A5042513330- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Fire effects on ecosystems
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Influenza Virus Research Studies
- Fatty Acid Research and Health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Parvovirus B19 Infection Studies
- Advanced Battery Materials and Technologies
- Thermal Regulation in Medicine
- Mast cells and histamine
- Advanced battery technologies research
- Antioxidant Activity and Oxidative Stress
- Nutrition and Health in Aging
- Arsenic contamination and mitigation
- Respiratory viral infections research
- Physical Activity and Health
- Effects and risks of endocrine disrupting chemicals
- Animal Disease Management and Epidemiology
- COVID-19 Clinical Research Studies
- Vitamin C and Antioxidants Research
- Viral gastroenteritis research and epidemiology
- Autoimmune and Inflammatory Disorders Research
- Obesity and Health Practices
Academy of Military Medical Sciences
2024-2025
Shandong First Medical University
2024-2025
Academy of Medical Sciences
2025
Institute of Microbiology
2022-2024
Shandong Academy of Sciences
2022
Qilu University of Technology
2022
Qingdao University
2020-2021
A four-year-old boy developed recurrent fever and severe pneumonia in April, 2022. High-throughput sequencing revealed a reassortant avian influenza A-H3N8 virus (A/Henan/ZMD-22-2/2022(H3N8) with avian-origin HA NA genes. The six internal genes were acquired from Eurasian lineage H9N2 viruses. Molecular substitutions analysis the haemagglutin retained avian-like receptor binding specificity but that PB2 possessed sequence changes (E627K) associated increased virulence transmissibility...
In June 2019, a patient presented with persistent fever and multiple organ dysfunction after tick bite at wetland park in Inner Mongolia. Next-generation sequencing this revealed an infection previously unknown orthonairovirus, which we designated Wetland virus (WELV).
Highlights•Tocilizumab therapy can reduce the fatality for severe SFTS patients.•A combined of tocilizumab plus corticosteroids was recommended SFTS.•Patients treated with did not experience more serious coinfections.SummaryBackgroundSevere fever thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic high rates. The blockade pro-inflammatory cytokines presents a promising therapeutic strategy.MethodsWe conducted randomized clinical trial at 154th hospital, Xinyang, Henan Province....
Dietary factors play an important role in the development of depressive symptoms. Carotenoids have effective antioxidant and anti-inflammatory effects, but few studies explored associations between dietary carotenoid intake symptoms.To evaluate association risk symptoms adults from United States.This cross-sectional study included adult participants National Health Nutrition Examination Survey 2009-2016. Depressive were assessed using Patients' Questionnaire-9. Intake carotenoids was...
To determine whether glucocorticoids can improve clinical outcomes of severe fever with thrombocytopenia syndrome (SFTS) patients, and how to identify patients who may benefit from the treatment.A retrospective study was performed include confirmed SFTS designated hospitals. The effect in reducing case fatality rate (CFR) improving recovery evaluated by multivariate logistic regression models.A total 2478 eligible were analyzed, whom 331 received glucocorticoids. An integrated parameter...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease a high fatality rate. The clinical diagnosis criteria mainly rely on white blood cell (WBC) and platelet (PLT), which, however, are of limited usage in identifying atypical SFTS. A multicenter study was performed two hospitals from 2011 to 2023. SFTS patients were categorized as or typical based the criteria. Clinical progress outcomes compared between groups. total 2876 laboratory-confirmed included this...
ABSTRACT Viral infections disrupt glucose metabolism; however, their impact on disease prognosis in highly pathogenic viruses remains largely unknown. There is an additional need to investigate the antiviral mechanisms of glucose-lowering therapeutics. Here, our multicenter clinical study shows that hyperglycemia and pre-existing diabetes are independent risk factors for mortality patients infected with severe fever thrombocytopenia syndrome virus (SFTSV), emerging bunyavirus. SFTSV...
