A5074903549- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Circadian rhythm and melatonin
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Neonatal and Maternal Infections
- Gut microbiota and health
- Diagnosis and treatment of tuberculosis
- Helicobacter pylori-related gastroenterology studies
- Streptococcal Infections and Treatments
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Bacterial Infections and Vaccines
- Gastroesophageal reflux and treatments
- Drug-Induced Hepatotoxicity and Protection
- Clostridium difficile and Clostridium perfringens research
- Sepsis Diagnosis and Treatment
- Spaceflight effects on biology
- Antimicrobial Resistance in Staphylococcus
- Immunodeficiency and Autoimmune Disorders
- Clinical Nutrition and Gastroenterology
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Congenital Diaphragmatic Hernia Studies
Sichuan University
2015-2024
West China Second University Hospital of Sichuan University
2015-2024
Ministry of Education of the People's Republic of China
2016-2024
National Health and Family Planning Commission
2024
West China Medical Center of Sichuan University
1992-2023
Chengdu Women's and Children's Central Hospital
2018-2023
Saskatoon Medical Imaging
2023
Toko University
2016
Chengdu Fifth People's Hospital
2009
State Key Laboratory of Biotherapy
2006-2007
Japanese encephalitis is a major cause of death and disability throughout Asia, including the Indian subcontinent. Although an effective vaccine for available, hundreds millions susceptible individuals remain unimmunised because vaccine's cost. In 1988, inexpensive live-attenuated (SA14-14-2) was licensed in China. We have measured effectiveness this vaccine.In case-control study rural Sichuan Province, China, 56 cases consisted children admitted to hospital with acute encephalitis, were...
The Period2 gene, an indispensable component of the circadian clock, not only modulates oscillations, but also regulates organic function. We examined whether overexpression mouse gene (mPer2) in tumor cells influences cell growth and induces apoptosis. Overexpression PERIOD2 Lewis lung carcinoma line (LLC) mammary (EMT6) results reduced cellular proliferation rapid apoptosis, NIH 3T3 cells. Overexpressed mPER2 altered expression apoptosis-related genes. mRNA protein levels c-Myc, Bcl-X(L)...
Aim To evaluate the efficacy of probiotics in treatment adult and childhood non‐alcoholic fatty liver disease (NAFLD). Methods Randomized controlled trials on NAFLD published before July 2015 were searched multiple databases, including Cochrane Library, PubMed/MEDLINE, EBSCO, OVID, SCI, CNKI, VIP. Article identification data extraction carried out by two reviewers based inclusion exclusion criteria. RevMan 5.3 software was used for meta‐analysis. Results Nine randomized with a total 535...
Abstract Background Gut microbiota plays a critical role in many important physiological processes and is linked with various pulmonary infectious diseases. The relationship between tuberculosis (PTB) gut has been poorly studied. present study aimed to characterize pediatric patients PTB. Methods A case-controlled was executed for the characterization of PTB patients. Fecal samples were collected from healthy controls upon admission. In addition, one-month follow-up assessment performed...
The short-term safety of an effective and inexpensive new live attenuated Japanese encephalitis vaccine (SA14-14-2) was studied in a randomized trial, using block randomization. Of 26,239 children who were enrolled, half received the served as controls. Subjects prospectively followed for 30 days severe adverse events, such encephalitis, meningitis, “all-cause” hospitalization. No cases or meningitis occurred either group. upper 95% confidence limit events not occurring among subjects...
Gut microbes have been suggested as the possible targets in management of allergic diseases. However, way which these influence diseases remain unclear. Forty-seven full-term newborns were selected from a 1000-infant birth cohort. Among them 23 infants, whereas 24 infants healthy without symptoms at 1 year age. Two hundred and sixty-four fecal samples collected 7 time points following their birth. These microbiologically analyzed using 16S rRNA gene sequencing. The dynamic processes involved...
The number of antibiotics that are appropriate for Helicobacter pylori eradication in children is limited. Profiling regional or population-specific antibiotic resistance essential guiding the H. treatment children. aim this study was to evaluate strains isolated from and adolescents Southwest China. Gastric biopsies 157 pediatric patients with without previous were collected culture. Susceptibility amoxicillin (AML), clarithromycin (CLR), metronidazole (MTZ), levofloxacin (LEV),...
Background Staphylococcus aureus is commonly carried asymptomatically in the human anterior nares and occasionally enters bloodstream to cause invasive disease. Much of global diversity S. remains uncharacterised, not clear how disease propensity varies between strains, host populations. Methodology We compared 147 isolates recovered from five kindergartens Chengdu, China, with 51 contemporaneously cases pediatric infection main hospital serving this community. The samples were characterised...
This study examined the association between hypertension and AD by using a quantitative meta-analysis of longitudinal studies. EMBASE MEDLINE were searched for articles published up to February 2011. All studies that h
In recent years, the impact of Helicobacter pylori (H pylori) on gut microbiota has attracted more attention; however, relationship in pediatric population rarely was reported.Endoscopic gastric mucosal biopsy specimens from 55 children with gastrointestinal symptoms were collected, 37 them H pylori-positive (23 nonpeptic ulcer and 14 peptic ulcer) 18 pylori-negative. addition, 11 collected who performed second endoscopy 4 weeks after therapy. Microbial abundance compositions analyzed by 16S...
Recent studies have demonstrated that antibiotics/or probiotics administration in early life play key roles on modulating intestinal microbiota and the alterations might cause long-lasting consequences both physiologically immunologically. We investigated effects of ceftriaxone, vancomycin Bifidobacterium bifidum TMC3115 (TMC3115) treatment immunity neonates adults even after termination antibiotics exposure. found ceftriaxone vancomycin, but not TMC3115, significantly altered microbiota,...
Abstract The hepatic vascular niche plays an important role in the pathological process of liver fibrosis. Liver sinusoidal endothelial cells (LSECs) predominantly compose niches. Endothelial cell (EC)‐expressing sphingosine 1‐phosphate receptor 2 (S1pr2) essential regulation functions. Nevertheless, it remains unknown whether LSEC‐S1pr2 might modulate In this study, fibrosis was induced by hepatotoxin carbon tetrachloride (CCl 4 ). expression S1pr2 is significantly downregulated after CCl...