A5100404828- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Caveolin-1 and cellular processes
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Metabolism, Diabetes, and Cancer
- Immune cells in cancer
- Diamond and Carbon-based Materials Research
- Signaling Pathways in Disease
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
- MRI in cancer diagnosis
- Radiation Therapy and Dosimetry
- Immunotherapy and Immune Responses
- Breast Cancer Treatment Studies
- Colorectal Cancer Treatments and Studies
- Melanoma and MAPK Pathways
- Ovarian cancer diagnosis and treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cell Adhesion Molecules Research
Anyang Tumor Hospital
2024
Handan College
2024
Fudan University Shanghai Cancer Center
2016-2022
Shanghai Medical College of Fudan University
2022
Chongqing Cancer Hospital
2021
Chongqing University
2021
Ministry of Education of the People's Republic of China
2014
Central South University
2014
Our previous study reported that microRNA-26a (miR-26a) inhibited tumor progression by inhibiting angiogenesis and intratumoral macrophage infiltration in hepatocellular carcinoma (HCC). The direct roles of miR-26a on cell invasion remain poorly understood. In this study, we aim to explore the mechanism modulating epithelial-mesenchymal transition (EMT) HCC. vitro morphology migration were compared between hepatoma lines HCCLM3 HepG2, which established study. Overexpression down-regulation...
MicroRNA-221/222 (miRNA-221/222, miR-221/222) is a noncoding microRNA which widely distributed in eukaryotic organisms and deeply involved the posttranscriptional regulation of gene expressions. According to recent studies, abnormal expressions miR-221/222 are closely related occurrence development various kinds malignant tumors. The role tumor their potential molecular mechanism cancers, including liver cancer, colorectal cervical ovarian endometrial carcinoma, summarized reviewed this...
Background Radiofrequency ablation (RFA) is one of the curative therapies for hepatocellular carcinoma (HCC), however, accelerated progression residual HCC after incomplete RFA has been reported more frequently. The underlying molecular mechanism this phenomenon remains to be elucidated. In study, we used an orthotopic nude mouse model study invasive and metastatic potential cancer as well correlated mechanism. Methods models were established using high cell line HCCLM3 low HepG2,...
Monoacylglycerol lipase (MAGL), a critical lipolytic enzyme, has emerged as key regulator of tumor progression, yet its biological function and clinical significance in hepatocellular carcinoma (HCC) is still unknown. In this study, we used tissue microarray containing samples from 170 HCC patients to evaluate the expression MAGL correlation with other clinicopathologic characteristics. addition, investigated regulating effects on various lines. Finally, identified NF-κB signaling pathway...
Radiofrequency ablation (RFA) therapy has proven to be effective and feasible for early-stage hepatocellular carcinoma (HCC); however, rapid progression of residual tumor cells after RFA been confirmed, but the molecular mechanisms this phenomenon are poorly understood. This study evaluated effect lipid raft proteins known as flotillins on invasive metastatic potential HCC.The human HCC cell line HCCLM3 was used establish insufficient models in vivo vitro. Changes cellular morphology, soft...
The profile of microRNAs (miRNAs) altered following middle cerebral artery occlusion (MCAO) and miRNAs are involved in angiogenesis ischemia. miR‑376b‑5p was decreased MCAO, however, whether is important remains to be elucidated. present study designed identify ischemia elucidate the underlying mechanisms. A rat MCAO model established quantitative polymerase chain reaction performed analyze mRNA expression level for 1 7 days. In addition, density microvessels relative protein levels...
BACKGROUND:CD81, a member of the tetraspanin family, is overexpressed in several tumor types, but its role breast cancer remains unknown. The present study aimed to investigate effects increased CD81 expression on cell migration and proliferation lines, MDA-MB-231 MDA-MB-435S vitro, tissue microarrays patient prognosis. MATERIAL AND METHODS:The was evaluated using immunohistochemistry human microarray containing 140 tissues 77 normal tissues. MDA-MB-435S, were by proliferation, transwell...
