A5100430688- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- NF-κB Signaling Pathways
- Natural product bioactivities and synthesis
- Bioactive Compounds and Antitumor Agents
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Mycobacterium research and diagnosis
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Inflammatory mediators and NSAID effects
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- RNA regulation and disease
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
Gansu Provincial Hospital
2022-2024
First Hospital of Jilin University
2023
Jilin University
2023
Shanghai Jiao Tong University
2017-2022
Shanghai Sixth People's Hospital
2022
Peking Union Medical College Hospital
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Weifang People's Hospital
2019-2021
Shandong University
2020-2021
Shandong First Medical University
2021
Abstract The level of microRNA-205 (miR-205) is commonly deregulated in a number cancers. Through the screening microRNA expression profile bladder cancer tissue and cell lines, we found that miR-205 was significantly suppressed. In addition, levels had negative correlation with degree malignancy. However, biological functions remained unclear. this study, have demonstrated role inhibition proliferation, migration invasion cells. Moreover, identified cyclin J ( CCNJ) gene, which involved...
MicroRNAs (miRNAs) have been reported to play critical roles in tumor progression including hepatocellular carcinoma (HCC). Thus, the underlying mechanisms need further investigation. Previous study that loss of miR-345 expression indicated a poor prognosis HCC patients. This evaluated whether could promote metastasis and epithelial-mesenchymal-transition (EMT) by targeting interferon regulatory factor 1 (IRF1)-mediated mTOR/STAT3/AKT signaling. Underexpression was identified 65 cases human...
Emerging evidence has showed that long non-coding RNA (lncRNA) play an important role in the occurrence and development of various cancers. In present study, expression level lincRNA-p21 was investigated hepatocellular carcinoma (HCC), its invasion HCC also explored.The levels human tumor tissue cell lines HepG2 SMMC-7721 were determined by real-time polymerase chain reaction. Transfected cells with pcDNA-lincRNA-p21 or si-lincRNA-p21 for overexpression downregulation lincRNA-p21, Notch...
Despite the emerging insights into many snoRNAs (small nucleolar RNAs) which are detectable in body fluids and serve as noninvasive biomarkers, few studies have previously discussed role of tumor-educated platelets (TEPs). Herein, we systematically estimated dysregulation non-small cell lung cancer (NSCLC) clarified biomarker potential SNORD55 platelets.We compared expression between NSCLC normal tissues using SNORic datasets. Platelets were isolated from plasma low-speed centrifugation...
Small nuclear RNA (snRNA) levels are extremely variable across a wide range of biological conditions. SnRNAs could potentially regulate alternative splicing to drive genetic, dysplastic and neoplastic disease, which might be the main reason for mRNA profile alteration in tumor educated platelets (TEPs).Platelets were isolated from plasma lung cancer patients healthy donors by low-speed centrifugation subjected isolation. SnRNA U1, U2, U5 detected quantitative real-time polymerase chain...
Exosomes derived from cancer cells encapsulate various kinds of tumor-specific molecules and thus can interact with adjacent or distant to mediate information exchange. Long non-coding RNAs (lncRNAs) in exosomes have the potential as diagnostic prognostic biomarkers different types cancers. The current study was aimed identify circulating exosomal lncRNAs for diagnosis colorectal (CRC). were isolated serum by ultracentrifugation verified transmission electron microscope (TEM), qNano,...
To explore the expression and clinical significance of long noncoding RNA (lncRNA) gastric cancer-associated transcript 3 (GACAT3) in human colorectal cancer (CRC).Expression GACAT3 CRC tissues cell lines was measured using quantitative real-time PCR. CCK-8 colony formation assays were used to assess effect on line proliferation. Transwell invasion migration performed detect migration. Bioinformatics prediction, luciferase reporter assay, pull-down assay determine if miR-149 a target GACAT3....
Sarcopenia induced by muscle aging is associated with negative outcomes in a variety of diseases. Long non-coding RNAs are class longer than 200 nucleotides lower protein coding potential. An increasing number studies have shown that lncRNAs play vital role skeletal development. According to our previous research, lncRNA GPRC5D-AS1 selected the present study as target gene further its effect on dexamethasone-induced human atrophy cell model. As result, functions ceRNA miR-520d-5p repress...
