A5101523693- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Endometriosis Research and Treatment
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Mesenchymal stem cell research
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- Macrophage Migration Inhibitory Factor
- Immune Cell Function and Interaction
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Galectins and Cancer Biology
- RNA Research and Splicing
- Retinoids in leukemia and cellular processes
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Inflammasome and immune disorders
Dalian University of Technology
2025
Wuhan Institute of Technology
2025
Fudan University
2009-2024
Zhongshan Hospital
2009-2024
Sun Yat-sen Memorial Hospital
2021-2024
Sun Yat-sen University
2009-2024
Fudan University Shanghai Cancer Center
2016-2024
Tianjin Medical University General Hospital
2017-2023
Shanghai Medical College of Fudan University
2019-2023
Anhui Medical University
2019-2023
Macrophages are a major component of the leukocyte infiltrate tumors and play pivotal role in progression hepatocellular carcinoma (HCC). However, molecular mechanisms by which macrophages promote HCC invasion poorly understood. The present study was undertaken to investigate relationship between epithelial-mesenchymal transition (EMT) HCC. Double-staining immunohistochemistry used observe association EMT markers clinical samples it showed that primarily occurred at edge tumor nest,...
N6-methyladenosine (m6A) RNA modification, a dynamic and reversible process, is essential for tissue development pathogenesis. However, the potential involvement of m6A in regulation cardiomyocyte (CM) proliferation cardiac regeneration remains unclear. In this study, we aimed to investigate role modification heart during postnatal adult injury. Methods results: identified downregulation demethylase ALKBH5, an "eraser" that responsible increased methylation, after birth. Notably, ALKBH5...
PML-RARα oncoprotein is a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-α (RARα) causes acute leukemias (APL). A hallmark all-trans (ATRA) responses in APL degradation which promotes cell differentiation. Here, we demonstrated that autophagy crucial regulator degradation. Inhibition by short hairpin (sh) RNA target essential genes such as Atg1, Atg5 PI3KC3 inhibitors (e.g. 3-methyladenine), blocked subsequently granulocytic differentiation human myeloid...
To investigate the expression of metadherin (MTDH) for its prognostic value in hepatocellular carcinoma (HCC) and role promoting HCC metastasis.This study employed a tissue microarray containing samples from 323 patients to examine MTDH correlation with other clinicopathologic characteristics. The regulation metastasis was investigated both vitro vivo using short hairpin RNA (shRNA)-mediated downregulation cell lines various metastatic potentials.The markedly higher tumors than normal liver...
Endothelial cells (ECs) are critical for angiogenesis, and microRNAs play important roles in this process. We investigated the regulatory role of ECs hepatocellular carcinoma (HCC) by examining microRNA expression profile human umbilical vein endothelial (HUVECs) absence or presence HCC cells, identified miR-146a as most highly upregulated microRNA. Furthermore, we revealed that promoted platelet-derived growth factor receptor α (PDGFRA) HUVECs, process was mediated BRCA1. Overexpression...
Our previous study reported that microRNA-26a (miR-26a) inhibited tumor progression by inhibiting angiogenesis and intratumoral macrophage infiltration in hepatocellular carcinoma (HCC). The direct roles of miR-26a on cell invasion remain poorly understood. In this study, we aim to explore the mechanism modulating epithelial-mesenchymal transition (EMT) HCC. vitro morphology migration were compared between hepatoma lines HCCLM3 HepG2, which established study. Overexpression down-regulation...
Expression of heterogeneous nuclear ribonucleoprotein AB (HNRNPAB) has been reported to be dysregulated in tumors, but its specific contributions tumor formation and progression are not fully understood. Here, we demonstrate that HNRNPAB is overexpressed highly metastatic cells tissues from patients with hepatocellular carcinoma (HCC) recurrence. We found overexpression promoted epithelial-mesenchymal transition (EMT) a manner associated HCC metastasis vitro vivo. RNA interference-mediated...
Exosomes are important mediators of intercellular communication and have a vital part in the diagnosis treatment various diseases humans. Here, we investigated benefits underlying mechanism exosomes secreted via stem cells from human exfoliated deciduous teeth (SHED-derived exosomes) promoting alveolar bone regeneration, thus providing new insights into exosome-based therapy for periodontitis. SHED-derived were isolated by ultracentrifugation. The impacts on angiogenic ability umbilical vein...
Driven by the principles of green consumption and social responsibility, more companies are making strategic investments adopting blockchain technology to achieve sustainable development goals. However, in real market, upstream manufacturers often tend be overconfident. This can have a significant impact on decision-making processes even influence other members within supply chain. paper investigates investment decisions chains for manufacturer exhibiting overconfidence. We construct chain...