The field of biomedical research has recently been interested in nanoplatforms with various functionalities, such as cancer drug carriers and MRI optical imaging, well thermal treatment, among other things. As a result the present investigation, unique multifunctional liposome (MFL) was established this investigation. Using radiofrequency-induced imaging release based on magnetic impact, dual delivery targeted tumor multi-mechanism treatment made more effective. C60 (fullerene) surface...
Pulmonary tuberculosis (TB) is a chronic infectious disease that caused by respiratory infections, principally Mycobacterium tuberculosis. Increasingly, studies have shown circular (circ)RNAs play regulatory roles in different diseases through mechanisms. However, their and potential mechanisms pulmonary TB remain unclear. In this study, we analyzed circRNA sequencing data from adjacent normal diseased tissues patients the differentially expressed genes. We then constructed machine learning...
Abstract Metastasis and recurrence contribute to poor prognosis of hepatocellular carcinoma (HCC). Recently, we reported that interferon-α (IFN-α) can suppress metastasis HCC; however, the underlying mechanism has not been fully described. In this study, demonstrated expression dihydropyrimidine dehydrogenase (DPYD), a pyrimidine catabolic enzyme, was dose-dependently downregulated by IFN-α in HCC tissues from nude mice. Notably, DPYD found be significantly increased cell lines with higher...
This study investigated the function and molecular mechanisms of miR-744-5p in multiple myeloma (MM).miR-744-5p SRY-related high-mobility-group box 12 (SOX12) expression clinical tissues MM cells was monitored by quantitative real-time polymerase chain reactions Western blot. regulated transfection. Cell proliferation researched cell counting kit-8 assay plate clone formation experiment. Transwell experiment utilized for migration invasion detection. Glycolysis test conducted detection...
Objectives: Ovarian cancer is the most lethal gynecologic malignancy, and targeted therapy for different pathological types molecular phenotypes urgent to be studied. Studies have shown that MicroRNA-592 (miR-592) plays an important negative regulatory role in occurrence of gastrointestinal malignancies, breast cancer, non-small cell lung glioma, but expression miR-592 ovarian mechanism action are still unclear. Methods: The expressions were examined by RT-PCR Western Blot. Cell viability...
Breast cancer has become one of the main diseases threatening women's health and lives. Ultrasound (US) is first diagnostic option for several patients because its non-radiation, convenient, low-cost features. Conventional US combined with contrast-enhanced (CEUS) improved accuracy, while due to presence numerous parameters, no international consensus on criteria could be attained. Therefore, it necessary develop a reliable model involvement few parameters increasing accuracy.
In order to assess the metastatic potential of residual hepatocellular carcinoma (HCC) following insufficient radiofrequency ablation (RFA) and improve current animal model, an RFA orthotopic nude mouse model HCC was developed in present study. A human established using HCCLM3 cells, which has a high potential, labeled with green fluorescent protein. total 12 mice within group received control needle electrode puncture tumor without ablation, 3 weeks after implantation. To investigate growth...
Purpose The aim of this study is to investigate the value total laparoscopic simultaneous colorectal and hepatic resection in patients with synchronous cancer liver metastases (sCRLMs). Methods sCRLM who underwent from December 2014 2018 Shanghai Cancer Center, Fudan University were recruited analyzed retrospectively. divided into laparoscopic, open, hybrid surgery groups. intraoperative information, postoperative short-term outcome, long-term survival compared among three Propensity score...
IL-8 over-expression could enhance cancer metastasis. In present study, berberine hydrochloride (BER) triggered proliferative inhibition and G2/M arrest in AGS cells, down-regulated protein expression of cyclin B1, Bcl-2, up-regulated p21, p53 cleaved caspase 3, but showed no effect on CHOP, Bip, 4. BER down-regulate the enhanced through down-regulating ERK1/2 p38 MAPK over-activation induced by SN 38. The increased mediated adhesive ability cells to HUVECs 38, be reduced BER. Thus, reduce...