A5054774625- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related Molecular Pathways
- RNA Interference and Gene Delivery
- Mycobacterium research and diagnosis
- Inflammatory mediators and NSAID effects
- Thyroid Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Galectins and Cancer Biology
- Radiopharmaceutical Chemistry and Applications
- Thyroid Disorders and Treatments
- Cancer Cells and Metastasis
- Bone health and treatments
- Cancer Research and Treatment
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
Xiangnan University
2020-2025
First Affiliated Hospital of Jinan University
2012-2020
The transformation of tumor cells from an epithelial to a mesenchymal-like phenotype, designated as epithelial-to-mesenchymal transition (EMT), represents key hallmark human cancer metastasis, including gastric (GC). However, large set non-coding RNAs have been studied for their functions that initiate or inhibit this phenotypic switch in GC by regulating oncogenes suppressors. In paper, we aimed identify lncRNA SND1-IT1, miR-124, and COL4A1 gene the context with specific focus on effects...
Metastatic BRAFV600E colorectal cancer (CRC) confers poor prognosis and represents a therapeutic bottleneck. To identify resistance mechanisms of the mitogen-activated protein kinase (MAPK) pathway in CRC, we perform genome-wide CRISPR-Cas9 screening discover that targeting glutathione peroxidase 4 (GPX4) overcomes to BRAF inhibitor (BRAFi) combined with or without epidermal growth factor receptor (EGFRi) CRC. Specifically, BRAFi ± EGFRi upregulates GPX4 expression, which antagonizes...
Collagen triple helix repeat containing-1 (CTHRC1) promotes tumor progression by regulating the immunosuppression of microenvironment. However, function CTHRC1 in gastric cancer (GC) and its relationship with tumor-infiltrating immune cells remains unclear.Data were downloaded from The Cancer Genome Atlas (TCGA) database. difference expression GC adjacent non-tumor tissues was analyzed R software verified online database Oncomine. A Kaplan-Meier survival analysis selected for evaluating...
Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) plays a crucial role in modulating extracellular matrix component and promoting tumor progression by changing adhesion, migration, other biological behaviors some cancers. However, its expression pattern, function, underlying mechanism pancreatic cancer remain largely unclear.In this study, set of bioinformatics tools were used to analyze the P4HA1 prognostic value cancer. In addition, through which promotes was explored constructing competing...
Zeste White 10 interactor (ZW10 interactor, ZWINT) is a centromeric complex required for mitotic spindle checkpoint. According to previous studies, it was overexpressed in people with recurrent tumors. However, the expression of ZWINT breast cancer has not been thoroughly studied. In addition, correlations prognosis remain unclear.In this study, different types tumors analyzed based on Oncomine database, and effect clinical evaluated by Kaplan-Meier plotter.In cancer, lung sarcoma, ovarian...
To evaluate the correlation between COX-2 overexpression and clinicopathological features of gastric cancer, thus providing theoretical basis for anti-COX-2 targeted therapy.The literature about expression cancer was searched in PubMed, Wangfang, VIP, CNKI from inception to September 2019, with "gastric cancer", "COX-2", "cyclooxygenase" as keywords. Stata 15.0 used analyze. Age, gender, differentiation, infiltration depth, lymph node metastasis, tumor size, TNM staging were analyzed by OR...
Background. Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide. Additionally, deletion of RAPGEF2 plays a critical role in CNV and related to immune microenvironment, whereas prognostic potential HCC patient needs be explored. Methods. We looked for genes using variety R programs. Then, LASSO Cox regression, we thoroughly evaluated integrated RAPGEF2-related from TCGA database. Meanwhile, utilizing ICGA databases, link between immunotherapy response was studied. In vivo,...
We aimed to identify the key differentially expressed genes (DEGs) associated with poor prognosis in gastric cancer (GC) and elucidate underlying molecular mechanisms order provide a therapeutic target for this disease.The DEGs common two datasets, GSE54129 GSE79973, were screened. GO KEGG enrichment analyses then performed these using DAVID's tool. STRING Cytoscope software also used analyze protein-protein interaction (PPI) networks of between datasets.A total 164 identified from GSE79973...
Overexpression of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in various tumor tissues and cell lines was found to promote proliferation, migration, invasion. However, the role MALAT1 gastric cancer (GC) is still unclear. We aimed investigate correlation between long-chain non-coding RNAs (lncRNAs), MALAT1, MicroRNAs (miRNA) vascular endothelial growth factor A (VEGFA) disclose underlying mechanism. The levels clinical features analyzed by bioinformatics data human...
Thyroid hormone is an important for regulating cell differentiation,growth and metabolism.Many studies have shown that thyroid can induce turmor angiogenesis after binding with the integrin ανβ3 receptor at surface.Tetraiodothyroacetic acid analogue of hormone,and inhibit tumor by inhibiting ανβ3.Studying role in promoting may provide a new approach molecular targeted therapy tumor. Key words: Thyroxine; Neoplasms; Targeted
Abstract Background: It has been reported that reduction of miR-126 can promote the progression gastric cancer (GC). However, regulation in GC is still unclear. This study aims to explore correlation between lncRNA MALAT1 and disclose underlying mechanisms. Methods: We analyzed levels clinical features by analysis bioinformatic data human samples. Then we down-regulate expression AGS cells examined characteristics cell proliferation, cycle, apoptosis, migration, invasion, effect on as well...