A5101985026- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Bone Tissue Engineering Materials
- Neurofibromatosis and Schwannoma Cases
- Bioactive Compounds and Antitumor Agents
- Neuroblastoma Research and Treatments
- Bone Metabolism and Diseases
- Mesenchymal stem cell research
- Phagocytosis and Immune Regulation
- Synthesis and Reactions of Organic Compounds
- Circular RNAs in diseases
- Axon Guidance and Neuronal Signaling
- Endometriosis Research and Treatment
- RNA Interference and Gene Delivery
- Reproductive System and Pregnancy
- Foot and Ankle Surgery
- Cancer, Hypoxia, and Metabolism
- Synthesis and Biological Evaluation
- Bone and Dental Protein Studies
- Glioma Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Orthopaedic implants and arthroplasty
- TGF-β signaling in diseases
- Tendon Structure and Treatment
Peking University
2018-2025
Peking University Third Hospital
2025
National Clinical Research Center for Digestive Diseases
2020-2024
Ruijin Hospital
2010-2023
Shanghai Jiao Tong University
2015-2023
Wuhan Third Hospital
2023
Tongren Hospital
2023
King University
2020-2023
Stomatology Hospital
2018-2023
Guiyang Medical University
2022
Abstract Paracrine is an important mechanism in mesenchymal stem cells (MSCs) that promotes tissue regeneration. However, anoikis attributed to unsuitable adhesion microenvironment hindered this paracrine effect. In study, a living and injectable porous hydrogel microsphere with long‐term activity constructed via the freeze‐drying microfluidic technology incorporation of platelet‐derived growth factor‐BB (PDGF‐BB) exogenous MSCs. Benefiting from structure superior mechanical property...
Polycaprolactone (PCL) is a polymer material suitable for being prepared into porous scaffolds used in bone tissue engineering, however, insufficient osteogenic ability and mechanical strength limit its application. Zinc (Zn) alloy with proper osteogenesis promising biodegradable metal that have attracted much attention. Herein, we combined the advantages of PCL Zn by fabricating PCL/Zn composite different powder contents (1 wt%, 2 3 wt%) through fused deposition modelling. The mechanical...
Individuals with the neurofibromatosis 1 (NF1) inherited tumor syndrome develop low-grade gliomas (astrocytomas) at an increased frequency, suggesting that NF1 gene is a critical growth regulator for astrocytes. In effort to determine contribution of product, neurofibromin, astrocyte regulation and NF1-associated astrocytoma formation, we generated astrocyte-specific Nf1 conditional knockout mice (Nf1GFAPCKO) by using Cre/LoxP technology. Transgenic were developed in which Cre recombinase...
Despite the characterization of neuroprotection by transforming growth factor-β1 (TGF-β1), signaling pathway mediating its protective effect is unclear. Bad a proapoptotic member Bcl-2 family and inactivated on phosphorylation via mitogen-activated protein kinase (MAPK). This study attempted to address whether MAPK were influenced TGF-β1 and, furthermore, these two events involved in antiapoptotic TGF-β1. We found gradual activation extracellular signal-regulated 1/2 (Erk1/2) MAPK-activated...
We have continued to explore the 3,3-dialkyl-5-aryloxindole series of progesterone receptor (PR) modulators looking for new agents be used in female healthcare: contraception, fibroids, endometriosis, and certain breast cancers. Previously we reported that subtle structural changes with this related templates produced functional switches between agonist antagonist properties ( Fensome et al. Biorg. Med. Chem. Lett. 2002, 12, 3487; 2003, 13, 1317 ). herein report a switch within...
Cerebral cavernous malformations (CCM) are frequent vascular abnormalities caused by mutations in one of the CCM genes. CCM1 (also known as KRIT1) stabilizes endothelial junctions and is essential for morphogenesis mouse embryos. However, cellular functions during early steps pathogenesis remain unknown. We show here that represents an antiangiogenic protein to keep human endothelium quiescent. inhibits proliferation, apoptosis, migration, lumen formation, sprouting angiogenesis primary...
