A5101772660- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Management of metastatic bone disease
- Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Shoulder Injury and Treatment
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Thyroid and Parathyroid Surgery
- Thyroid Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Cancer Mechanisms and Therapy
- Risk Management in Financial Firms
- Intraperitoneal and Appendiceal Malignancies
- Metabolism, Diabetes, and Cancer
- PARP inhibition in cancer therapy
- Elbow and Forearm Trauma Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- GDF15 and Related Biomarkers
- Case Reports on Hematomas
- Cancer-related molecular mechanisms research
- Clostridium difficile and Clostridium perfringens research
Shandong Tumor Hospital
2011-2025
Shandong First Medical University
2011-2025
Jining Medical University
2024
Shandong University
2007-2023
Tianjin Medical University General Hospital
2021
Nanjing University
2020
Nanjing General Hospital of Nanjing Military Command
2020
Peking University
2020
Peking University Cancer Hospital
2020
Academy of Medical Sciences
2020
Aim: Cancer-associated fibroblasts (CAFs) are closely related to epithelial-mesenchymal transition (EMT) and chemoresistance in various cancers. Patients & methods: Experiments vivo retrospective studies were applied explore the role of CAFs epithelial ovarian cancer (EOC). Results: We found that CXCL12 expression was significantly increased interstitial by immunofluorescence. CAF-derived induced EMT though CXCR4/Wnt/β-catenin pathway EOC cells. Inhibited led apoptosis cisplatin sensitivity....
Abstract Background The purpose of this study was to assess the feasibility and accuracy sentinel lymph nodes (SLNs) detection using 99mTc phytate in predicting pelvic status for radical abdominal trachelectomy (RAT) patients with early stage cervical cancer. Methods Sixty-eight women IA2-IB1 cancer scheduled undergo fertility-sparing surgery enrolled study. 99mTc-labeled injected before surgery. Intraoperatively, SLNs were identified, excised, submitted fast frozen section. Systematic...
Objectives: We compared the diagnostic performance of gadoxetic acid-enhanced MRI and 16-slice multidetector CT (MDCT) with respect to their abilities detect hepatic metastases differentiate from cysts haemangiomas. Methods: 67 patients 110 liver (size 0.3–2.5 cm), 33 haemangiomas 0.5–1.5 cm) 17 0.3–1.0 underwent 4-phase MDCT MRI, including early dynamic phases, post-contrast T2 weighted turbo spin echo sequences 20 min hepatocyte-selective phases. Two observers independently analysed each...
Disordered proliferation and angiogenesis of pulmonary artery endothelial cells is an important stage in the development arterial hypertension. Recent studies revealed that GDF11 (growth differentiation factor 11) induces migration; however, whether directly involved pathogenesis hypertension remains unknown. Here, we found was significantly upregulated activated 2 experimental models cultured cells. Genetic ablation gdf11 rescued features, as demonstrated by right ventricle hypertrophy,...
To observe mRNA expression of tumor-specific antigen MAGE, BAGE and GAGE in epithelial ovarian cancer tissues cell lines, to explore the relationship between gene diagnosis, treatment prognosis cancer, evaluate feasibility their products as markers, an immunotherapy target for cancer. MAGE-1, MAGE-3, GAGE-1/2 were determined by reverse transcription polymerase chain reaction (RT-PCR) 14 cases normal tissue, 20 benign tumor specimens, 41 lines SKOV3, A2780, COC1. genes not expressed tissue....
2611 Background: BAT1308 is a fully humanized and high-affinity anti-PD-1 IgG4κ antibody. Previous phase 1 study demonstrated had promising efficacy in patients with advanced cervical cancer. Here we present the primary safety results 2 for combined platinum-based chemotherapy ± bevacizumab as first-line therapy PD-L1–positive persistent, recurrent, or metastatic Methods: In this multicenter, single-arm, open-label, study, eligible were ≥18 to ≤75 years of age PD-L1 CPS ≥1, FIGO Stage IVB...
