A5100397325- Platelet Disorders and Treatments
- Computational Drug Discovery Methods
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Biological and pharmacological studies of plants
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Cancer Treatment and Pharmacology
- Galectins and Cancer Biology
- Cancer-related gene regulation
- Protein Tyrosine Phosphatases
- Venous Thromboembolism Diagnosis and Management
- Ubiquitin and proteasome pathways
- Angiogenesis and VEGF in Cancer
- Atrial Fibrillation Management and Outcomes
- Ginseng Biological Effects and Applications
- Protein Degradation and Inhibitors
- Chronic Myeloid Leukemia Treatments
- Cardiac Arrest and Resuscitation
- Pharmacovigilance and Adverse Drug Reactions
- Bone Metabolism and Diseases
- Chemotherapy-induced organ toxicity mitigation
- Heterotopic Ossification and Related Conditions
- Subtitles and Audiovisual Media
- Medicinal Plant Pharmacodynamics Research
Sichuan University
2012-2025
Shenyang Medical College
2025
Light Industry Hangzhou Electromechanical Design Institute
2025
Southwest Medical University
2015-2024
China University of Geosciences
2024
Northwest Normal University
2024
Nanjing Foreign Language School
2024
Zigong First People's Hospital
2023
Affiliated Hospital of Southwest Medical University
2023
State Key Laboratory of Biotherapy
2020-2022
Capsule networks (CapsNets), a new class of deep neural network architectures proposed recently by Hinton et al., have shown great performance in many fields, particularly image recognition and natural language processing. However, CapsNets not yet been applied to drug discovery-related studies. As the first attempt, we this investigation adopted develop classification models hERG blockers/nonblockers; drugs with blockade activity are thought potential risk cardiotoxicity. Two capsule were...
SET domain bifurcated protein 1 (SETDB1) is a histone lysine methyltransferase that promotes the silencing of some tumour suppressor genes and overexpressed in many cancers. SETDB1 contains unique tandem tudor (TTD) recognizes H3 sequences containing both methylated acetylated lysines. Beginning with identification hit compound (Cpd1), we discovered first potent selective small molecule SETDB1-TTD inhibitor (R,R)-59 through stepwise structure-guided optimization. showed KD value 0.088±0.045...
BACKGROUND Liver cancer has a high incidence and mortality worldwide, especially in China. Herein, we investigated the therapeutic effect mechanism of tetrahydrocurcumin against hepatocellular carcinoma (HCC), with focus on phosphoinositide 3-kinases (PI3K)/AKT signaling pathway. AIM To investigate effects HCC cell lines HepG2 Huh7. METHODS Using Metascape, analyzed potential targets HCC. Molecular docking validation was performed using SYBYL2.0. Cell Counting Kit-8, wound healing, transwell...
Peptide-based coacervates are crucial for drug delivery due to their biocompatibility, versatility, high loading capacity, and cell penetration rates; however, stability mechanism phase behavior not fully understood. Additionally, although Martini is one of the most famous force fields capable describing coacervate formation with molecular details, a comprehensive benchmark its accuracy has been conducted. This research utilized 3.0 field machine learning algorithms explore representative...
Abstract In this paper, density functional theory (DFT) was performed to study the adsorption properties of ornidazole on anatase TiO 2 (101) and (001) crystal facets under vacuum, neutral acid-base conditions. We calculated structure ornidaozle surface, optimal sites, energy, states, electronic Milliken atomic charge different The results show that when N(3) atom imidazole ring is adsorbed Ti(5) atom, largest energy most stable configuration could be achieved. According analysis...
By meticulously managing the sequence of ingredient additions in complex coacervate, encapsulation efficiency for various proteins can be significantly enhanced.
Thrombocytopenia caused by long-term radiotherapy and chemotherapy exists in cancer treatment. Previous research demonstrates that 5-Hydroxtrayptamine (5-HT) its receptors induce the formation of megakaryocytes (MKs) platelets. However, relationships between 5-HT1A receptor (5-HTR1A) MKs is unclear so far. We screened investigated mechanism vilazodone as a 5-HTR1A partial agonist promoting MK differentiation evaluated therapeutic effect thrombocytopenia. employed drug screening model based...
Nonaromatic and nonconjugated fluorescent materials have garnered increasing attention in recent years. However, most non-classical chromophores are derived from electro-rich nitrogen oxygen atoms, which suffer short emission wavelengths, low efficiency, limited responsiveness, obscure luminescence mechanisms. Here we present an mechanism bioactive polycysteine, aliphatic polymer that displays polymerization- aggregation-induced emission, high quantum yield, multicolor properties. We show...
Background: Severe pneumonia is the predominant cause for acute respiratory distress syndrome (ARDS). Identification of ARDS from patients with severe remains a significant clinical problem due to overlap presentations and symptoms. Early recognition risks great value. Methods: From April 2014 December 2015, at admission were retrieved hospital database, which developed within 7 days further identified. We compared demographic characteristics between without development, followed by analysis...
In China, many deer species are threatened and their wild populations decreasing. this study, a segment of mitochondrial cytochrome oxidase subunit I (COI) was used as DNA barcode to identify Cervidae species. COI sequences 30 individuals from nine were determined. Together with 148 BOLD Genbank, total 178 21 the family analyzed. The results showed that all had unique sequences, there no sharing among them. mean K2P distances within species, genus, 1.3%, 3.4%, 8.9%, respectively....
Cisplatin is a frequently used and effective chemotherapy drug in clinical practice, but severe side effects limit its use, among which nephrotoxicity considered the most serious prolonged damage to body. Astragalus membranaceus (AM) well-known herbal medicine, modern pharmacological studies have confirmed antioxidant, immunomodulatory, antiapoptotic effects. Clinical shown that AM active components can attenuate cisplatin-induced kidney damage, molecular mechanism has not been fully...
Drug-induced immune thrombocytopenia (DITP) often occurs in patients receiving many drug treatments simultaneously. However, clinicians usually fail to accurately distinguish which drugs can be plausible culprits. Despite significant advances laboratory-based DITP testing, vitro experimental assays have been expensive and, certain cases, cannot provide a timely diagnosis patients. To address these shortcomings, this paper proposes an efficient machine learning-based method for toxicity...