A5028283803- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Signaling Pathways in Disease
- Colorectal Cancer Treatments and Studies
- Tuberous Sclerosis Complex Research
- Ion Channels and Receptors
- Photodynamic Therapy Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Brain Metastases and Treatment
- Immune cells in cancer
- MRI in cancer diagnosis
- Digestive system and related health
- Barrier Structure and Function Studies
- Analytical Chemistry and Sensors
- Protease and Inhibitor Mechanisms
Jinan University
2023-2025
Xiangya Hospital Central South University
2024-2025
Central South University
2024-2025
Shanghai Jiao Tong University
2025
Renji Hospital
2025
Sun Yat-sen University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Abstract: Pericytes, also known as mural cells, are cells embedded between endothelial and the basement membrane of capillaries, where they orchestrate morphological functional homeostasis blood vessels. Within tumor microenvironment, pericytes interact closely with various cellular components, including stromal immune cells. Through these dynamic interactions, activated subsequently transform into tumor-associated (TPCs). The origin TPCs varies depending on tissue type, contributing to...
Abstract Hematogenous metastasis is the main approach for colorectal cancer liver (CRCLM). However, as gatekeepers in tumor vessels, role of TPCs hematogenous remains largely unknown, which may be attributed to lack specific biomarkers TPC isolation. Here, microdissection combined with a pericyte medium‐based developed obtain from CRC patients. Proteomic analysis reveals that TRP channel‐associated factor 2 (TCAF2), partner protein transient receptor potential cation channel subfamily M...
Abstract Selective nuclear export inhibitor selinexor (SEL) represents a promising therapeutic strategy for relapsed/refractory multiple myeloma (RRMM). But its mechanisms of action as well factors that influence responses have not been fully characterized yet. In this study we employed catTFRE proteomics technique to profile changes in abundance activated transcription (TFs)/co-factors (TCs) cells following SEL treatment. We found pharmacological inhibition exportin-1 (XPO1) by leads...
Abstract Background Intestinal fibrosis is a significant clinical challenge in inflammatory bowel diseases, but no effective anti-fibrotic therapy currently available. GCGR and GLP1R are both peptide hormone receptors involved energy metabolism of epithelial cells. However, their role intestinal the underlying mechanisms remain largely unexplored. Methods tissues from patients with Crohn’s Disease (CD) (n=20) were obtained. AAV9-Glp1r-shRNA, AAV9-Gcgr-shRNA or AAV9-NC-shRNA used to transfect...
Abstract Background Excessive pericyte coverage promotes tumor growth, and a downregulation may solve this dilemma. Due to the double-edged sword role of vascular pericytes in microenvironment (TME), indiscriminately decreasing by imatinib causes poor treatment outcomes. Here, we optimized use colorectal cancer (CRC) model high pericyte-coverage status, revealed value multiparametric magnetic resonance imaging (mpMRI) at 9.4T monitoring treatment-related changes TME. Methods CRC xenograft...
To assess the efficacy and safety of preoperative neoadjuvant everolimus in renal angiomyolipomas (AML) patients with or without Tuberous Sclerosis Complex (TSC).
Efficient delivery of photons to visceral organs is critical for the treatment deep‐seated tumors taking advantage photo theranostics. Optical fiber can be regarded as a direct and facile photon pathway targeting tumor lesion. However, current theranostic strategies rely on spatially separated optical fibers realize diagnosis therapy independently, resulting in low compactness, poor continuity medical process, incompatibility with technologies. Herein, an integrated fiber‐optic (iFOT) probe...
Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases risk of cancer recurrence and distant metastasis. The properties lymph node (LNM-CRC) cells are poorly understood, effective therapies still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha (FAP
e16519 Background: The combination of immune checkpoint inhibitor (ICI) and tyrosine kinase (TKI) has emerged as the standard first-line therapy for metastatic renal cell carcinoma (mRCC), however, limited clinical trials have investigated role ICI plus TKI in treatment non-clear (mnccRCC) its heterogeneity low incidence. Our study presents multiple center real-world data with optimal sample size so far to assess efficacy safety profile patients mnccRCC. Methods: We performed a retrospective...
113 Background: Over half of the patients with muscle-invasive bladder cancer (MIBC) do not benefit from neoadjuvant chemotherapy due to cisplatin intolerance or resistance and have a poor prognosis. Antibody-drug conjugates (ADCs) shown excellent clinical benefits in advanced MIBC recent years, but there is lack studies using ADCs as treatment. Methods: Patients were eligible for inclusion criteria included received RC48-ADC (disitamab vedotin) combined toripalimab (n=79) tislelizumab...