A5101887952- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Natural product bioactivities and synthesis
- Peptidase Inhibition and Analysis
- ATP Synthase and ATPases Research
- Signaling Pathways in Disease
- Microtubule and mitosis dynamics
- Ginseng Biological Effects and Applications
- Ubiquitin and proteasome pathways
- Genomics, phytochemicals, and oxidative stress
- Cancer therapeutics and mechanisms
- Cancer, Hypoxia, and Metabolism
- Sphingolipid Metabolism and Signaling
- Extracellular vesicles in disease
- Nitric Oxide and Endothelin Effects
- RNA Research and Splicing
- Pharmacogenetics and Drug Metabolism
- Phytochemical compounds biological activities
- Fungal and yeast genetics research
- Influenza Virus Research Studies
Tianjin Medical University General Hospital
2025
Jinan University
2015-2024
Nanjing University of Chinese Medicine
2023
Jiangsu Provincial Academy of Traditional Chinese Medicine
2023
Guangzhou University of Chinese Medicine
2021
The Affiliated Yongchuan Hospital of Chongqing Medical University
2019
Chongqing Medical University
2019
Guangdong Pharmaceutical University
2017
Guangdong Provincial Hospital of Traditional Chinese Medicine
2012
Abstract Betulinic acid (BA) and its derivatives are a class of high-profile drug candidates, but their anticancer effects on resistant cancer have rarely been reported. Although few studies indicated mitophagy is related with resistance, role in different types agents treatment remains largely unclear. Here, we find that B5G1, new derivative BA, induces cell death multidrug cells HepG2/ADM MCF-7/ADR through mitochondrial-apoptosis pathway. B5G1 also triggers independent Atg5/Beclin 1....
Abstract While searching for natural anti-hepatocellular carcinoma (HCC) components in Ailanthus altissima , we discovered that ailanthone had potent antineoplastic activity against HCC. However, the molecular mechanisms underlying antitumor effect of on HCC have not been examined. In this study, and were evaluated vitro vivo . Mechanistic studies showed induced G 0 /G 1 -phase cell cycle arrest, as indicated by decreased expression cyclins CDKs increased p21 p27. Our results demonstrated...
Abstract GINS1 regulates DNA replication in the initiation and elongation phases plays an important role progression of various malignant tumors. However, hepatocellular carcinoma (HCC) remains largely unclear. In this study, we investigated underlying mechanisms contributing to HCC metastasis. We found that was significantly upregulated tissues cell lines, especially with vascular invasion lines highly metastatic properties. Additionally, high expression positively correlated progressive...
Epithelial-mesenchymal transition (EMT) plays an important role in prostate cancer (PCa) metastasis; thus, developing EMT inhibitors may be a feasible treatment for metastatic PCa. Here, we discovered that arenobufagin and four other bufadienolides suppressed PC3 cell EMT. These compounds modulated marker expression with elevating E-cadherin reducing ZEB1, vimentin slug expression, attenuated the migration invasion of cells. Among these five compounds, exhibited most potent activity. We...
Abstract Background M2-polarized tumor-associated macrophages (M2-TAMs) have been shown to correlate with the progression of various cancers, including intrahepatic cholangiocarcinoma (ICC). However, interactions and mechanism between M2 ICC are not completely clear. We aimed clarify whether promote malignancy its mechanism. Methods Two progressive murine models were used evaluate alterations in different macrophage populations phenotypes. Furthermore, we assessed infiltration 48 human 15...
Abstract Epidermal growth factor receptor (EGFR) activation plays a pivotal role in EGFR-driven non-small cell lung cancer (NSCLC) and is considered as key target of molecular targeted therapy. EGFR tyrosine kinase inhibitors (TKIs) have been canonically used NSCLC treatment. However, prevalent innate acquired resistances kinase-independent pro-survival properties limit the clinical efficacy TKIs. Therefore, discovery novel degraders promising approach towards improving therapeutic...
Chemotherapy is one of the most common therapeutic option for metastatic tumors and hematological malignancies. ABCB1-mediated multidrug resistance major obstacle chemotherapy. Natural products with diversified structures are ideal source ABCB1 modulators. Ganoderenic acid B, a lanostane-type triterpene isolated from Ganoderma lucidum, exhibited potent reversal effect on HepG2/ADM cells to doxorubicin, vincristine paclitaxel. Similarly, ganoderenic B could also significantly reverse...
