A5023825932- Peptidase Inhibition and Analysis
- Phagocytosis and Immune Regulation
- Ubiquitin and proteasome pathways
- Angiogenesis and VEGF in Cancer
- Protease and Inhibitor Mechanisms
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Cancer Mechanisms and Therapy
- Hormonal Regulation and Hypertension
- Silk-based biomaterials and applications
- Cancer Research and Treatments
- Cancer-related gene regulation
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Hippo pathway signaling and YAP/TAZ
- Ginseng Biological Effects and Applications
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- TGF-β signaling in diseases
Jinan University
2016-2025
University of Washington
2023-2024
First Affiliated Hospital of Jinan University
2023
Chongqing Medical University
2023
Guangdong Pharmaceutical University
2017-2019
Wuhan Children's Hospital
2017
Huazhong University of Science and Technology
2017
Southwest University
2011-2014
State Key Laboratory of Silkworm Genomic Biology
2012-2014
Chinese Academy of Sciences
2006
Ischemic stroke is one of the most lethal and highly disabling diseases that seriously affects human health quality life. A therapeutic angiogenic strategy has been proposed to alleviate ischemia-induced injury by promoting angiogenesis improving cerebrovascular function in ischemic regions. The insulin-like growth factor 1 (IGF-1)/insulin-like receptor (IGF1R) axis crucial for cerebral neurogenesis. However, effective drugs prevent inducing via activation IGF1R pathway are lacking. Here, we...
Vessel co-option has been demonstrated to mediate colorectal cancer liver metastasis (CRCLM) resistance antiangiogenic therapy. The current mechanisms underlying vessel have mainly focused on "hijacker" tumor cells, whereas the function of "hijackee" sinusoidal blood vessels not explored. Here, we found that occurrence in bevacizumab-resistant CRCLM xenografts was associated with increased expression fibroblast activation protein α (FAPα) co-opted hepatic stellate cells (HSCs), which...
Blood vessels in the tumor periphery have high pericyte coverage and are resistant to vascular disrupting agents (VDAs). VDA treatment resistance leads a viable peripheral rim that contributes failure disease recurrence. Here, we provide evidence support hypothesis shifting target of VDAs from vessel endothelial cells pericytes disrupts rim, circumventing resistance. Through chemical engineering, developed Z-GP-DAVLBH (from tubulin-binding desacetylvinblastine monohydrazide [DAVLBH]) as...
Objective Haematogenous dissemination is a prevalent route of colorectal cancer (CRC) metastasis. However, as the gatekeeper vessels, role tumour pericytes (TPCs) in haematogenous metastasis remains largely unknown. Here, we aimed to investigate heterogeneity TPCs and their effects on CRC Design were isolated from patients with or without liver metastases analysed by single-cell RNA sequencing (scRNA-seq). Clinical specimens collected analyse association between molecular profiling...
Epithelial-mesenchymal transition (EMT) plays an important role in prostate cancer (PCa) metastasis; thus, developing EMT inhibitors may be a feasible treatment for metastatic PCa. Here, we discovered that arenobufagin and four other bufadienolides suppressed PC3 cell EMT. These compounds modulated marker expression with elevating E-cadherin reducing ZEB1, vimentin slug expression, attenuated the migration invasion of cells. Among these five compounds, exhibited most potent activity. We...
Bufadienolides are the major pharmacologic constituents of traditional Chinese medicine Chan'su, which is frequently used clinically for cancer treatment in China. Motivated by reducing or avoiding cardiac toxicity bufadienolides, we have designed, synthesized, and evaluated fibroblast activation protein α (FAPα) activated tripeptide arenobufagin prodrugs with purpose improving safety (a representative bufadienolide). Among these FAPα-activated prodrugs, 3f exhibited best hydrolytic...
