A5021833545- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer-related gene regulation
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Caveolin-1 and cellular processes
- Mesenchymal stem cell research
- Circular RNAs in diseases
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Phagocytosis and Immune Regulation
- Bioactive Natural Diterpenoids Research
- Bone Metabolism and Diseases
- Kruppel-like factors research
- Molecular Biology Techniques and Applications
- Histone Deacetylase Inhibitors Research
- Cancer Cells and Metastasis
Central South University
2015-2024
Xiangya Hospital Central South University
2019-2024
Beijing Friendship Hospital
2024
Capital Medical University
2015-2024
Sun Yat-sen University
2008-2024
Tibet Autonomous Region People's Hospital
2020-2024
Shanghai Sixth People's Hospital
2015-2022
Shanghai Jiao Tong University
2015-2022
Ministry of Health
2020-2022
Ministry of Education of the People's Republic of China
2013-2022
Abstract Vascularization deficiency caused a lot of diseases, such as diabetes ulcer and myocardial infarction. Mesenchymal stem cells (MSCs), with the self-renewal multipotent differentiation capacities, have been used for many diseases treatment through regulation microenvironment. Numerous studies reported that MSCs transplantation could largely improve cutaneous wound healing via paracrine secretion growth factors. However, whether take part in angiogenesis process directly remains...
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. However, a biomarker for sensitive and simple diagnostic test highly effective target therapy CRC still clinically unavailable. This study to investigate evidence significance plasma GPC1 positive exosomes as CRC. Results showed that GPC1+ were successfully isolated from tissues plasma. The percentage protein expression in tumour patients before surgical treatment was significantly elevated compared...
As the major interface between body and external environment, skin is liable to various injuries. Skin injuries often lead severe disability, exploration of promising therapeutic strategies great importance. Exogenous mesenchymal stem cell (MSC)-based therapy a potential strategy due apparent effects, while underlying mechanism still elusive. Interestingly, we observed extensive apoptosis exogenous bone marrow cells (BMMSCs) in short time after transplantation mouse wound healing models....
Abstract Background Nasopharyngeal carcinoma (NPC) is a common malignant tumor in southern China and Southeast Asia, but its molecular mechanisms of pathogenesis are poorly understood. Our previous work has demonstrated that BCAT1 mRNA over expressed NPC knocking down expression 5-8F cell line can potently inhibit cycle progression proliferation. However, the mechanism up-regulation functional role development remain to be elucidated yet. Methods Immunohistochemistry (IHC) method was...
Skin serves as the major interface between external environment and body which is liable to many kinds of injuries. Mesenchymal stem cell (MSC) therapy has been widely used became a promising strategy. Pre-treatment with chemical agents, hypoxia or gene modifications can partially protect MSCs against injury, pre-treated show improved differentiation, homing capacity, survival paracrine effects regard attenuating injury. The aim this study was investigate whether exosomes from educated...
The elevation of oxidative stress preferentially in cancer cells by inhibiting thioredoxin reductase (TrxR) and/or enhancing reactive oxygen species (ROS) production has emerged as an effective strategy for selectively targeting cells. In this study, we designed and synthesized 21 ligustrazine-curcumin hybrids (10a-u). Biological evaluation indicated that the most active compound 10d significantly inhibited proliferation drug-sensitive (A549, SPC-A-1, LTEP-G-2) drug-resistant (A549/DDP) lung...
Zinc (Zn) is a bioabsorbable metal that shows great potential as an implant material for orthopedic applications. Suitable concentrations of zinc ions promote osteogenesis, while excess cause apoptosis. As result, the conflicting impacts Zn
// Jian Li 1 , Bo 2 Caiping Ren 3 Yuxiang Chen 4 Xiong Guo Lin Zhou Zha Peng Yaping Tang Yang Weidong Liu Bin Zhu Lei Wang Xuxu Xiao Shi and Zixuan Hepatobiliary Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China Department of Pathology, Medical School, 410078, Cancer Institute, Collaborative Innovation Center for Medicine, Key Laboratory Carcinogenesis Chinese Ministry Health, School Basic Science, Pharmaceutical 410013, Correspondence...
// Wenting Jia 1 , Caiping Ren Lei Wang Bin Zhu Wei Menghui Gao Fei Zeng 2 Liang 3 Xiaomeng Xia 4 Xiaobing Zhang 5 Ting Fu Shasha Li Can Du 6 Xingjun Jiang Yuxiang Chen 7 Weihong Tan Zilong Zhao Weidong Liu Cancer Research Institute, Collaborative Innovation Center for Medicine, Key Laboratory Carcinogenesis of Chinese Ministry Health, School Basic Medical Science, Central South University, Changsha, Hunan, P. R. China Department Gynecology and Obstetrics, The Third Xiangya Hospital, Hunan...
Osteosarcoma (OS) is a high-grade bone sarcoma with early metastasis potential, and the clinical chemotherapy drugs that are currently used for its treatment have some limitations. Recently, several studies reported selective antitumor effect of oleandrin on various tumor cells. In this study, we aimed to evaluate effects underlying mechanisms OS The proliferation, morphology, apoptosis U2OS SaOS-2 cells were analyzed in vitro. activity Wnt/β-catenin signaling pathway was determined using...
Abstract Lipid raft proteins have been confirmed to be important in cell signal transduction. Some reports shown that the aberrant expression of lipid is associated with malignant phenotypes some cancers. However, role protein flotillin-2 (Flot-2) nasopharyngeal carcinoma (NPC) remains comprehensively characterized. Here, overexpression Flot-2 NPC tissues and lines was detected by immunostaining found positively metastasis. Furthermore, inhibiting impaired malignancy highly metastatic line...
Increasing evidence demonstrates that dysregulation of XBP1 function contributes to tumorigenesis in some cancers. However, little is known about the role progression osteosarcoma (OS). The expression OS samples was measured by quantitative RT-PCR and Western blotting assays. Cell cycle analysis cell counting kit 8 (CCK8) assays were performed determine effects on cells growth capacity. apoptosis coassay applied survival. genes affected examined RT-RCR validated overexpressed clinical...
Allelic loss of chromosome 3p, including the 3p21.3 region, is found in 95-100% primary nasopharyngeal carcinoma (NPC) biopsies, suggesting that this region should harbor some tumor suppressor genes (TSGs) closely related to NPC development. Several TSGs located at 3p21.3, such as RASSF1A, LTF and BLU, have been demonstrated be involved LARS2 (leucyl-tRNA synthetase 2, mitochondrial) another gene 3 common eliminated region-1 (C3CER1) 3p21.3. In study, we focussed on epigenetic genetic...
Phospholipase C (PLC) is a pivotal enzyme in the phosphoinositide pathway that promotes second messengers, diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), to participate eukaryotic signal transduction. Several PLC isozymes are associated with cancer, such as PLC-β1, PLC-δ1, PLC-ε PLC-γ1. However, role of PLC-δ3 (PLCD3) nasopharyngeal carcinoma (NPC) has not been investigated date. In our previous study, we demonstrated flotillin2 (Flot2) plays pro-neoplastic NPC involved tumour...
Osteosarcoma (OS) is a kind of malignant bone tumor that occurs frequently in the region surrounding knee joint and poses threat to health teenagers.Since application chemotherapy treat OS, 5-year survival rate patients has improved from 10% 70%, but patient not changed over past four decades.Coactivator-associated arginine methyltransferase 1 (CARM1) member PRMT protein family; it acts as an oncogene many cancers, its function OS still unknown.In this study, we found CARM1 overexpressed...