The relationship between ω-3 and ω-6 fatty acids consumption sleep disorders or duration are controversial. Therefore, we used the data of National Health Nutrition Examination Survey 2007–2016 in this cross-sectional study to explore their relationships. was assessed using two 24 h dietary recall interviews. Sleep were based on self-reported data. Logistic regression models restricted cubic spline analyses used. Compared with tertile one, odds ratios (ORs) 95% confidence intervals (CIs) for...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease a high case fatality rate. Few studies have been performed on bacterial or fungal coinfections the effect of antibiotic therapy. A retrospective, observational study was to assess prevalence and in patients hospitalized for SFTSV infection. The most commonly involved microorganisms antimicrobial therapy were determined by site source total 1201 infection included; 359 (29.9%) had microbiologically confirmed...
Abstract This study is performed to figure out how the presence of diabetes affects infection, progression and prognosis 2019 novel coronavirus disease (COVID-19), effective therapy that can treat diabetes-complicated patients with COVID-19. A multicentre was in four hospitals. COVID-19 mellitus (DM) or hyperglycaemia were compared those without these conditions matched by propensity score matching for their clinical progress outcome. Totally, 2444 confirmed recruited, from whom 336 had DM....
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease a high case fatality rate. Key gaps remained as to the assessment of clinical picture in fatal cases.A retrospective study was performed on 496 patients SFTS. The dynamic pattern manifestations and laboratory indicators were delineated.The mean age cases 69.0 years (standard deviation: 9.3), 52.8% male. median course from onset death 11 (interquartile range: 10-13) days. A total (neutrophil %,...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease increasing incidence and geographic extent. The extent to which global climate change affects the of SFTS remains obscure. We use integrated multi-model, multi-scenario framework assess impact on in China. spatial distribution habitat suitability for tick Haemaphysalis longicornis was predicted by applying a boosted regression tree model under four alternative scenarios (RCP2.6, RCP4.5, RCP6.0, RCP8.5)...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease a high fatality rate. How the glucose level might affect clinical outcome remains obscure.A multicenter study was performed in 2 hospitals from 2011 to 2021. Patients SFTS and acute hyperglycemia (admission fasting plasma [FPG] ≥7 mmol/L), postadmission FPG <7 mmol/L but after admission), euglycemia (FPG throughout hospitalization) were compared for their progress outcomes.A total of 3225 patients included...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic acquired by tick bites. Whether mast cells (MCs), the body's first line of defense against pathogens, might influence immunity or pathogenesis during SFTS virus (SFTSV) infection remained unknown. Here, we found that SFTSV can cause MC and degranulation, resulting in release vasoactive mediators, chymase, tryptase, which directly act on endothelial cells, break tight junctions threaten integrity microvascular...
Abstract The impact of Borrelia miyamotoi on human health, facilitated by the expanding geographical distribution and increasing population Ixodes ticks, remains obscure in context global climate change. We employed multiple models to evaluate effect change risk B. worldwide across various scenarios. habitat suitability index four primary vector tick species for , including persulcatus ricinus, pacificus scapularis was projected using a boosted regression tree model, considering shared...
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic acquired by tick bites. Whether mast cells (MCs), the body’s first line of defense against pathogens, might influence immunity or pathogenesis during SFTS virus (SFTSV) infection remained unknown.Methods: MCs were infected SFTSV and its response to was assessed in vitro vivo . MC-specific proteases locally injected into mouse footpads back skin investigate effect on endothelial vascular damage...
Abstract A four-year-old boy developed recurrent fever and severe pneumonia in April, 2022. High-throughput sequencing on his bronchoalveolar lavage fluid revealed a novel reassortant avian influenza A-H3N8 virus (A/Henan/ZMD-22-2/2022(H3N8). Both HA NA genes of the were origin, with gene most closely related to H3N2 H3N8 viruses detected ducks Guangdong Province, wild bird USA Japan. The six internal acquired from Eurasian lineage H9N2 viruses. Molecular substitutions analysis haemagglutin...