A5108055751- Cardiac Fibrosis and Remodeling
- Geotechnical Engineering and Soil Stabilization
- Geotechnical Engineering and Underground Structures
- Geotechnical Engineering and Analysis
- Ferroptosis and cancer prognosis
- Magnetic and Electromagnetic Effects
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Insect-Plant Interactions and Control
- RNA Research and Splicing
- Fibroblast Growth Factor Research
- Peptidase Inhibition and Analysis
- Atrial Fibrillation Management and Outcomes
- Proteoglycans and glycosaminoglycans research
- Global trade and economics
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Pregnancy and preeclampsia studies
- Research on scale insects
- Reproductive System and Pregnancy
- Computational Drug Discovery Methods
- Plant Stress Responses and Tolerance
- Lung Cancer Treatments and Mutations
- Flavonoids in Medical Research
- MicroRNA in disease regulation
Tianjin First Center Hospital
2009-2025
Tianjin Medical University
2018-2025
Shandong University
2010-2024
Shandong Provincial Hospital
2016-2024
Xi'an University of Technology
2022-2024
Renmin Hospital of Wuhan University
2004-2023
Wuhan University
2004-2023
Nankai University
2021-2022
National Natural Science Foundation of China
2020
Shandong Transportation Research Institute
2019
Abstract In this study, we identified a novel circRNA, circ_0002483, and further investigated its functions in the progression Taxol resistance of NSCLC. We found that circ_0002483 was expressed at low levels NSCLC tissues cell lines. Functional assays indicated overexpression significantly inhibited proliferation invasion vitro vivo enhanced sensitivity cells to Taxol. Mechanistically, sponge multiple miRNAs including miR-182-5p (also named miR-182), miR-520q-3p, miR-582-3p, miR-587,...
Objectives: To observe levels of matrix metalloproteinase (MMP)-9 and evaluate their significance in various stages idiopathic atrial fibrillation (AF). Methods: Patients with AF were recruited into this prospective study classified one three groups according to stage disease progression: paroxysmal AF; persistent permanent AF. Healthy individuals enrolled as control subjects. Serum MMP-9 all four determined using a double-antibody sandwich enzyme-linked immunosorbent assay. Results: Each...
Peptidyl‑prolyl cis/trans isomerase, NIMA-interacting 1 (Pin1) is a member of large superfamily phosphorylation‑dependent peptidyl‑prolyl isomerases, which not only regulates multiple targets at various stages cellular processes, but also involved in the pathogenesis several diseases, including microbial infection, cancer, asthma and Alzheimer's disease. However, role Pin1 cardiac fibrosis remains to be fully elucidated. The present study investigated potential mechanism isoprenaline...
Circular RNAs (circRNAs) are single‐stranded which form a covalently closed continuous loop. Although originally shown to be non‐protein‐coding, some circRNAs can give rise micropeptides. have also been play essential regulatory roles in variety of developmental and disease processes. In previous study, hsa_circ_0030998 was identified as circRNA downregulated lung cancer, but its potential implications mechanisms cancer were not addressed. Here, we showed that overexpressing circ_0030998...
Despite advancements in immunotherapy, particularly regarding programmed cell death protein 1 (PD‑1)/programmed death‑ligand blockades, the clinical outcomes non‑small lung cancer (NSCLC) remain variable with limited predictive biomarkers currently available. The present study investigated respiratory microbiota diversity as a potential biomarker to predict efficacy of PD‑1 blockades patients advanced NSCLC. A retrospective analysis was conducted on 60 treated from May 2019 2023. Clinical...
Journal Article Chlorophyll Content and Fluorescence in Tomato Leaves Infested With an Invasive Mealybug, Phenacoccus solenopsis (Hemiptera: Pseudococcidae) Get access Jun Huang, Huang 1Flower Research Development Centre, Zhejiang Academy of Agricultural Sciences, Hangzhou 311202, P. R. China. Search for other works by this author on: Oxford Academic PubMed Google Scholar Peng-Jun Zhang, Zhang 3Lab Horticultural Pest, Institute Plant Protection Microbiology, 310021, Juan Yao-Bin Lu, Lu 2...
The aim of this study was to investigate the interrelation between basic fibroblast growth factor (bFGF), hepatocyte (HGF) and atrial fibrosis in patients with fibrillation (AF) rheumatic heart disease (RHD), explore possible molecular mechanisms underlying interrelation. Twenty RHD who were scheduled for valve replacement divided into two groups, comprising 10 cases AF sinus rhythm (SR). Clinical data collected a small sample aseptic left appendage by surgeon. Hematoxylin eosin (H&E)...
