Xiaohong Xu
A5113291655- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Obesity, Physical Activity, Diet
- Fatty Acid Research and Health
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- MicroRNA in disease regulation
- Nutritional Studies and Diet
Second Affiliated Hospital of Zhejiang University
2024
Capital Medical University
2020-2023
Beijing Obstetrics and Gynecology Hospital
2020-2023
<div>Abstract<p>In patients with non–small cell lung cancer (NSCLC), the relationship between tumor metabolism and clinical outcomes is unknown. Here, <sup>13</sup>C-labeled nutrients were intraoperatively infused into more than 90 surgically resectable pulmonary lesions, metabolic properties of resected tumors correlated survival. In NSCLCs <sup>13</sup>C-glucose, high <sup>13</sup>C enrichment in tricarboxylic acid (TCA) cycle intermediates...
<p>(Related to Figure 1). TCA cycle labeling and metabolite abundance in tumors lungs from NSCLC patents.</p>
<p>(Related to Figure 3). TCA cycle metabolite abundance does not correlate with overall survival.</p>
<p>Inhibition of complex I with IACS-010759 limits metastasis in NSCLC PDXs. <b>A</b> and <b>B,</b> Tumor-bearing mice were treated daily DMSO or (5 mg/kg) by oral gavage for 3–4 weeks then infused [U-<sup>13</sup>C]glucose 3 hours. Overall TCA cycle enrichment was calculated as the sum isotopologues citrate, malate, glutamate compared between DMSO- IACS-010759–treated groups. <b>C</b> <b>D,</b> Subcutaneous tumor volume (L ×...
<p>(Related to Figure 2). Epithelial and myeloid cell contributions gene expression 13C labeling features.</p>
<p>(Related to Figures 5 and 6): Treatment with IACS-010759 reduces distant metastasis.</p>
<p><sup>13</sup>C enrichment in the TCA cycle distinguishes tumors but not benign pulmonary lesions from adjacent lung. <b>A,</b> Summary of patients with lesions. <b>B,</b> Schematic labeling [U-<sup>13</sup>C]glucose, including glycolysis and multiple turns cycle. <b>C–E,</b><sup>13</sup>C comparisons between each lesion type The sum isotopologues metabolite is normalized to corresponding Each dot represents one...
Obesity has been linked to various detrimental health consequences. While there is established evidence of a negative correlation between seafood consumption and obesity in adults, the current research on association intake childhood/adolescence risk lacking. Our aim was evaluate Chinese nationwide cohort.
Objectives: Ovarian cancer is the most lethal gynecologic malignancy, and targeted therapy for different pathological types molecular phenotypes urgent to be studied. Studies have shown that MicroRNA-592 (miR-592) plays an important negative regulatory role in occurrence of gastrointestinal malignancies, breast cancer, non-small cell lung glioma, but expression miR-592 ovarian mechanism action are still unclear. Methods: The expressions were examined by RT-PCR Western Blot. Cell viability...
Abstract BACKGROUND: Data on the survival outcome between laparoscopic and open abdominal radical hysterectomy is limited in patients with endometrial cancer involving cervix. METHODS: We performed a retrospective 1:1 matched observational study who had their cervix involved by during 2010–2018 period Beijing Obstetrics Gynecology Hospital China. All enrolled underwent cancer-directed through approach or surgery followed until 3 years after surgery. The primary was rates of disease-free...