A5000982571- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Neurobiology of Language and Bilingualism
- Autoimmune Neurological Disorders and Treatments
- Psychosomatic Disorders and Their Treatments
- Medical Imaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- RNA Interference and Gene Delivery
- S100 Proteins and Annexins
- Bone Tissue Engineering Materials
- Speech Recognition and Synthesis
- Neural and Behavioral Psychology Studies
- Genetics and Neurodevelopmental Disorders
- Paranormal Experiences and Beliefs
- Speech and Audio Processing
- Genetic Neurodegenerative Diseases
- Bone Metabolism and Diseases
- Peripheral Neuropathies and Disorders
- Advanced Image Fusion Techniques
- Academic Writing and Publishing
- Neurological diseases and metabolism
- Glycogen Storage Diseases and Myoclonus
- Biological Stains and Phytochemicals
- Bone and Dental Protein Studies
McGill University
2012-2025
Nanjing University of Chinese Medicine
2021-2024
Southeast University
2024
Montreal Neurological Institute and Hospital
2011-2023
Jiangyin People's Hospital
2023
Ningbo Medical Center Lihuili Hospital
2023
Ningbo University
2023
Jewish General Hospital
2017-2020
Massachusetts General Hospital
2015-2017
Harvard University
2015-2017
Previous postmortem studies have long demonstrated that neurofibrillary tangles made of hyperphosphorylated tau proteins are closely associated with Alzheimer disease clinical phenotype and neurodegeneration pattern. Validating these associations in vivo will lead to new diagnostic tools for better understanding its neurobiology.
Objectives To assess the association between sodium-glucose co-transporter-2 inhibitor (SGLT-2i) use and risk of incident dementia compared with dipeptidyl peptidase-4 inhibitors (DPP-4i) among individuals type 2 diabetes. Design A population-based retrospective cohort study. Setting The Clinical Practice Research Datalink (CPRD) Aurum database from UK. Participants Individuals diabetes, aged 40 years or older, newly prescribed SGLT-2i DPP-4i on after 2013–2021, registered in CPRD database....
This paper presents the first challenge on demosaicing of natural spectral images for snapshot hyperspectral imaging systems (HIS) which utilize a multi-spectral filer array (MSFA), i.e., recovery whole-scene information from spatially sub-sampled information. expands "ARAD_1K" data set to first-of-its-kind large-scale multispectral filter scenes containing 1,000 images. Challenge participants were required recover synthetically generated MSFA simulating capture by known calibrated mosaic...
Alzheimer’s disease (AD) has long been recognized as a heterogeneous illness, with common clinical presentation of progressive amnesia and less “atypical” presentations, including syndromes dominated by visual, aphasic, “frontal,” or apraxic symptoms. Our knowledge atypical phenotypes AD comes from clinicopathologic studies, but the growing use in vivo molecular biomarkers amyloid tau pathology, we are beginning to recognize that these may not be rare once thought. When clinician is...
Recent studies of political behavior suggest that voting decisions can be influenced substantially by “first-impression” social attributions based on physical appearance. Separate lines research have implicated the orbitofrontal cortex (OFC) in judgment traits one hand and economic decision-making other, making this region a plausible candidate for linking to decisions. Here, we asked whether OFC lesions humans disrupted ability judge candidates or affected how these judgments Seven patients...
Abstract: Large-scale intrinsic brain systems have been identified for exteroceptive senses (e.g., sight, hearing, touch). We introduce an analogous system representing sensations from within the body, called interoception, and demonstrate its relation to regulating peripheral in allostasis. Employing recently introduced Embodied Predictive Interoception Coding (EPIC) model, we used tract-tracing studies of macaque monkeys, followed by two functional magnetic resonance imaging samples ( N =...
Abstract Individual differences in arousal experience have been linked to resting-state salience network connectivity strength. In this study, we investigated how adding task-related skin conductance responses (SCR), a measure of sympathetic autonomic nervous system activity, can predict additional variance experience. Thirty-nine young adults rated their subjective emotionally evocative images while SCRs were measured. They also underwent separate fMRI scan. Greater SCR reactivity (an...
