A5110296893- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Nanoparticle-Based Drug Delivery
- Orthodontics and Dentofacial Orthopedics
- Bone Metabolism and Diseases
- Temporomandibular Joint Disorders
- Dental Implant Techniques and Outcomes
- Nanoplatforms for cancer theranostics
- Dental Radiography and Imaging
- MicroRNA in disease regulation
- Osteoarthritis Treatment and Mechanisms
- Polymer Surface Interaction Studies
- dental development and anomalies
- Advanced Nanomaterials in Catalysis
- Estrogen and related hormone effects
- Medical and Biological Sciences
- Advanced biosensing and bioanalysis techniques
- Renal Diseases and Glomerulopathies
- Machine Fault Diagnosis Techniques
- Image and Signal Denoising Methods
- Oral microbiology and periodontitis research
- Inflammatory mediators and NSAID effects
- Gold and Silver Nanoparticles Synthesis and Applications
- Cancer-related molecular mechanisms research
- Medical Imaging and Analysis
Nanjing University
2014-2025
Nanjing University of Posts and Telecommunications
2022-2024
Nanjing Medical University
2010-2024
Zhejiang Chinese Medical University
2021-2024
University of Hong Kong - Shenzhen Hospital
2024
University of Hong Kong
2024
Southern Medical University
2014-2024
Nanfang Hospital
2022-2024
Chengdu University of Traditional Chinese Medicine
2023-2024
Changzhou No.2 People's Hospital
2017-2024
Background: Osteogenic induction and bone formation are heavily affected by environmental factors, including estrogen, estrogen receptors, coregulatory proteins, such as the recently reported proline-, glutamic acid-, leucine-rich protein 1(Pelp1).Objective: To investigate Pelp1 expression in rat mesenchymal stem cells (rBMSCs) during cell proliferation osteogenic differentiation.Methods: rBMSCs were cultured routine differentiation media.Cell was assessed at days 1, 3, 5, 7, 9, 11, 14,...
Abstract Inflammatory cytokines, especially tumor necrosis factor α (TNF-α), have been shown to inhibit osteogenic differentiation of mesenchymal stem cells (MSCs) and bone formation in estrogen deficiency–induced osteoporosis, but the mechanism responsible remains poorly understood. MicroRNAs (miRNAs) regulate MSC differentiation. Here, we identified a novel whereby TNF-α, suppressing functional axis key miRNA (miR-21) contributes osteoporosis. In this study, screened differentially...
Abstract Chronic inflammatory diseases, such as rheumatoid arthritis and periodontitis, are the most common causes of bone tissue destruction. Recently, human periodontal ligament tissue-derived mesenchymal stem cells (PDLSCs), a population multipotent cells, have been used to reconstruct tissues destroyed by chronic inflammation. However, impact local microenvironment on tissue-specific mechanisms controlling effects environment remain poorly understood. In this study, we found that...
Algorithms for signal denoising that combine wavelet-domain sparsity and total variation (TV) regularization are relatively free of artifacts, such as pseudo-Gibbs oscillations, normally introduced by pure wavelet thresholding. This paper formulates wavelet-TV (WATV) a unified problem. To strongly induce sparsity, the proposed approach uses non-convex penalty functions. At same time, in order to draw on advantages convex optimization (unique minimum, reliable algorithms, simplified parameter...
Abstract The differential expression of microRNAs (miRNAs) in plasma gastric cancer (GC) patients may serve as a diagnostic biomarker. A total 33 miRNAs were identified through the initial screening phase (3 GC pools vs. 1 normal control (NC) pool) using quantitative reverse transcription polymerase chain reaction (qRT-PCR) based Exiqon panel (miRCURY-Ready-to-Use-PCR-Human-panel-I + II-V1.M). By qRT-PCR, these further assessed training (30 VS. 30 NCs) and testing stages (71 61 NCs). We...