BACKGROUND AND AIMS Myofibroblasts play a pivotal role in the development and progression of HCC. Here, we aimed to explore mechanism myofibroblast Musashi RNA binding protein 2 (MSI2) HCC progression. APPROACH RESULTS Myofibroblast infiltration collagen deposition were detected assessed tissues from 117 patients with Transgenic mice ( Msi2ΔCol1a1 ) floxed Msi2 allele type I alpha 1 chain Col1a1 )–ligand inducible Cre recombinases CreER constructed generate myofibroblast‐specific knockout...
Elevated production of reactive oxygen species (ROS) and an altered redox state have frequently been observed in hepatocellular carcinoma (HCC); therefore, selective killing HCC cells by chemotherapeutic agents that stimulate ROS generation or impair antioxidant systems may be a feasible approach chemotherapy. Recently, betulinic acid its derivatives attracted attention because they showed anti-cancer effects via ROS- mitochondria-related mechanism. However, the source overproduction role...
Abstract Elongation factor Tu GTP binding domain containing 2 (EFTUD2), a spliceosomal GTPase, plays pivotal role in multiple organ development and innate immune. It has been reported that EFTUD2 is new host with activity against HCV infection. However, the of solid tumors, including hepatocellular carcinoma (HCC), remains unexplored. In this study, we investigated molecular function HCC. Data from The Cancer Genome Atlas (TCGA) indicated an upregulation HCC tissues compared to nontumor...
Abstract Cholangiocarcinoma (CCA) is a highly heterogeneous and metastatic malignancy with poor prognosis even after curative hepatectomy. Studies exploring its pathogenesis identifying effective therapeutic targets are urgently needed. In this study, we found that TANK-binding kinase 1 (TBK1), serine/threonine-protein kinase, showed dynamic increase during the different stages of murine spontaneous CCA carcinogenesis (hyperplasia, dysplasia, CCA). TBK1 was upregulated in human tissues,...
Sarcandra glabra , as a type of “antipyretic-detoxicate drugs”, has always been widely used in traditional Chinese medicine (TCM). The extract (SGE) is applied frequently anti-inflammatory and anti-infectious drug folk medicine. However, relative experiment data supporting this effective clinical consequence was limited. In order to mimic the physiological conditions susceptible population, we employed restraint stress mouse model investigate effect SGE against influenza. Mice were infected...
The overexpression of ATP-binding cassette (ABC) transporters is the main cause cancer multidrug resistance (MDR), which leads to chemotherapy failure. Uncaria alkaloids are major active components isolated from uncaria, a common Chinese herbal medicine. In this study, MDR-reversal activities uncaria alkaloids, including rhynchophylline, isorhynchophylline, corynoxeine, isocorynoxeine (Icory), hirsutine and hirsuteine, were screened; they all exhibited potent reversal efficacy when combined...
Background/Aims: Hepatocellular carcinoma (HCC) is the most common type of liver cancer. At present, only sorafenib approved to treat HCC. In this study, we found that a 23-hydroxybetulinic acid derivative, B4G2, exhibited potent antiproliferative activity in HCC cell lines. Methods: We used four lines (HepG2, HepG2/ADM, Hep3B and Bel-7402) evaluate anti-tumour explore underlying mechanisms by which B4G2 induces apoptosis. Results: Among these lines, HepG2 showed highest sensitivity B4G2....
Two new flavonoids, calquiquelignan M (1), N (2), along with nine known compounds (3-11), were isolated from the nuts of Areca catechu (Palmae). The structures, including absolute configurations, established by a combination spectroscopic data and electronic circular dichroism (ECD) calculation. identified comparing their reported in literature. flavonoids (1-8) evaluated for cytotoxicity activities against three human cancer cell lines. Compounds 1 2 exhibited moderate cytotoxic activity...
Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone that plays vital role in the signal transduction of cancers. Hsp90 inhibitors are able to inhibit or complex and co-chaperones resulting degradation Hsp90-dependent client proteins through ubiquitination-proteasome pathway, thereby leading growth inhibition tumor cells. This review will briefly discuss structure biological function Hsp90, focus on summary recent progress development testing natural their different means...
It has been demonstrated that bufadienolides exert potent anti-cancer activity in various tumor types. However, the mechanisms underlie their properties remain unclear. Yes-associated protein, a key effector of Hippo signaling, functions as transcription coactivator, plays oncogenic and suppressor roles under different conditions. Here, we report arenobufagin (ABF), representative bufadienolide, induced breast cancer MCF-7 cells to undergo apoptosis, which occurred through JNK-mediated...