Knee osteoarthritis (KOA) is associated with a high risk of sarcopenia. Both intra-articular injections (IAIs) and physical therapy (PT) exert benefits in KOA. This network meta-analysis (NMA) study aimed to identify comparative efficacy among the combined treatments (IAI+PT) patients Seven electronic databases were systematically searched from inception until January 2023 for randomized controlled trials (RCTs) reporting effects IAI+PT vs. IAI or PT alone All RCTs which had treatment arms...
Abstract Antiangiogenic tyrosine kinase inhibitors (AA‐TKIs) have become a promising therapeutic strategy for colorectal cancer (CRC). In clinical practice, significant proportion of patients temporarily discontinue AA‐TKI treatment due to recurrent toxicities, economic burden or acquired resistance. However, therapy withdrawal‐induced tumour revascularization frequently occurs, hampering the application AA‐TKIs. Here, this study demonstrates that perivascular cells mediate after withdrawal...
Osteosarcoma is a kind of bone tumor with highly proliferative and invasive properties, high incidence pulmonary metastasis poor prognosis. Chemotherapy the mainstay treatment for osteosarcoma. Currently, there are no molecular targeted drugs approved osteosarcoma treatment, particularly effective metastases. It has been reported that fibroblast activation protein alpha (FAPα) upregulated in critically associated progression metastasis, demonstrating FAPα-targeted agents might be promising...
Background Advanced or metastatic prostate cancer (PCa) is still an incurable malignancy with high lethality and a poor prognosis. Despite the remarkable success of immunotherapy against many types cancer, most patients PCa receive minimal benefit from current immunotherapeutic strategies, because immune cold tumor scarce T-cell infiltration in microenvironment. The aim this study was to develop effective approach for tumors. Methods therapeutic efficacy androgen deprivation therapy (ADT)...
Abstract Hematogenous metastasis is the main approach for colorectal cancer liver (CRCLM). However, as gatekeepers in tumor vessels, role of TPCs hematogenous remains largely unknown, which may be attributed to lack specific biomarkers TPC isolation. Here, microdissection combined with a pericyte medium‐based developed obtain from CRC patients. Proteomic analysis reveals that TRP channel‐associated factor 2 (TCAF2), partner protein transient receptor potential cation channel subfamily M...
Vessel co-option is responsible for tumor resistance to antiangiogenic therapies (AATs) in patients with colorectal cancer liver metastasis (CRCLM). However, the mechanisms underlying vessel remain largely unknown. Herein, we investigated roles of a novel lncRNA SYTL5-OT4 and Alanine-Serine-Cysteine Transporter 2 (ASCT2) co-option-mediated AAT resistance.SYTL5-OT4 was identified by RNA-sequencing verified RT-qPCR RNA fluorescence situ hybridization assays. The effects ASCT2 on cells were...
Osteoarthritis is associated with high risks of sarcopenia in older populations. Exercise interventions are promising treatments for musculoskeletal impairments knee osteoarthritis (KOA). The purpose this study was to identify the comparative effects exercise monotherapy and its adjunct on muscle volume serum inflammation individuals KOA. A literature search electronic databases comprehensively performed from study's inception until April 2024 relevant randomized controlled trials (RCTs)...
Metastatic BRAFV600E colorectal cancer (CRC) confers poor prognosis and represents a therapeutic bottleneck. To identify resistance mechanisms of the mitogen-activated protein kinase (MAPK) pathway in CRC, we perform genome-wide CRISPR-Cas9 screening discover that targeting glutathione peroxidase 4 (GPX4) overcomes to BRAF inhibitor (BRAFi) combined with or without epidermal growth factor receptor (EGFRi) CRC. Specifically, BRAFi ± EGFRi upregulates GPX4 expression, which antagonizes...
Growth arrest-specific protein 6 (Gas6) induces the activation of Axl receptor tyrosine kinase (Axl), which plays an important role in angiogenic processes, including proliferation, migration, invasion, tube formation and pericyte recruitment endothelial cells. The inhibition Gas6/Axl pathway has been demonstrated to be effective anti-angiogenic therapy. Luteolin, is a natural active flavonoid, reported possess effects. However, underlying mechanism luteolin anti-angiogenesis not fully...