Purpose: This study aims to investigate the biological effect and molecular mechanism of Lamin B1(LMNB1) in lung cancer cells its significance for prognosis adenocarcinoma(LUAD) patients. Methods: In this study, Bioinformatics was performed analyze expression at mRNA level LMNB1 LUAD from TCGA dataset. The immunohistochemistry(IHC) assay conducted analyzed protein tissues. correlation between clinical factors patients with analyzed. Next, transfected into cell lines (A549 PC-9) which proved...
To investigate the role of long noncoding RNA taurine-upregulated gene 1 (TUG1) on ovarian cancer-induced angiogenesis and to explore possible signaling pathways. Ovarian cancer cell line SKOV3 or CAOV3 was transfected with short hairpin-TUG1 suppress TUG1 expression. Supernatant from cultured cells used as a condition medium incubate endothelial human umbilical vein cells, whose proliferation rate quantified by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Migration...
Abstract Objective: Apatinib mesylate is a novel vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitor, which has exhibited good safety and efficacy in several types of solid tumors. The present study aimed to assess the clinical apatinib combined with chemotherapy concurrent chemo-brachytherapy (CCBT) patients recurrent advanced cervical cancer. Methods: A total 52 first diagnosed or untreated International Federation Gynecology Obstetrics stage IVB cancer admitted at Shandong...
Freshwater resources in arid areas are scarce, while there abundant brackish water reserves that have great application potential for the irrigation of desert plants. However, will lead to soil salinization, which inhibit plant growth. Magnetized is a new technology makes use feasible. The present study assessed effects using three types (fresh, brackish, and magnetized water) five amounts (W1, 81 mm; W2, 108 W3, 135 W4, 162mm; W5, 189 mm) on salinity Haloxylon ammodendron seedling Compared...
To obtain the critical collapse pressure of a circular tunnel driven by pressurized shield for purely cohesive soils, two-dimensional analysis model is presented based on limit and slip-line theories. When ratio cover depth C to diameter D equals 0.5, there are three regions, Zones I, II, III. C/D value greater than mechanism involves up four i.e., III, possibly IV. Zone II transition zone that satisfies normality condition. IV Rankine subjected influence vertical soil arching effect appears...
The regulatory mechanisms of super enhancers (SEs) and ceRNA networks in LUAD progression are not well understood. We aimed to discover the prognostic-related network regulated by SEs metastatic LUAD. RNA-seq data were extracted from Cancer Genome Atlas (TCGA) database. Differentially expressed (DE) RNAs identified edgeR. CeRNA was predicted visualized using starBase Cytoscape. H3K27ac ChIP-seq derived Gene Expression Omnibus (GEO) database, used for SE identification. Kaplan-Meier curve...
Most antiangiogenic inhibitors targeting endothelium-dependent vessels cannot inhibit tumor growth but promote invasion and metastasis in some patients. Vasculogenic mimicry (VM) employs mechanisms that differ from those used to construct vessels. Inhibiting VM may be a novel strategy against alternative vascularization. In this paper, myricetin was selected among several flavonoid compounds as an effective PAR1 antagonist. two different hepatocellular carcinoma (HCC) cell lines...
The application of ionized water to irrigation, as a new type treatment technology, can improve the spatial distribution in soil and increase utilization efficiency, which may affect microbiological processes involved nitrogen transformation alter supply capability. However, effects technology on organic mineralization are still need further research. In this study, we investigated process with four different additions: non-ionized fresh (CK), (DE), brackish (BCK), (BDE). By using short-term...
PLCD3 belongs to the phospholipase C delta group and is involved in numerous biological functions, including cell growth, programmed death, specialization. However, role of lung cancer still needs further investigation. This research aimed investigate if influences glycolytic reprogramming development through PKC-dependent Rap1 signaling pathway. study found that was increased tissues. promotes proliferation invasion cells by activating The detailed process involves triggering PKC, which...
Background. Immunotherapy represented by PD-1 blockades had become the standard of care for advanced non-small cell lung cancer (NSCLC) gradually. Unfortunately, several inhibitor-related studies excluded elderly patients with NSCLC over 75 years age, resulting in relatively limited evidence regarding efficacy and safety clinically. Objective. This study aimed to identify effectiveness blockade monotherapy among NSCLC. Methods. Elderly (≥65 years) who received from September 2018 December...
In this study, the effects of organic silicon (Si) on toxicity imidacloprid to a new invasive mealybug, Phenacoccus solenopsis (Hemiptera: Pseudococcidae), infesting Portulaca grandiflora (Caryophyllales: Portulacaceae) plants were evaluated using spotting and dipping methods under laboratory field conditions improve management strategies for mealybug. Results showed significant synergistic 0.06% Si with solution against third-instar P. nymphs adult females. However, percentage mortalities...