Breast milk samples and 24-hour food records were obtained from lactating mothers on day 1 (colostrum), 14 (transitional milk) 42 (mature Hangzhou (n = 202), Lanzhou 133) Beijing 142), China. Fatty acid methyl esters prepared by standard methods, separated quantified gas chromatography. We aimed to investigate the fatty composition (% of total acid) in human three stages regions China relationship with maternal dietary intake during lactation. Present results showed that breast varied period...
Long terminal repeat (LTR) retrotransposons are a major class of transposable elements, accounting for 8.67% the human genome. LTRs can serve as regulatory sequences and drive transcription tissue or cancer-specific transcripts. However, role these LTR-activated transcripts, especially long non-coding RNAs (lncRNA), in cancer development remains largely unexplored. Here, we identified novel lncRNA derived from MER52A (lncMER52A) that was exclusively expressed hepatocellular carcinoma (HCC)....
The combination of immunotherapy with platinum-based chemotherapy has become the first-line treatment for patients advanced non-small cell lung cancer (NSCLC) negative driver gene mutations. However, finding an ideal chemotherapeutic regimen and exploring underlying mechanism have noticeably attracted clinicians' attention. In this study, we found that cisplatin induced ferroptosis tumor cells, followed by N1 neutrophil polarization in microenvironment, which turn remodeled "cold" to a "hot"...
Damage-associated molecular pattern molecules (DAMPs) are cellularly derived that can initiate and perpetuate immune responses following trauma, ischemia other types of tissue damage in the absence pathogenic infection. High mobility group box 1 (HMGB1) is a prototypical DAMP associated with hallmarks cancer. Recently we found HMGB1 release after chemotherapy treatment critical regulator autophagy potential drug target for therapeutic interventions leukemia. Overexpression by gene...
Background Radiofrequency ablation (RFA) is one of the curative therapies for hepatocellular carcinoma (HCC), however, accelerated progression residual HCC after incomplete RFA has been reported more frequently. The underlying molecular mechanism this phenomenon remains to be elucidated. In study, we used an orthotopic nude mouse model study invasive and metastatic potential cancer as well correlated mechanism. Methods models were established using high cell line HCCLM3 low HepG2,...
Calpain small subunit 1 (Capn4) has been identified as a major gene that promotes metastasis of hepatocellular carcinoma (HCC). However, the mechanism by which Capn4 progression HCC is not understood. In this study, we found expression was increased in highly metastatic cell lines and tumour tissue from patients compared to healthy patient tissue. Over-expression cells enhanced growth vitro invasiveness, tumourigenicity lung vivo. Protein microarray analyses showed multiple proteins...
Monoacylglycerol lipase (MAGL), a critical lipolytic enzyme, has emerged as key regulator of tumor progression, yet its biological function and clinical significance in hepatocellular carcinoma (HCC) is still unknown. In this study, we used tissue microarray containing samples from 170 HCC patients to evaluate the expression MAGL correlation with other clinicopathologic characteristics. addition, investigated regulating effects on various lines. Finally, identified NF-κB signaling pathway...
Endometrial regenerative cells (ERCs), a novel type of mesenchymal-like stem cell derived from menstrual blood, have been recently evaluated as an attractive candidate source in ulcerative colitis (UC); however, the mechanism is not fully understood. The present study was designed to investigate effects ERCs, especially on B-cell responses UC. In this study, induced by administering 3% dextran sodium sulfate (DSS) via free drinking water for 7 days BALB/c mice. treated group, mice were...
Radiofrequency ablation (RFA) therapy has proven to be effective and feasible for early-stage hepatocellular carcinoma (HCC); however, rapid progression of residual tumor cells after RFA been confirmed, but the molecular mechanisms this phenomenon are poorly understood. This study evaluated effect lipid raft proteins known as flotillins on invasive metastatic potential HCC.The human HCC cell line HCCLM3 was used establish insufficient models in vivo vitro. Changes cellular morphology, soft...
Background: Hepatocellular carcinoma (HCC) is one of the most leading causes cancer-related mortality worldwide.Immune checkpoint inhibitors (ICIs) have been proved to be beneficial for advanced HCC.Tumor mutational burden (TMB) an important predictor efficacy ICIs.However, genetic landscape Chinese HCC patients and association between TMB frequently mutated genes remain unclear.Methods: Whole-exome sequencing data 369 liver tumors from Cancer Genome Altas (TCGA) next generation (NGS) 657...