Acute lung injury (ALI) is a severe inflammatory syndrome, which was caused by diverse factors. The COVID-19 pandemic has resulted in higher mortality rate of these conditions. Currently, effective treatments are lacking. Although siRNA nucleotide-based drugs promising therapeutic approaches, their poor stability and inability to efficiently reach target cells limit clinical translation. This study identified peptide from known cell-penetrating peptides that can form an efficient...
Prefrontal cortex (PFC) has been implicated in the experience and regulation of emotional states. Emotional is a complex construct, encompassing range more specific processes. This exploratory study aimed to delineate which (if any) aspects rely critically on either ventromedial frontal (VMF) or lateral (LF) lobes. The affective individuals with damage these regions was surveyed detail using several measures compared that control participants. Dependent included subjective observer ratings...
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Abstract Pinus massoniana needles, a traditional herb, were applied to prevent hair loss in China. Studies available mainly focused on pine needle flavonoids with various biological activities. However, there has been no pharmacokinetics study of the from needles extract. A selective and sensitive ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS) method was developed simultaneously quantify taxifolin, quercetin catechin rat plasma. To separate three...
A 27-year-old woman presented with odd behavior, seizures, and left arm paroxysmal dyskinesia, more specifically dystonic posturing (video 1 on the Neurology ® Web site at www.neurology.org), no electrographic correlate EEG.The diagnosis of anti-NMDA receptor encephalitis was confirmed by detecting serum CSF antibodies.No ovarian teratoma found, despite its association this syndrome.She improved minimally steroids, IV immunoglobulin, plasmapheresis, but eventually responded to rituximab...
As a pioneer in the field of neuropsychology, Dr. Brenda Milner has contributed to many important landmark discoveries study memory and temporal lobes, lateralization hemispheric function language, as well role frontal lobes problem-solving. She is fellow Royal Society (London) Canada, Foreign Associate National Academy Sciences (USA). been recognized with numerous prestigious awards throughout her career, latest which include Donald O. Hebb Distinguished Contribution Award 2001,...
We have arrived at an exciting juncture in dementia research: the second major pathological hallmark of Alzheimer's disease (AD)–tau–can now be seen for first time living human brain. The proteinopathies AD include amyloid-β plaques and neurofibrillary tangles (NFTs) made hyperphosphorylated paired helical filament (PHF) tau. Since its advent more than a decade ago, amyloid PET imaging has revolutionized field research, enabling confident diagnosis likely pathology patients with variety...
OBJECTIVE: To compare survival in Primary Progressive Aphasia to that behavioral variant FTD (bvFTD) and FTD-ALS identify clinical, demographic pathologic features impacting prognosis. BACKGROUND: PPA is a neurodegenerative syndrome targeting language networks with three major variants: semantic (PPA-S), logopenic (PPA-L) nonfluent/agrammatic (PPA-G). While beginning as focal aphasia, eventually progresses global dementia ultimately death from disease complications. Although the natural...
To explore the physicochemical characteristics and biocompatibility of calcium peroxide (CPO)-loaded polycaprolactone (PCL) microparticle.The CPO/PCL particles were prepared. The morphology elemental distribution CPO, PCL observed with scanning electron microscopy energy dispersive spectroscopy, respectively. Rat adipose mesenchymal stem cells isolated treated different concentrations (0.10%, 0.25%, 0.50%, 1.00%) CPO or particles. cultured in normal media osteogenic differentiation under...
This work proposes an automatic speech recognition (ASR) processor which supports on-chip speaker registration. For noise-robust low-power IoT implementation, we introduce three innovations: a) a two-step training ternary weight net-work inspired ASR system with specified classifiers that can process both verification and keyword spotting; b) addition tree structure based on quality-aware inter-compensation method to achieve high energy efficiency; c) transfer-learning-based backward...