathogen infections.Etiologically diagnostic data from 45 937 67 395 patients with acute diarrhea between 2012 2020, who tested for seven viral pathogens 13 bacteria respectively, analyzed assess changes infections during first pandemic year compared pre-pandemic years.Test positive...
Capsule networks (CapsNets), a new class of deep neural network architectures proposed recently by Hinton et al., have shown great performance in many fields, particularly image recognition and natural language processing. However, CapsNets not yet been applied to drug discovery-related studies. As the first attempt, we this investigation adopted develop classification models hERG blockers/nonblockers; drugs with blockade activity are thought potential risk cardiotoxicity. Two capsule were...
GPR34 is a functional G-protein-coupled receptor of Lysophosphatidylserine (LysoPS), and has pathogenic roles in numerous diseases, yet remains poorly targeted. We herein report cryo-electron microscopy (cryo-EM) structure bound with LysoPS (18:1) G i protein, revealing unique ligand recognition mode the negatively charged head group occupying polar cavity formed by TM3, 6 7, hydrophobic tail residing lateral open groove TM3-5. Virtual screening subsequent structural optimization led to...
AimTo describe the clinical characteristics and risk factors associated with progression of COVID-19 in elderly diabetes patients.MethodsThis was a retrospective cohort study, including patients admitted to Wuhan Huoshenshan Hospital between February 10 13, 2020. Demographic data, medical history, signs symptoms, laboratory parameters were collected analysed.ResultsWe included 131 (50 diabetes). experienced more severe pneumonia abnormal organ functions than non-diabetes (P < 0.05 or P...