A5039917534- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Organ Transplantation Techniques and Outcomes
- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Hepatitis C virus research
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Liver Diseases and Immunity
- Hepatitis Viruses Studies and Epidemiology
- Electrolyte and hormonal disorders
- Hepatitis B Virus Studies
- Liver physiology and pathology
- Renal Transplantation Outcomes and Treatments
- Mitochondrial Function and Pathology
- Immune Response and Inflammation
- Drug Transport and Resistance Mechanisms
- Immune cells in cancer
- Immune Cell Function and Interaction
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Viral gastroenteritis research and epidemiology
University College London
2017-2025
Charité - Universitätsmedizin Berlin
2020-2025
The Royal Free Hospital
2017-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2021-2024
Humboldt-Universität zu Berlin
1961-2024
Freie Universität Berlin
2022-2024
Leipzig University
2019-2024
University Hospital Leipzig
2013-2022
University of Gothenburg
2022
Reykjavík University
2022
Direct-acting oral anticoagulants (DOACs) are used in patients with splanchnic vein thrombosis (SVT) and cirrhosis, but evidence for safety efficacy this setting is limited. Our aim was to identify indications reasons starting or switching DOACs report adverse effects, complications short-term outcome.Data collection including demographic information, laboratory values, treatment through the Vascular Liver Disease Interest Group Consortium.Forty-five centres (90%) of consortium completed...
Based on positive results from small single center studies, granulocyte-colony stimulating factor (G-CSF) is being widely used for the treatment of patients with acute-on-chronic liver failure (ACLF). Herein, we aimed to evaluate safety and efficacy G-CSF in ACLF.In this multicenter, prospective, controlled, open-label phase II study, 176 ACLF (EASL-CLIF criteria) were randomized receive (5 μg/kg daily first 5 days every third day thereafter until 26) plus standard medical therapy (SMT) (n =...
Acute-on-chronic liver failure (ACLF) is a severe complication of cirrhosis and defined by organ high rates short-term mortality. Patients with ACLF are managed multiorgan support in the intensive care unit (ICU). Currently, it unclear when this supportive becomes futile, particularly patients who not candidates for transplant. The aim study was to determine whether currently available prognostic scores can identify whom prolonged ICU likely be futile despite maximal treatment efforts.Data...
•We hypothesised that a TLR4 inhibitor, TAK-242, might mitigate the negative effects of G-CSF in ACLF.•G-CSF alone increases mortality and promotes inflammation rodent models ACLF.•The combination TAK-242 inhibits inflammation, hepatic regeneration prevents ACLF. Background & AimsAcute-on-chronic liver failure (ACLF) is characterised by high short-term mortality, systemic regeneration. Its treatment major unmet medical need. This study was conducted to explore whether combining Toll-like...
Summary Background Refractory ascites ( RA ) is a frequent complication of cirrhosis, requiring large volume paracentesis or placement transjugular intrahepatic portosystemic shunt (TIPSS ). The automated low‐flow pump (alfapump, Sequana Medical AG, Zurich, Switzerland) an innovative treatment option for patients with . Aim To assess safety and efficacy this in contraindication to TIPSS Methods Fifty‐six (43 males; mean age 62 years) from centres Germany, Switzerland, UK Spain were included...
To evaluate medical versus interventional treatment (transjugular thrombus fragmentation, local thrombolysis with or without stent implantation) in patients acute non-cirrhotic, non-malignant portal vein thrombosis (PVT).This prospective, observational study enrolled 65 (<28 days since begin of symptoms, no cavernoma) PVT nine centres. Thirty received and 35 treatment. was graded into grade 1: short incomplete occlusion the vessel lumen 2: extended complete occlusion. Treatment response...
Abstract Background Patients with cirrhosis and ascites (and portal hypertension) are at risk of developing acute kidney injury (AKI). Although many etiologies exist, hepatorenal AKI (HRS-AKI) remains a frequent difficult-to-treat cause, very high mortality when left untreated. The standard care is the use terlipressin albumin. This can lead to reversal AKI, which associated survival. Nevertheless, only approximately half patients achieve this even after for new episodes HRS-AKI. TIPS...
Abstract The lipopolysaccharide (LPS)– toll-like receptor-4 (TLR4) pathway plays an important role in liver failure. Recombinant alkaline phosphatase (recAP) deactivates LPS. aim of this study was to determine whether recAP prevents the progression acute and acute-on-chronic failure (ACLF). Eight groups rats were studied 4-weeks after sham surgery or bile duct ligation injected with saline LPS mimic ACLF. Acute induced Galactosamine-LPS both models animals treated prior administration. In...
Abstract Acute-on-chronic liver failure (ACLF) is characterized predominantly by non-apoptotic forms of hepatocyte cell death. Necroptosis a form programmed lytic death in which receptor interacting protein kinase (RIPK) 1, RIPK3 and phosphorylated mixed lineage domain-like (pMLKL) are key components. This study was performed to determine the role RIPK1 mediated ACLF. plasma levels hepatic expression RIPK1, RIPK3, pMLKL were measured healthy volunteers, stable patients with cirrhosis,...
Summary Background Loss of skeletal muscle mass is a recognised complication with prognostic impact in patients cirrhosis. Aim To explore retrospective analysis which compartment most reliably predicts the occurrence cirrhosis‐associated complications and if there are gender‐related differences. Methods 795 cirrhosis listed for liver transplantation between 2001 2014 met inclusion exclusion criteria including an abdominal CT scan (±200). Controls were 109 who underwent after polytrauma. The...
Intestinal microbiota regulates multiple host metabolic and immunological processes. Consequently, any difference in its qualitative quantitative composition is susceptible to exert significant effects, particular along the gut-liver axis. Indeed, recent findings suggest that such changes modulate severity evolution of a wide spectrum hepatobiliary disorders. However, mechanisms linking intestinal pathogenesis liver disease remain largely unknown. In this work, we investigated how distinct...
Introduction Immune cells play crucial roles in the development of chronic hepatitis B virus (HBV) infection, leading to cirrhosis and hepatocellular carcinoma (HCC). However, their functions at different disease stages are not fully understood. Methods In this study, we used single-cell RNA sequencing (scRNA-seq) characterize human liver immune microenvironment stages. We analyzed scRNA-seq data from 118,455 obtained livers six healthy individuals, four patients with HBV five cirrhosis,...
ABSTRACT Aim Cirrhotic cardiomyopathy is characterised by myocardial dysfunction in patients with cirrhosis the absence of other cardiac conditions. We aimed to develop and validate a scoring system identify at high risk for reduced global longitudinal strain, newly proposed marker updated diagnostic criteria cirrhotic cardiomyopathy. Methods Prospectively recruited training validation groups underwent identical hepatological cardiological evaluations, including strain echocardiography. Risk...
Increasing the availability of suitable organs is essential for life-saving transplant surgery. We highlight importance consent to deceased organ donation and discuss whether a ‘blanket ban’ on attaching conditions appropriate by analysing relevant legal, ethical, clinical considerations. The introduction highlights key issues in this area defines different kinds conditional donations. focus that seek limit ‘who’ might receive an organ. article outlines current approach attached organs....