Stem cell properties change over time to match the changing growth and regeneration demands of tissues. We showed previously that adult forebrain stem function declines during aging because increased expression let-7 microRNAs, evolutionarily conserved heterochronic genes reduce HMGA2 expression. Here we asked whether targets also regulate changes between fetal cells. found a second target, RNA binding protein IMP1, is expressed by fetal, but not adult, neural IMP1 was promoted Wnt signaling...
The balance of redox homeostasis is key to stem cell maintenance and differentiation. However, this disrupted by the overproduced reactive oxygen species (ROS) in pathological conditions, which seriously impair therapeutic efficacy cells. In present study, highly dispersed fullerol nanocrystals with enhanced bioreactivity were incorporated into hydrogel microspheres using one-step innovative microfluidic technology construct fullerol-hydrogel spheres (FMSs) for situ regulating cells...
Abstract Apoptotic vesicles (apoVs) are apoptotic cell‐derived nanosized that play a crucial role in multiple pathophysiological settings. However, their detailed characteristics, specific surface markers, and biological properties not fully elucidated. In this study, we compared mesenchymal stem cell (MSC)‐derived apoVs exosomes from three different types of MSCs including human bone marrow (hBMSCs), adipose (hASCs), mouse (mBMSCs). We established unique protein map MSC‐derived identified...
The localization and accumulation of drugs in the body determine their therapeutic effects; however, specific microstructure damaged tissues hinders drug delivery. Currently, there is a shortage effective carriers to breach these barriers achieve efficient tissue cellular delivery drugs. In this study, an injectable double positively charged functional hydrogel microsphere with "targeting cartilage extracellular matrix", "cartilage penetration", "cellular phagocytosis" designed for matching...
Currently, healing of large bone defects faces significant challenges such as a bulk regeneration and revascularization on the defect region. Here, "cell-free scaffold engineering" strategy that integrates strontium (Sr) highly bioactive serum exosomes (sEXOs) inside three-dimensional (3D)-printed titanium (Ti) (Sc) is first developed. The constructed SrTi Sc can serve sophisticated biomaterial platform for maintaining morphological characteristics radius during period critical (CBD) repair...
Abstract Nonalcoholic fatty liver disease (NAFLD) encompasses a broad range of conditions, commencing with simple steatosis and progressing to non‐alcoholic steatohepatitis, the possibility further deterioration into fibrosis, cirrhosis, ultimately, hepatocellular carcinoma. Unfortunately, there is currently no approved medication for treating NAFLD‐associated steatosis. This underscores need improved therapeutic approaches that can modulate lipid metabolism halt transition from chronic...
Oxidized high-density lipoprotein (oxHDL) reduces the ability of cells to mediate reverse cholesterol transport and also shows atherogenic properties. Palmitoylation cluster differentiation 36 (CD36), an important receptor mediating uptake, is required for fatty acid endocytosis. However, relationship between oxHDL CD36 has not been described in mechanistic detail. Here, we demonstrate using acyl-biotin exchange analysis that activates by increasing palmitoylation, which promotes efficient...
Abstract Mesenchymal stem cells (MSCs) are widely used in the treatment of diseases. After their vivo application, MSCs undergo apoptosis and release apoptotic vesicles (apoVs). This study investigates role apoVs derived from human bone marrow mesenchymal (hBMMSCs) metabolism molecular mechanism observed effects. The results show that can promote osteogenesis inhibit osteoclast formation vitro vivo. ApoVs may therefore attenuate loss caused by primary secondary osteoporosis stimulate...
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by massive neovascularization, necrosis, and intense resistance to therapy. Deregulated Notch signaling has been implicated in the formation progression of different malignancies. The present study attempted investigate activation status Dll4-Notch primary human GBM its association with vascular clinical parameters patients.Major components were examined real-time reverse-transcription polymerase chain reaction...