A5061202285- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- MicroRNA in disease regulation
- RNA Research and Splicing
- Bioinformatics and Genomic Networks
- Immune cells in cancer
- Cancer-related gene regulation
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Computational Drug Discovery Methods
- Signaling Pathways in Disease
- Cancer Genomics and Diagnostics
- Gut microbiota and health
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Air Quality and Health Impacts
- Cardiac Fibrosis and Remodeling
- Energy and Environment Impacts
- RNA and protein synthesis mechanisms
- Extracellular vesicles in disease
- NF-κB Signaling Pathways
- Genetic Associations and Epidemiology
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
Feed Research Institute
2023-2025
Sun Yat-sen University
2024-2025
National Institute of Biological Sciences, Beijing
2025
Ministry of Agriculture and Rural Affairs
2023-2025
Southern University of Science and Technology
2024-2025
South China University of Technology
2025
Harbin Medical University
2020-2024
Shanghai Jiao Tong University
2017-2024
Affiliated Hospital of Nantong University
2021-2024
Nantong University
2021-2024
Abstract Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and they play fundamental roles in immune regulation. Here we introduce an integrated algorithm, ImmLnc, for identifying lncRNA immune-related pathways. We comprehensively chart the landscape regulation immunome across 33 cancer types show that cancers with similar tissue origin likely to share regulators. Moreover, lncRNAs perturbation significantly correlated cell infiltration. ImmLnc can help...
Pseudomonas aeruginosa alkaline protease and elastase are thought to contribute bacterial invasiveness, tissue damage, immune suppression in animals patients infected with the bacterium. This study examined ability of two proteases inactivate a number cytokines that mediate inflammatory responses. Human recombinant gamma interferon (rIFN-gamma) human tumor necrosis factor alpha were inactivated by both proteases. Murine rIFN-gamma was relatively resistant but elastase, interleukin-1 beta...
Tissue clearing combined with high-resolution confocal imaging is a cutting-edge approach for dissecting the three-dimensional (3D) architecture of tissues and deciphering cellular spatial interactions under physiological pathological conditions. Deciphering interaction leptin receptor-expressing (LepR+) stromal cells other compartments in bone marrow crucial deeper understanding stem cell niche skeletal tissue. In this study, we introduce an optimized protocol 3D analysis tissues, enabling...
Understanding tumor heterogeneity is a major challenge that was recognized as one of the first Cancer Grand Challenges, with call to provide solutions visualize heterogeneity. The Rosetta team took on this challenge, exploiting advances in spatial-omics approaches centered around mass spectrometry imaging map at cellular and molecular scales different levels resolution. See related article by Bressan et al., p. 16 Stratton 22 Bhattacharjee 28.
Background: Solid fuels are widely used in China. Household air pollution from the burning of solid may increase risk chronic obstructive pulmonary disease (COPD), but prospective evidence is limited. Objectives: We examined association fuel use for cooking and heating with COPD a cohort study. Methods: Participants were China Kadoorie Biobank. Current previous household self-reported at baseline 2004–2008. In present study, “solid fuels” refers to coal wood, whereas “cleaner energy sources...
<title>Abstract</title> MicroRNAs (miRNAs) are small non-coding RNAs that participate in the spatiotemporal regulation of messenger RNA and protein synthesis. Aberrant miRNA expression leads to developmental abnormalities diseases. The miR-135a is considered be oncogenic; however, functions mechanisms colorectal cancer (CRC) largely unknown. Thus, we investigated miR-135a, especially its relationship with metastasis suppressor 1 (<italic>MTSS1</italic>) gene CRC. was determined by real-time...
Abstract Aberrant DNA methylation is a fundamental characterization of epigenetics for carcinogenesis. Abnormality methylation-related functional elements (DMFEs) may lead to dysfunction regulatory genes in the progression cancers, contributing prognosis many cancers. There an urgent need construct tool comprehensively assess impact DMFEs on prognosis. Therefore, we developed SurvivalMeth (http://bio-bigdata.hrbmu.edu.cn/survivalmeth) explore prognosis-related DMFEs, which documented kinds...
Abstract Background Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and play fundamental roles in various types cancer. Current developments transcriptome analyses unveiled the existence lncRNAs; however, their functional characterization remains a challenge. Methods A bioinformatics screen was performed by integration multiple omics data hepatocellular carcinoma (HCC) prioritizing novel oncogenic lncRNA, LINC01132. Expression LINC01132 HCC control...
Abstract Accumulating evidence has demonstrated that transcriptional regulation is affected by DNA methylation. Understanding the perturbation of methylation-mediated between factors (TFs) and targets crucial for human diseases. However, global landscape dysregulation (DMTD) across cancers not been portrayed. Here, we systematically identified DMTD integrative analysis transcriptome, methylome regulatome 22 cancer types. Our results revealed was methylation, involving hundreds...
