A5101713041- Viral Infections and Vectors
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Viral Infections and Outbreaks Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Respiratory viral infections research
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Fire effects on ecosystems
- Pneumonia and Respiratory Infections
- Vector-Borne Animal Diseases
- Pediatric health and respiratory diseases
- Image Enhancement Techniques
- Immune Cell Function and Interaction
- Bacterial Infections and Vaccines
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hepatitis Viruses Studies and Epidemiology
- Herpesvirus Infections and Treatments
- Respiratory and Cough-Related Research
- Thermal Regulation in Medicine
- Influenza Virus Research Studies
- Long-Term Effects of COVID-19
- Virology and Viral Diseases
- Travel-related health issues
Southwest Jiaotong University
2025
Institute of Microbiology
2020-2022
Army Medical University
2022
Children's Hospital of Capital Institute of Pediatrics
2020
West China Medical Center of Sichuan University
1999
Nationwide prospective surveillance of all-age patients with acute respiratory infections was conducted in China between 2009‒2019. Here we report the etiological and epidemiological features 231,107 eligible enrolled this analysis. Children <5 years old school-age children have highest viral positivity rate (46.9%) bacterial (30.9%). Influenza virus, syncytial virus human rhinovirus are three leading pathogens proportions 28.5%, 16.8% 16.7%, Streptococcus pneumoniae, Mycoplasma pneumoniae...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease high fatality. Poor prognosis of SFTS has been associated dysregulated host immunity; however, the immune patterns pathophysiology involving exacerbation remain unclear. Here, we show that single-cell landscape peripheral responses reprogrammed in and characterized by monocyte shift to intermediate type along complement activation, perturbation plasmablast composition, highly exhausted T cells, all...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease high mortality, however no effective therapy available.The effect of favipiravir (FPV) in treating SFTS was evaluated by integrated analysis on data collected from a single-arm study (n=428), surveillance (n=2350) and published randomized controlled trial (n=145). A 1:1 propensity score matching performed to include 780 patients: 390 received FPV supportive only. Case fatality rates (CFRs), clinical...
The frequent movement of population between countries brings an increasing number travel-related infections. This study aims to define the spectrum and dynamics imported infections observed from international travel in Chinese mainland.Sick travellers were screened by inbound sentinel surveillance post-travel clinic visits 2014 18. classified as respiratory, gastrointestinal, vector-borne, blood/sexually transmitted mucocutaneous. analysed variables included place origin (Chinese or foreign)...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease a high case fatality rate. Key gaps remained as to the assessment of clinical picture in fatal cases.A retrospective study was performed on 496 patients SFTS. The dynamic pattern manifestations and laboratory indicators were delineated.The mean age cases 69.0 years (standard deviation: 9.3), 52.8% male. median course from onset death 11 (interquartile range: 10-13) days. A total (neutrophil %,...
Background: Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne disease high mortality. However, detailed analysis lacking to explore the complex effect of sex age or comorbidities. Methods: A retrospective cohort study was performed among 2,938 SFTS patients entered during 2011-2020 in Xinyang, China. The case fatality rate (CFR) estimated for their association sex, age, and comorbidities by an interactive way. difference immune response between explored dependent Results: An...
To explore the development of central nervous system (CNS) symptoms and clinical application in predicting outcomes SARS-COV-2 patients. A retrospective cohort study was performed on hospitalized patients with recruited from four hospitals Hubei Province, China 18 January to 10 March 2020. The CNS were determined. Data regarding laboratory tests collected medical records. Of 1268 studied, 162 (12.8%) had symptoms, manifested as unconsciousness (71, 5.6%), coma (69, 5.4%), dysphoria (50,...
Objective: To investigate the spectrum of pathogenic agents in pediatric patients with acute respiratory infections (ARI) during outbreak coronavirus infectious diseases 2019 (COVID-19). Methods: Three groups children were enrolled into prospective study January 20 to February 20, 2020 from Capital Institute Pediatrics, including exposed group ARI and epidemiological history associated COVID-19 whom both pharyngeal nasopharyngeal swabs collected, without screening for hospital admission,...
Human parechoviruses (HPeVs) are important causes of infection in children. However, without a comprehensive and persistent surveillance, the epidemiology clinical features HPeV remain ambiguous. We performed hospital-based surveillance study among three groups pediatric patients with acute respiratory (Group 1), diarrhea 2), hand, foot mouth disease 3) Chongqing, China, from 2009 to 2015. Among 10,212 tested patients, 707 (6.92%) were positive for HPeV, rates differing significantly 1,...