A5107953153- Immune cells in cancer
- Perovskite Materials and Applications
- Immune Response and Inflammation
- Migraine and Headache Studies
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Battery Materials and Technologies
- Nonlinear Photonic Systems
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Advanced battery technologies research
- Immunotherapy and Immune Responses
- Ophthalmology and Eye Disorders
- Lung Cancer Diagnosis and Treatment
- Dermatology and Skin Diseases
- Advancements in Battery Materials
- RNA Interference and Gene Delivery
- Atherosclerosis and Cardiovascular Diseases
- Extracellular vesicles in disease
- Medical Imaging Techniques and Applications
- Organic Light-Emitting Diodes Research
- Vestibular and auditory disorders
- Hearing Loss and Rehabilitation
- Olfactory and Sensory Function Studies
- Psoriasis: Treatment and Pathogenesis
- Nonlinear Waves and Solitons
Central South University
2012-2025
Ministry of Education
2025
Peking University
2012-2025
General Hospital of Shenyang Military Region
2025
Huazhong University of Science and Technology
2023-2025
Peking University Cancer Hospital
2024-2025
National Medical Products Administration
2024-2025
Chengdu University of Traditional Chinese Medicine
2024-2025
Kuaishou (China)
2024
Hebei University of Engineering
2008-2024
In June 2019, a patient presented with persistent fever and multiple organ dysfunction after tick bite at wetland park in Inner Mongolia. Next-generation sequencing this revealed an infection previously unknown orthonairovirus, which we designated Wetland virus (WELV).
Lipopolysaccharide (LPS) from Helicobacter pylori (HP) plays an important role in gastric cancer occurrence and development. Toll-like receptor 4 (TLR4) myeloid differential protein-2 (MD-2) are also reported to be involved cell proliferation invasion. CXC chemokine 7 (CXCR7), a second for CXCL12, has been detected multiple types of tumor tissues. Nevertheless, the biological function regulation CXCR7 its relationship with TLR4 MD-2 not completely understood therefore warrant further...
An association between carcinogenesis and inflammation has long been appreciated. Chemically induced colitis-associated cancer (CAC) is a classical mouse model for investigating 'inflammation-cancer link' in the intestine. Diverse mechanisms behind this non-resolving have reported before, most of them were emphasized on key genes, cytokines, signal transduction abnormality based prior knowledge. In study, we dynamically globally dissect alteration pathways development from colitis to...
Abstract Background Metastatic cervical squamous cell carcinoma (CSCC) has poor prognosis and is recalcitrant to the current treatment strategies, which warrants necessity identify novel prognostic markers therapeutic targets. Given that CSCC a virus-induced malignancy, we hypothesized pattern recognition receptors (PRRs) involved in innate immune response likely play critical role tumor development. Methods A bioinformatics analysis, qPCR, IHC, immunofluorescence, WB were performed...
Abstract Objective To evaluate the potential utility of 18 F-FDG PET/CT to assess response neoadjuvant immunochemotherapy in patients with resectable NSCLC, and ability screen who may benefit from immunochemotherapy. Methods Fifty one NSCLC (stage IA–IIIB) were analyzed, received two-three cycles was carried out at baseline(scan-1) prior radical resection(scan-2). SULmax, SULpeak, MTV, TLG, T/N ratio, ΔSULmax%,ΔSULpeak%, ΔMTV%, ΔTLG%,ΔT/N ratio% calculated. responses classified using...
Background/Aims: GLP-2 has been shown to exert anti-inflammatory effects, but the underlying molecular mechanisms remained undefined. As macrophages are important in development and maintenance of inflammation, we investigated whether exogenous modulates expression pro-inflammatory proteins LPS stimulated murine peritoneal macrophages. Methods: Macrophages were pretreated with various concentrations for 1 h then LPS. The effects on enzymes (iNOS COX-2), cytokines (TNF-a, IL-1ß IL-6) analysed...
Abstract Backgound Although Myeloid-derived suppressor cells (MDSCs) have a prominent ability to suppress the immune responses of T lymphocytes and propel tumor escape, lack profound systemic immunesuppression in tumor-bearing mice patients. The underlying mechanism these remains unclear. Methods For this purpose, renal cancer-derived exosomes (RDEs) were first labeled with PKH67 been observed internalization by MDSCs. Flow cytometry analysis showed proportion activity change MDSCs spleen...
This article reports a case of rare pulmonary metastases arising from an ovarian granulosa cell tumor using 18F-NOTA-FAPI-04 PET/CT. We discussed patient who was diagnosed with (stage IA) after surgery 15 years ago and developed metastases. The metastatic lesions solid (or) cystic components displayed variable (none to mild) fluorodeoxyglucose (FDG) avidity significantly higher uptake FAPI. highlighted the utility PET/CT, suggesting that it may serve as promising novel tool for diagnosis...
The performance of zinc-ion batteries (ZIBs) is often hindered by issues such as dendrite formation, hydrogen evolution, and limited cycling stability. 1,3-Dihydroxyacetone (DHA) not only stabilizes the anode modulating anode/electrolyte interface (AEI) but also enhances electrochemical battery through its spontaneous reversible keto-enol tautomerization, reducing concentration gradient on surface. Using a combination DFT calculations experimental characterization, regulation hydrated Zn2+...
The gradual increase in ultraviolet B (UVB) health hazards to human skin, coupled with the irritation associated existing sunscreen products, underscores critical need for development of natural sunscreens combat UVB-induced photoaging. Chuanxiong oil (CXO) and hyaluronic acid (HA) possess excellent antioxidant anti-apoptotic properties, which are closely linked mechanisms In this study, a composite nano-system (HA-CXO-Lip) comprising chuanxiong was initially fabricated. Subsequently, both...
ABSTRACT Exposure of the lungs to high O2 levels, can lead a noninfectious lung damage known as hyperoxia‐induced injury (HILI). Melatonin stimulation enhance efficacy stem cells in some diseases. This study aims investigate mechanism exosomes secreted by mesenchymal (MSCs) stimulated melatonin HILI. The MSCs‐derived were isolated and identified after with melatonin, neonatal rat model HILI was constructed. After injection related lentiviruses, ratio wet dry calculated evaluate pulmonary...
This study examined: (1) the value of using statistical metric, kurtosis [β(t)], along with an energy metric to determine hazard hearing from high level industrial noise environments, and (2) accuracy International Standard Organization (ISO-1999:1990) model for median noise-induced permanent threshold shift (NIPTS) estimates actual recent epidemiological data obtained on 240 highly screened workers exposed high-level in China. A cross-sectional approach was used this study. Shift-long...
Abstract Lower selenium levels are observed in Alzheimer’s disease (AD) brains, while supplementation shows multiple benefits. Selenoprotein W (SELENOW) is sensitive to changes and binds tau, reducing tau accumulation. However, whether restoration of SELENOW has any protective effect AD models its underlying mechanism remain unknown. Here, we confirm the association between downregulation pathology, revealing SELENOW’s role promoting degradation through ubiquitin‒proteasome system. competes...