Dental pulp/dentine complex regeneration is indispensable to the construction of biotissue-engineered tooth roots and represents a promising approach therapy for irreversible pulpitis. We used tissue-engineering method based on odontogenic stem cells design three-dimensional (3D) scaffold-free stem-cell sheet-derived pellet (CSDP) with necessary physical biological properties. Stem were isolated identified from root apical papilla (SCAPs)-based CSDPs then fabricated examined. Compact cell...
Radiotherapy (RT) is a widely explored clinical modality to combat cancer. However, its therapeutic efficacy not always satisfied because of the severe hypoxic microenvironment in solid tumors and high dosage radiation harmful adjacent healthy tissue. Herein, Au nanoparticle-hemoglobin complex nanoparticle loaded platelets (Au-Hb@PLT) were fabricated. These Au-Hb@PLT would be activated by tumor cells, formed platelet-derivate particles (PM) could deliver deeply into tissue their small size...
The preparation, in-vitro release, cytotoxicity, and in-vivo drug delivery of doxorubicin (DOX)-loaded chitosan (CS)-poly(acrylic acid) (PAA) hollow nanospheres were investigated. loading was done by dissolving a certain amount DOX in non-cross-linked CS-PAA aqueous solution followed cross-linking with glutaraldehyde. drug-loading content up to 4.3% the size drug-loaded nanospheres, determined dynamic light scattering, 118 nm. showed continuous release entrapped 10 days vitro comparable...
Peptide-based supramolecular hydrogels have been extensively explored in biomaterials owing to their unique bioactive, stimulus-responsive, and biocompatible features. However, peptide-based often low mechanical stability with storage moduli of 10-1000 Pa. They are susceptible destruction solvent erosion, greatly hindering practical application. Here, we present a photo-cross-linking strategy enhance the hydrogel by 10(4)-fold modulus ~100 kPa, which is one highest reported so far for made...
To compare inner retinal layer (IRL) thickness measured by spectral-domain optical coherence tomography (SD-OCT) and contrast sensitivity (CS) in patients with Parkinson disease (PD) healthy control (HC) subjects.Consecutive without PD were prospectively analyzed using SD-OCT Pelli-Robson CS testing. IRL (ganglion-cell complex) thickness, consisting of the nerve fiber layer, ganglion cell plexiform was segmented an RTVue Model-RT100 EMM5 scan parameter covering a 5.0 × mm cube centered on...
Abstract Background Tissue-engineering strategies based on mesenchymal stem cells (MSCs) and cell sheets have been widely used for periodontal tissue regeneration. However, given the complexity in structure, regeneration methods using a single species of MSC could not fulfill requirement Methods We researched interaction between ligament (PDLSCs) jaw bone marrow-derived (JBMMSCs), constructed composite sheet comprising both above MSCs to regenerate complex periodontium-like structures nude...
The acidity and high GSH level in the tumor microenvironment (TME) greatly limit antitumor activity of nanozymes. Thus, enhancing nanozymes' is fundamentally challenging therapy. Although combination photothermal therapy (PTT) nanozymes can enhance catalytic activity, cancer cells will overexpress heat shock proteins (HSPs) at temperature, aggravating resistance cells, which turn compromises outcome chemodynamic Herein, we propose an iron-doped metal-organic framework nanozyme...
Magnetic hollow Fe3O4–polymer hybrid nanospheres (see figure) were prepared by adding Fe3O4 nanoparticles to an aqueous solution of polymer–monomer pairs composed a cationic polymer (chitosan) and anionic monomer (acrylic acid), followed polymerization acrylic acid selective crosslinking chitosan at the end polymerization.
Magnetic hybrid hollow spheres of about 200 nm were prepared by a core-template-free route, that is, adding Fe3O4 nanoparticles stabilized poly(vinyl alcohol) (PVA) to an aqueous solution polymer−monomer pairs composed cationic polymer, chitosan (CS), and anionic monomer, acrylic acid (AA), followed polymerization selective cross-linking at the end polymerization. The obtained characterized dynamic light scattering (DLS) in observed transmission electron microscopy (TEM), scanning (SEM),...