A5024632077- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Effects of Radiation Exposure
- Management of metastatic bone disease
- Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Head and Neck Cancer Studies
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Lung Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Bladder and Urothelial Cancer Treatments
- Colorectal and Anal Carcinomas
- Cancer, Hypoxia, and Metabolism
- BRCA gene mutations in cancer
- Endometriosis Research and Treatment
- PARP inhibition in cancer therapy
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
Beijing National Laboratory for Molecular Sciences
2021-2025
Peking University
2021-2025
Shandong Tumor Hospital
2013-2024
Shandong First Medical University
2014-2024
Shandong University
2014-2020
Academy of Medical Sciences
2020
National Natural Science Foundation of China
2020
Shandong Provincial QianFoShan Hospital
2020
Identification of novel factors critical for epithelial to mesenchymal transition (EMT) and cancer initiating cell (CIC) formation may aid in the identification therapeutics treatment endometrial cancer. The present study demonstrated that L1 adhesion molecule (CAM) is EMT CICs Overexpression L1CAM promote with increased HEC-1A cells. status resist chemotherapeutic drugs regenerate various types tumors, thereby resulting relapse disease. overexpressing promoted paclitaxel resistance...
In ovarian cancer patients, chemotherapy resistance is the principal factor restricting long-term treatment. Paclitaxel (Pac) has been previously reported to be a ligand Toll-like receptor 4 (TLR4). It was determined that TLR4 signaling divided into following two pathways: Myeloid differentiation 88 (MyD88)-dependent and MyD88-independent. The present study investigated effect of ligation by Pac in MyD88-positive (MyD88+) MyD88-negative (MyD88-) human cell lines. An RNA interference...
Remodeling spacing factor 1 (RSF-1/HBXAP) has been linked to a variety of cancer types, however, its roles and the therapeutic potential are not clear in cervical cancer.
Epithelial ovarian cancer (EOC), the sixth most common in women worldwide, is commonly fatal gynecologic malignancy developed countries. One of main reasons for this that relatively little was known about molecular events responsible development highly aggressive disease. In present study, we demonstrated salt‑inducible kinase 1 (SIK1; which also as MSK/SIK/SNF1LK) downregulated tissue samples. Using HEY cells, noted SIK1 overexpression inhibited proliferation well stem cell-associated...
Maintenance therapy (MT) for recurrent or metastatic cervical cancer remains non-standardized. This study assessed MT effectiveness using a comprehensive approach and identifies prognosis factors inpatients with cancer.
The aggregation behaviors of conjugated polymers significantly influence their performance in solution-processed optoelectrical devices. Traditionally, the formation aggregates from self-assembly is considered as a thermodynamic equilibrium process. abundant degree conformation freedom might lead to complex solution. However, energy landscape during has rarely been studied before, which would provide energetic and structural information about different aggregates. Our work tried unravel...
Patients with ovarian carcinoma are at high risk of tumor recurrence. In the present study, 81 Notch pathway genes were selected to find recurrence-related in The Cancer Genome Atlas dataset. A 10-gene signature (FZD4, HES1, PSEN2, JAG2, PPARG, FOS, HEY1, CDC16, MFNG, and EP300) was identified validated that is associated recurrence-free survival time, but not overall TCGA dataset other two independent datasets, GSE9891 GSE30161. This gene gave a significant performance discriminating...
Abstract Objective: Apatinib mesylate is a novel vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitor, which has exhibited good safety and efficacy in several types of solid tumors. The present study aimed to assess the clinical apatinib combined with chemotherapy concurrent chemo-brachytherapy (CCBT) patients recurrent advanced cervical cancer. Methods: A total 52 first diagnosed or untreated International Federation Gynecology Obstetrics stage IVB cancer admitted at Shandong...
Background Cisplatin remains the mainstay of endometrial cancer (EC) chemotherapy. Wilms’ tumor 1-associated protein (WTAP), playing a critical role in transcriptional and post-transcriptional regulation, has been reported as an oncogene, its expression is elevated multiple types human tumors. Recent evidence shown that increased WTAP also closely related to chemo-resistance. However, specific susceptibility EC cells cisplatin largely unexplored. Methods over-expression depletion cell lines...
Glutamine is one of the primary nutrients utilized by cancer cells for energy production and biosynthesis. Hence, interfering with glutamine metabolism may impose anti-tumor effects. In this study, we assessed anti-tumorigenic effects glutaminase-1 enzyme (GLS1) inhibition in endometrial vitro vivo. The human cell lines Ishikawa HEC-1B were used. compound 968 on proliferation, cycle, apoptosis, cellular stress, AKT/mTOR pathway assessed. synergistic paclitaxel also analyzed. vivo effect was...
'Triple-negative' is traditionally used to define a specific subtype of breast cancer with negative oestrogen receptor (ER), progesterone (PR) and human epidermal growth factor receptor-type 2 (HER2) expressions. ER/PR HER2 testing also widely in the informative classification ovarian cancer.To investigate whether 'triple-negative' exists cancer.ER, PR expressions 116 Chinese women primary epithelial were reviewed. Triple-negative (TNEOC) was defined based on ER, expression. The...
Abstract Background Radiation-induced pneumonitis (RP) is a non-negligible and sometimes life-threatening complication among patients with thoracic radiation. We initially aimed to ascertain the predictive value of acute radiation-induced esophagitis (SARE, grade ≥ 2) symptomatic RP (SRP, cancer receiving radiotherapy. Based on that, we established novel nomogram model provide individualized risk assessment for SRP. Methods Thoracic who were treated radiation from Jan 2018 2019 in Shandong...
Abstract Background: Recently, T-helper 17 (Th17) cells have been proved to play an important role in promoting cervical cancer. But, till now, few study has carried out understand the involvement of these efficacy anti-tumor treatments. This aimed investigate alterations percentage circulating Th17 and related cytokines locally advanced cancer (LACC) patients before after concurrent chemoradiotherapy (cCRT) analyze correlations between treatment efficacy. Methods: A prospective with 49 LACC...
Epithelioid trophoblastic tumor (ETT) is the rarest type of gestational (GTT). It has been reported that more than 50% ETTs arise in uterine cervix or lower segment. Here, we report a case ETT within segment and cervical canal discuss its manifestations, possible causes, related influencing factors.A 35-year-old woman (gravida 7, miscarriage 3, induction 2 with 1 being twins, para cesarean section, live 2), who had amenorrhea for 9 mo after breastfeeding 22 last was diagnosed ETT. The lesion...
The current study was aimed to evaluate the efficacy and toxicity of postoperative adjuvant chemotherapy (CT) combined with intracavitary brachytherapy (ICRT) in cervical cancer patients intermediate-risk.We analyzed medical records 558 who were submitted radical surgery for Stage IB-IIA cancer. A total 172 those considered intermediate-risk according GOG criteria. Among patients, 102 subjected CT ICRT (CT+ICRT) remaining 70 treated concurrent chemoradiation (CCRT). 3-year disease free...
5535 Background: Anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) and anti-programmed cell death 1 (PD-1) antibodies have synergistic effect. QL1706 is a novel dual immune checkpoint blockade containing mixture of anti-PD-1 IgG4 anti-CTLA4 IgG1 produced by single line. showed promising anti-tumor activity in multiple solid tumors. Here we reported the cervical cancer cohort data from phase 1b trial (NCT05171790). Methods: Eligible patients had pathologically confirmed diagnosis squamous...