A5103005461- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Bioinformatics and Genomic Networks
- Cancer Genomics and Diagnostics
- Computational Drug Discovery Methods
- Liver Disease Diagnosis and Treatment
- Topic Modeling
- Neural Networks and Applications
- Porphyrin and Phthalocyanine Chemistry
- Synthesis and Characterization of Pyrroles
- Semantic Web and Ontologies
- Diet and metabolism studies
- Drug-Induced Hepatotoxicity and Protection
- Data Stream Mining Techniques
- Genetics, Bioinformatics, and Biomedical Research
- Gut microbiota and health
- 3D Printing in Biomedical Research
- Single-cell and spatial transcriptomics
- Liver Disease and Transplantation
- Building Energy and Comfort Optimization
- Advanced Multi-Objective Optimization Algorithms
- Autophagy in Disease and Therapy
- Maternal and Perinatal Health Interventions
- Tryptophan and brain disorders
- Peripheral Nerve Disorders
Indian Veterinary Research Institute
2024-2025
Central University of Punjab
2025
National Physical Laboratory
2025
All India Institute of Medical Sciences, Deoghar
2025
MIT World Peace University
2024
Hadassah Medical Center
2024
Carnegie Mellon University
2024
Institute of Bioinformatics and Applied Biotechnology
2024
Indian Institute of Technology Delhi
2018-2022
Queen Mary University of London
2018-2022
Abstract Isolation of metastatic circulating tumor cells (CTCs) from cancer patients is high value for disease monitoring and molecular characterization. Despite the development many new CTC isolation platforms in last decade, their detection has remained a challenge due to lack specific sensitive markers. In this feasibility study, we present method based on binding malaria rVAR2 protein oncofetal chondroitin sulfate (ofCS). We show that efficiently captures CTCs hepatic, lung, pancreatic,...
Patient-derived in vivo models of human cancer have become a reality, yet their turnaround time is inadequate for clinical applications. Therefore, tailored ex that faithfully recapitulate tumour biology are urgently needed. These may especially benefit the management pancreatic ductal adenocarcinoma (PDAC), where therapy failure has been ascribed to its high stem cell (CSC) content and density stromal cells extracellular matrix (ECM). To date, these features only partially reproduced using...
Understanding tumor heterogeneity is a major challenge that was recognized as one of the first Cancer Grand Challenges, with call to provide solutions visualize heterogeneity. The Rosetta team took on this challenge, exploiting advances in spatial-omics approaches centered around mass spectrometry imaging map at cellular and molecular scales different levels resolution. See related article by Bressan et al., p. 16 Stratton 22 Bhattacharjee 28.
ABSTRACT The PI3K–mTOR–AKT pathway regulates tumour proliferation, gene expression and metabolism, but inhibition induces heterogeneous feedback reactivation, limiting anti-tumour responses. Measuring heterogeneity of in tissues using protein biomarker phosphorylation or location is challenging. An integrated multi-modal imaging workflow was developed to assess the AZD2014 (mTORC1/2 inhibitor) response a PTEN-null renal cancer model. Spatial responses metabolite biomarkers were analysed by...
Epithelial to Mesenchymal transition (EMT) drives cancer metastasis and is governed by genetic epigenetic alterations at multiple levels of regulation. It well established that loss/mutation p53 confers oncogenic function cells promotes metastasis. Though transcription factors like ZEB1, SLUG, SNAIL TWIST have been implied in EMT signalling, mediated the machinery accompanying are not clearly understood. This work attempts explore signalling during colorectal (CRC) with varying status p53....
Sirtuins belong to the family of class III histone deacetylases; its role in neoplasia is controversial as both tumor-suppressive and promoting functions have been reported. There are very few reports available, where expressions sirtuin isoforms comprehensively analyzed during neoplasia. Therefore, present study, expression SIRT1, SIRT2, SIRT7 different stages cervical cancer progression was analyzed. The normal epithelium showed feeble isoforms, SIRT7. A significant increase SIRT1 noted...
Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide and hepatitis B one commonest causes. T regulatory cells (Tregs) are strong immunomodulators likely to play a major role in HCC development. HBV infection reported induce expansion Tregs. We investigated CD4+CD25+CD127(-ve)FoxP3+ Tregs HBV-related as compared non-HBV-HCC.Whole blood immunophenotyping was analyzed by multicolor flow cytometry patients with (HBV-HCC, n = 17), non-HBV-HCC (n 22; NASH 16,...
We collated publicly available single-cell expression profiles of circulating tumor cells (CTCs) and showed that CTCs across cancers lie on a near-perfect continuum epithelial to mesenchymal (EMT) transition. Integrative analysis CTC transcriptomes also highlighted the inverse gene pattern between PD-L1 MHC, which is implicated in cancer immunotherapy. used tandem with peripheral blood mononuclear cell (PBMC) train classifier accurately recognizes diverse phenotype. Further, we this validate...
<div>Summary:<p>Understanding tumor heterogeneity is a major challenge that was recognized as one of the first Cancer Grand Challenges, with call to provide solutions visualize heterogeneity. The Rosetta team took on this challenge, exploiting advances in spatial-omics approaches centered around mass spectrometry imaging map at cellular and molecular scales different levels resolution.</p><p><a...
<p>Cancer Research UK Rosetta Grand Challenge consortium list of members</p>
<p>Cancer Research UK Rosetta Grand Challenge consortium list of members</p>
Forensic science has made tremendous strides in recent years, making it challenging to draw comparisons with older investigation methods. One of the groundbreaking advancements is use DNA technology forensics. A cutting-edge technique called "familial searching" involves deliberately scouring a database find matches limited set genetic markers. This approach aims identify potential relatives an unknown individual, providing new leads for investigations. The FBI oversees CODIS database, which...
Alpha-synucleinopathies, characterized by extracellular alpha-synuclein (αSyn or SNCA) accumulation and aggregation, have been linked to neurological disorders including Parkinson’s disease multiple system atrophy. P2RX7 is a non-selective cationic transmembrane purinergic receptor activated elevated levels of ATP, which typically occurs during inflammatory conditions. Activation αSyn implicated in neuronal degeneration, potentially causing pore dilation increased inflammation. By...
A transition metal-free, base mediated approach has been devised for the synthesis of novel densely functionalized alkenes containing isocyanide, nitrile and ester functionalities. The strategy was found applicable to gram-scale a library with significant diversity developed. It that could also be used trisubstituted pyrrole derivatives by modifying reaction conditions. advantages this are operationally simple procedure, short time (10-30 min), broad substrate scope, high atom economy,...
Background Plain language summaries (PLSs) make scientific research accessible to a broad non-expert audience. However, crafting effective PLS can be challenging, particularly for non-native English-speaking researchers. Large model (LLM) chatbots have the potential assist in generating summaries, but their effectiveness compared human-generated remains underexplored. Methods This cross-sectional study 30 human-written with LLM chatbot (viz., ChatGPT (OpenAI, San Francisco, CA), Claude...
A transition metal-free, Cs2CO3-promoted approach has been devised for the efficient synthesis of nitrile-substituted novel pyrrole derivatives from β-chlorovinyl aldehydes. Interestingly, strategy was also found to be applicable chromenone-fused derivatives. The reaction proceeded through [3 + 2] cycloaddition between diversely substituted aryl propiolonitriles and toluenesulphonylmethyl isocyanide in DMF at ambient temperature. This offers several advantages including use inexpensive...
Cytokines and growth factors have prominent roles in liver regeneration. The aim of this study was to evaluate the biological markers regeneration healthy donors undergoing right lobe donor hepatectomy for living transplantation. Twenty‐five voluntary were enrolled. Peripheral blood samples taken a day before operation on postoperative days (PODs) 1, 3, 7, 14, 42. Levels hepatocyte factor (HGF), interleukin (IL) 6, tumor necrosis α (TNF‐α), thrombopoietin (TPO), transforming β1 (TGF‐β1),...
Various types of faults can occur in an air conditioner resulting a decrease efficiency, rise energy consumption, and increasing maintenance costs. Hence predictive becomes important. In this paper, the two most common - gas leakage capacitor malfunction have been detected using decision tree machine learning algorithm. The data for faulty operating conditioners collected distributed sensors, microcontroller, dedicated circuitry analyzed MATLAB Classification App Learner Toolbox. results...