Colorectal cancer is one of the commoner digestive tract malignant tumor types, and its incidence mortality rate are high. Accumulating evidence indicates that long‑chain non‑coding RNAs (lncRNAs) protein‑coding interact with each other by competing same micro(mi)RNA response element (MREs) serve an important role in regulation gene expression a variety types. However, regulatory mechanism prognostic lncRNA‑mediated endogenous (ce)RNA networks colon have yet to be elucidated. The profiles...
Background Gastric cancer is a very common gastrointestinal tumor with high mortality rate. Nintedanib has been shown to significantly reduce cell proliferation and increase apoptosis in gastric cells vitro . However, its systemic action mechanism on remains unclear. A high-throughput proteomic approach should help identify the potential mechanisms targets of nintedanib cells. Methods The effects biological behavior were evaluated. cytotoxic assay was performed estimate half maximal...
Abstract Despite great advancements in the treatment of non-Hodgkin lymphoma (NHL), sensitivity different subtypes to therapy varies. Targeting aberrant activation NF- κ B signaling pathways lymphoid malignancies is a promising strategy. Here, we report that 11(13)-dehydroivaxillin (DHI), natural compound isolated from Carpesium genus, induces growth inhibition and apoptosis NHL cells. Multiple cascades are influenced by DHI PI3K/AKT ERK activated or inhibited cell type dependent manner,...
Background: Integrin beta-like 1 (ITGBL1) was extensively demonstrated to contribute the metastasis and progression in a variety of cancers. However, its role ITGBL1 prostate cancer (PCa) is still not reported. Methods: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) western blot were performed detect expression PCa tissues cell lines. Immunohistochemical (IHC) staining 174 performed. The influence ITGL1 cells epithelial-mesenchymal transition (EMT), migration invasion...
The long intergenic non-protein coding RNA 1094 (LINC01094) plays a vital role in the oncogenicity of clear cell renal carcinoma. However, its expression profile and detailed roles glioblastoma (GBM) remain unknown. In this study, we mainly investigated LINC01094 GBM focused on mechanism by which regulates malignant characteristics GBM.LINC01094 was determined with quantitative reverse transcription polymerase chain reaction. proliferation, apoptosis, migration, invasion vitro, tumor growth...
Ischemic stroke is a devastating condition with high burden of neurological disability and death. The aim this study was to explore the potential long noncoding RNA (lncRNA) biomarkers underlying mechanism stroke. Subpathway-LNCE method, which specifically designed identify lncRNAs competitively regulated functions in diseases, applied ischemic dataset ischemic-stroke-associated dysfunctional subpathway that by lncRNAs. At first, based on shared microRNA (miRNA) between miRNA-messenger...
Background . lncRNA and microRNA affect the occurrence development of many diseases, so they are expected to become diagnostic or predictive indicators. But relationship between FGD5‐AS1 miR‐130a prognosis chronic periodontitis is still unclear. The purpose this study explore prognostic value two in periodontitis. Objective This set out investigate Methods Eighty‐seven patients with who visited our hospital from March 2016 August 2017 were collected as an observation group (OG), 72 subjects...
Osteosarcoma (OS) is one of the most malignant bone tumors and has a high metastatic rate. Increasing research demonstrated vital roles long noncoding RNAs (lncRNAs) in human cancers, including OS. LncRNA LINC00662 been revealed to act as an oncogene involved multiple tumor progression. This study aimed investigate expression pattern, function, regulatory mechanism OS.Patients who underwent OS surgery were this study. Experiments RT-qPCR, MTT, western blot, FISH, RNA pull-down, luciferase...
Maternal overnutrition during pregnancy and lactation is an important risk factor for the later development of metabolic disease, especially diabetes, among mothers their offspring. As a fructan-type plant polysaccharide, inulin has prebiotic functions widely used as natural antidiabetic supplement. However, to date, mechanism maternal treatment in livers offspring not been addressed, with respect long noncoding RNAs (lncRNAs). In this study, female C57BL6/J mice were fed either high-fat...
Gallbladder carcinoma (GBC) remains a highly lethal disease worldwide. MiR-552 family members promote the malignant progression of variety digestive system tumors, but role miR-552-3p in GBC has not been elucidated. was predicted to target 3'-untranslated region (3'UTR) mRNA for tumor suppressor gene "repulsive guidance molecule BMP co-receptor a" (RGMA). The aim present study clarify roles and mechanisms targeting RGMA GBC.In vitro: expression detected by real-time quantitative PCR...