A5100766359- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Geoscience and Mining Technology
- Additive Manufacturing and 3D Printing Technologies
- Thermal properties of materials
- Additive Manufacturing Materials and Processes
- Radioactive element chemistry and processing
- Hydrocarbon exploration and reservoir analysis
- Bladder and Urothelial Cancer Treatments
- Cancer-related gene regulation
- Polymer Nanocomposites and Properties
- Epigenetics and DNA Methylation
- Geomechanics and Mining Engineering
- Thermal Radiation and Cooling Technologies
- Molecular Biology Techniques and Applications
- Carbon Nanotubes in Composites
- Endometrial and Cervical Cancer Treatments
- Immune cells in cancer
- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
- High Entropy Alloys Studies
Nanjing Medical University
2006-2025
Jiangsu Province Hospital
2018-2025
Inner Mongolia Agricultural University
2012-2025
Ministry of Agriculture and Rural Affairs
2022-2025
Qingdao University of Science and Technology
2017-2025
Xidian University
2014-2025
Central South University of Forestry and Technology
2023-2025
Xiangya Hospital Central South University
2021-2025
Central South University
2021-2025
Hunan Normal University
2016-2025
Chemotherapy resistance remains a barrier to improving the prognosis of epithelial ovarian cancer (EOC). ALKBH5 has recently been shown be one RNA N6-methyladenosine (m6A) demethyltransferases associated with various cancers, but its role in therapeutic unclear. This study aimed investigate AlkB homolog 5 (ALKBH5) cisplatin-resistant EOC.Functional assays were performed both vitro and vivo. sequencing (RNA-seq), m6A-modified immunoprecipitation (MeRIP-seq), chromatin immunoprecipitation,...
Background Bladder cancer (BLCA) is the most common malignancy of urinary tract. On other hand, disulfidptosis, a mechanism disulfide stress-induced cell death, closely associated with tumorigenesis and progression. Here, we investigated impact disulfidptosis-related genes (DRGs) on prognosis BLCA, identified various DRG clusters, developed risk model to assess patient prognosis, immunological profile, treatment response. Methods The expression mutational characteristics four DRGs were first...
Ovarian cancer (OC) is one of the most common and malignant gynecological malignancies in gynecology. On other hand, dysregulation copper metabolism (CM) closely associated with tumourigenesis progression. Here, we investigated impact genes (CMRGs) on prognosis OC, discovered various CM clusters, built a risk model to evaluate patient prognosis, immunological features, therapy response.15 CMRGs affecting OC patients were identified The Cancer Genome Atlas (TCGA). Consensus Clustering was...
Background Head and neck squamous cell carcinoma (HNSCC) is the most common head cancer highly aggressive heterogeneous, leading to variable prognosis immunotherapy outcomes. Circadian rhythm alterations in tumourigenesis are of equal importance genetic factors several biologic clock genes considered be prognostic biomarkers for various cancers. The aim this study was establish reliable markers based on genes, thus providing a new perspective assessing response patients with HNSCC. Methods...
Hepatocellular carcinoma (HCC) is a complex disease with poor outlook for patients in advanced stages. Immune cells play an important role the progression of HCC. The metabolism sphingolipids functions both tumor growth and immune infiltration. However, little research has focused on using sphingolipid factors to predict HCC prognosis. This study aimed identify key genes (SPGs) develop reliable prognostic model based these genes.The TCGA, GEO, ICGC datasets were grouped SPGs obtained from...
Abstract To improve response rate of monotherapy immune checkpoint blockade (ICB), it is necessary to find an emerging target in combination therapy. Through analyzing tumor microenvironment (TME)‐related indicators, validated that BCAT2 shapes a noninflamed TME bladder cancer. The outcomes multiomics indicate has inhibitory effect on cytotoxic lymphocyte recruitment by restraining activities proinflammatory cytokine/chemokine‐related pathways and T‐cell‐chemotaxis pathway. Immunoassays...
Municipal solid waste (MSW) is the derivative of urban development and it harmful to environment residents’ health. But with sustainable MSW management, can be applied as an important renewable energy. In order achieve necessary understand mechanism generation. Consumption patterns differ in various regions China, which make influencing factors have unique characteristics. To explore generation this study builds a global model based on panel data 30 Chinese provinces. Considering regional...
Endometrial cancer (EC) is one of the female malignant tumors. predominately affects post-menopausal women. Bioinformatics analysis has been widely applied to screen and analyze genes in linkage various types progression.Download gene expression profile from Gene Expression Omnibus (GEO). Calculate raw data according pre-processing procedures. We performed "limma" R language package DEGs between tissue samples normal uterus samples. Enrichment functions pathways was analyzed by using...
Most terrestrial plants form a root symbiosis with arbuscular mycorrhizal (AM) fungi, which receive fixed carbon from the plant and enhance plant's uptake of mineral nutrients. AM improves phosphorous nitrogen nutrition host plants; however, little is known about role in potassium (K+) nutrition. Here, we report that inoculation fungus Rhizophagus irregularis improved tomato (Solanum lycopersicum) growth K+ acquisition deficiency has negative effect on colonization. Based its homology to...
To parallelly compare the efficacy of neoadjuvant immunotherapy (tislelizumab), chemotherapy (gemcitabine and cisplatin), combination therapy (tislelizumab + GC) in patients with muscle-invasive bladder cancer (MIBC) explore predictors, we perform a multi-center, real-world cohort study that enrolls 253 treated treatments (combination therapy: 98, chemotherapy: 107, immunotherapy: 48) from 15 tertiary hospitals. We demonstrate achieves highest complete response rate pathological downstaging...
recently, many researches have concentrated on the relevance between N1-methyladenosine (m1A) methylation modifications and tumor progression prognosis. However, it remains unknown whether m1A modification has an effect in prognosis of ovarian cancer (OC) its immune infiltration.Based 10 modulators, we comprehensively assessed patterns 474 OC patients linked them to TME infiltration characteristics. m1Ascore computed with principal component analysis algorithm was applied quantify pattern...
Uterine corpus endometrial carcinoma (UCEC) is a malignant disease globally, and there no unified prognostic signature at present. In our study, two clusters were identified. Cluster 1 showed better prognosis higher infiltration level, such as tumor microenvironment (TME), mutation burden (TMB), immune checkpoint genes expression. Gene set enrichment analysis (GSEA) indicated that some tumor-related pathways immune-associated exposed. What more, six pyroptosis-related long noncoding RNAs...
This paper presents the first challenge on demosaicing of natural spectral images for snapshot hyperspectral imaging systems (HIS) which utilize a multi-spectral filer array (MSFA), i.e., recovery whole-scene information from spatially sub-sampled information. expands "ARAD_1K" data set to first-of-its-kind large-scale multispectral filter scenes containing 1,000 images. Challenge participants were required recover synthetically generated MSFA simulating capture by known calibrated mosaic...
Abstract Background Ciprofol is a recently developed, short-acting γ-aminobutyric acid receptor agonist sedative that more potent than propofol, but there have been few clinical studies of this agent to date. Here, we sought examine the safety and efficacy ciprofol use for induction general anesthesia in individuals undergoing gynecological surgery. Methods Women between ages 18 60 years (ASA physical status 1 or 2) who were scheduled undergo elective surgery under randomly assigned two...