A5100428737- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Sesquiterpenes and Asteraceae Studies
- Traditional Chinese Medicine Analysis
- Biological Activity of Diterpenoids and Biflavonoids
- Metabolomics and Mass Spectrometry Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Phytochemical compounds biological activities
- Bioactive Natural Diterpenoids Research
- Traditional and Medicinal Uses of Annonaceae
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Phytochemistry and Bioactive Compounds
- Alkaloids: synthesis and pharmacology
- Chromatography in Natural Products
- Plant Toxicity and Pharmacological Properties
- Ginseng Biological Effects and Applications
- Marine Sponges and Natural Products
- Phytochemical Studies and Bioactivities
- Synthesis of Organic Compounds
- Plant-derived Lignans Synthesis and Bioactivity
- Chemical synthesis and alkaloids
- Berberine and alkaloids research
- Computational Drug Discovery Methods
Shanghai University of Traditional Chinese Medicine
2016-2025
Second Military Medical University
2016-2025
Shanghai Jiao Tong University
2015-2025
Henan Normal University
2023-2025
First Affiliated Hospital of Wannan Medical College
2020-2025
Chinese Academy of Sciences
2013-2025
Northeast Agricultural University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2025
Macau University of Science and Technology
2025
Tianjin First Center Hospital
2009-2025
Inhibiting vascular endothelial growth factor (VEGF) function can improve the efficacy of immunotherapy by modulating tumor immune microenvironment. AK112 is first-in-class humanized IgG1 bispecific antibody targeting programmed death-1 (PD-1) and VEGF. This study aimed to evaluate safety combined with chemotherapy in patients advanced non-small cell lung cancer (NSCLC).This open-label, multicenter, phase II clinical trial was conducted 11 hospitals China. Eligible participants were adults...
Hydrolysis of common membrane phospholipids occurs in response to various environmental stresses, but the control and cellular function this hydrolysis are not fully understood. Hydrogen peroxide (H2O2) is a pivotal signaling molecule involved stress responses. Here, we show that plasma membrane–bound phospholipase D, PLDδ, activated H2O2 resulting phosphatidic acid (PA) functions decrease H2O2-promoted programmed cell death. The Arabidopsis genome has 12 PLD genes, knockout PLDδ abolishes...
To target complex, multi-factorial diseases more effectively, there has been an emerging trend of multi-target drug development based on network biology, as well increasing interest in traditional Chinese medicine (TCM) that applies a holistic treatment to diseases. Thousands years' clinic practices TCM have accumulated considerable number formulae exhibit reliable vivo efficacy and safety. However, the molecular mechanisms responsible for their therapeutic effectiveness are still unclear....
Network pharmacology is becoming a cutting-edge research field in current drug discovery and development thanks to rapid progress systems biology, network chemical biology. By integrating reductionist approaches as well computational experimental methods, has great potential act the next generation mode of research. studies emphasize paradigm shift from “one target, one drug” “network multicomponent therapeutics,” highlighting holistic thinking also shared by traditional Chinese medicine...
Abstract In this study, we identified a novel circRNA, circ_0002483, and further investigated its functions in the progression Taxol resistance of NSCLC. We found that circ_0002483 was expressed at low levels NSCLC tissues cell lines. Functional assays indicated overexpression significantly inhibited proliferation invasion vitro vivo enhanced sensitivity cells to Taxol. Mechanistically, sponge multiple miRNAs including miR-182-5p (also named miR-182), miR-520q-3p, miR-582-3p, miR-587,...
Significance The Wnt (wingless)/β-catenin signaling pathway is an attractive target for cancer therapy. However, known inhibitors are still far from clinical use. Here we report that the clinically approved drug axitinib strongly inhibits Wnt/β-catenin in vitro and vivo. In particular, a phenotype of inhibition called “Wnt asymmetry” was revealed axitinib-treated cells. identification E3 ubiquitin ligase SHPRH (SNF2, histone-linker, PHD RING finger domain-containing helicase) as functional...
Abstract Traditional Chinese medicines (TCMs) have important therapeutic value in long-term clinical practice. However, because TCMs contain diverse ingredients and complex effects on the human body, molecular mechanisms of are poorly understood. In this work, we determined gene expression profiles cells response to TCM components investigate activities at cellular levels. MCF7 were separately treated with 102 different molecules from TCMs, their compared Connectivity Map (CMAP). To...