Modified citrus pectin (MCP) is a specific inhibitor of galectin-3 (Gal-3) that regarded as new biomarker cardiac hypertrophy, but its effect unclear. The aim this study to investigate the role and mechanism MCP in isoproterenol (ISO)-induced hypertrophy. Rats were injected with ISO induce hypertrophy treated MCP. Cardiac function was detected by ECG echocardiography. Pathomorphological changes evaluated haematoxylin eosin (H&E) wheat germ agglutinin (WGA) staining. hypertrophy-related genes...
RNA-binding proteins (RBPs) are key players of gene expression and perturbations RBP-RNA regulatory network have been observed in various cancer types. Here, we propose a computational method, RBPreg, to identify the RBP regulators by integration single cell RNA-Seq (N = 233,591) binding data. Pan-cancer analyses suggest that exhibit specificity involved hallmark-related functions. We prioritize an oncogenic RBP-HNRNPK, which is highly expressed tumors associated with poor prognosis...
Abstract Background It is well-established that understanding the mechanism of prostate cancer (PCa)-associated metastasis paramount for improving its prognosis. Metastasis known to involve communication between tumor-associated macrophages (TAMs) and tumor cells. Exosomes are crucial in mediating this intercellular within microenvironment. Nonetheless, role exosomal proteins PCa not yet fully understood. Here, we investigated mechanisms cancer-derived PSM-E on regulating macrophage M2...
Colorectal cancer (CRC) is a common malignant gastrointestinal cancer. Efforts for preventive and personalized medicine have intensified in the last decade with attention to novel forms of biomarkers. In present study, microRNA genetic analyses were performed tandem differential transcriptome profiling between primary tumors or without nodes distant metastases. Serial Test Cluster (STC) analysis demonstrated that 20 genes two microRNAs showed distinctive expression patterns associated tumor,...
Regulation of gut microbiota and modulation bile acid (BA) composition are potential strategies for the treatment intestinal inflammation. This study aimed to investigate effect grape seed proanthocyanidin (GSP) on inflammation understand its mechanism. C57BL/6J male mice (7-8 weeks old) were used in experiments. Antibiotics applied deplete evaluate contribution dietary GSP. Intestinal-specific farnesoid X receptor (FXR) inhibitor was analyze role FXR signaling. In this study, GSP alleviated...
<div>Summary:<p>Understanding tumor heterogeneity is a major challenge that was recognized as one of the first Cancer Grand Challenges, with call to provide solutions visualize heterogeneity. The Rosetta team took on this challenge, exploiting advances in spatial-omics approaches centered around mass spectrometry imaging map at cellular and molecular scales different levels resolution.</p><p><a...
<p>Cancer Research UK Rosetta Grand Challenge consortium list of members</p>
<p>Cancer Research UK Rosetta Grand Challenge consortium list of members</p>
To investigate the relationship between newly identified senataxin (SETX) gene mutations and clinical manifestation of Amyotrophic Lateral Sclerosis (ALS), enhancing understanding genetic underpinnings associated with this disorder. A cohort study was conducted at Nanfang Hospital, involving comprehensive sequencing ALS patients to identify novel SETX mutations. Homology modelling structural analysis were employed predict functional impacts these on protein. Clinical assessments, including...
The disposal of increased quantities dewatered sewage sludge to landfills may cause geoenvironmental problems such as leachability, total and differential settlement, slope stability the waste during disposal. This study investigates geotechnical properties generated from chemically enhanced primary treatment (CEPT) in Hong Kong. Compaction test results show that CEPT exhibits compaction characteristics similar those clayey soils; however, lowest hydraulic conductivity does not occur near...
Recent studies have indicated that peroxisome proliferator-activated receptor gamma (PPARγ) is capable of modulating inflammation, which prompted us to investigate the potential PPARγ ligands as lung protective agents in pulmonary fibrosis. The present study was undertaken effects rosiglitazone (RSG), a highly potent ligand PPARγ, on migration, proliferation, and phenotypic differentiation human fibroblasts (MRC-5) explore its for therapy cell migration observed scratch wound model. Cell...
Succinate dehydrogenases (SDH), including SDHA, SDHB, SDHC, and SDHD, form the respiratory complex II in mitochondria play an important role cell growth homeostasis. In order to evaluate expression functional significance of SDH colorectal cancer, four subunits was analyzed, SDHB protein found be significantly lower cancer tissues. vitro experiments assay, colony formation cycle analysis, nude mouse xenograft SDHB-transfected line SW620 were performed. Notably, reduced tumor tissues...
Osteosarcoma is the most common type of human primary malignant bone tumor with a potential propensity for local invasion and distant metastasis. Thus, this study focused on expression roles IRX2 in development osteosarcoma. The mRNA levels tissue samples 69 cases osteosarcoma were detected by quantitative polymerase chain reaction assay. associations between pathological features tissues analyzed. Functional studies performed MTT Matrigel assays following knockdown lentivirus vector....