Epithelial–mesenchymal transition (EMT) plays an important role in oncogenesis, through which cancer cells acquire invasion and metastasis capacity. Notably, the chemokine receptor CXCR7 its ligands CCL19 can also facilitate lymph node epithelial ovarian carcinomas. Here, we assumed that might be involved EMT process of In our study, activation inhibition SKOV3 were induced with exogenous small interfering RNA (CXCR7 siRNA), respectively. AKT ERK protein pathways as well biomarkers...
AimTo compare dosimetry, efficacy, and toxicity of intensity-modulated radiation therapy (IMRT) with para-aortic field radiotherapy in patients lymph node (PALN) metastasis cervical cancer.MethodsThis prospective study examined 60 cancer PALN who underwent whole-pelvis followed by brachytherapy between November 1, 2004 May 31, 2008. After 3 cycles chemotherapy, were serially allocated into two groups treated IMRT or RT at doses 58-68 Gy 45-50 Gy, respectively. Treatment response was...
BackgroundEarly integration of palliative care (PC) for patients with advanced cancer has been recommended to improve quality care. This study aims describe prevalence, temporal trend and predictors PC use in metastatic breast (mBCa) receiving critical therapies (CCT; included invasive mechanic ventilation, percutaneous endoscopic gastrostomy tube, total parenteral nutrition, tracheostomy dialysis).MethodsThe National Inpatient Sample was queried mBCa CCT between 2005 2014. Annual percent...
Objective: To evaluate the efficacy and safety of Saccharomyces boulardii in prevention antibiotic-associated diarrhea (AAD) infants young children. Method: From November 2012 to September 2013, ten research units large teaching hospitals or children's participated this multicenter randomized controlled clinical trial. Hospitalized children aged between 1 month 3 years (nongastrointestinal infection antibiotic therapy required)were involved our study. The were randomly divided into control...
To investigate the impact of postoperative adjuvant therapy on survival patients with intermediate risk early-stage cervical squamous cell carcinoma.A total 133 consecutive carcinoma treated at Shandong Cancer Hospital and Institute from February 2010 to March 2014 were enrolled in our study. All received subdivided into three groups: pelvic radiotherapy (RT; N=42), chemotherapy + intracavitary (CT+ICRT; N=47), or concurrent chemoradiation (CCRT; N=44). Disease-free (DFS) therapeutic...
Multiple morphological changes in two or more sites of concurrent multifocal mucinous lesions the female genital tract are indicative SMMN-FGT, which is unrelated to high-risk HPV infection. MUC6 and HIK-1083 showed positive characteristic immunohistochemistry. Seldom condition described. Here we describe an SMMN-FGT patient who also had lung metastases STK11/KRAS gene mutations. Based on current researches, hypothesize that closely associated with development cervical gastric adenocarcinoma.
The current study was aimed to evaluate the efficacy and toxicity of postoperative adjuvant chemotherapy (CT) combined with intracavitary brachytherapy (ICRT) in cervical cancer patients intermediate-risk.We analyzed medical records 558 who were submitted radical surgery for Stage IB-IIA cancer. A total 172 those considered intermediate-risk according GOG criteria. Among patients, 102 subjected CT ICRT (CT+ICRT) remaining 70 treated concurrent chemoradiation (CCRT). 3-year disease free...
Background: Ultrasound-guided fine-needle aspiration (FNA) cytology is a crucial diagnostic technique used to assess thyroid nodules. In the past, ultrasound-guided FNA was performed mainly by radiologists. However, many surgeons are increasingly being trained for this procedure now. study, we aimed compare adequacy and efficiency of newly head neck with experienced radiologists in single institution. We also assessed malignancy rates nondiagnostic nodules differences between benign...
We aimed to compare the efficacy of paclitaxel and carboplatin followed by gemcitabine-based combination chemotherapy with paclitaxel–carboplatin for treating advanced epithelial ovarian cancer in this retrospective, STROBE-compliant study. Patients’ tolerance treatment was also assessed. retrospectively analyzed records 178 women who underwent initial optimal debulking surgery between January 2003 December 2011 treat FIGO stage IIIc cancer. Patients arm 1 (n = 88) received 4 cycles 2...