This paper described the energy-transfer amplified singlet oxygen generation in semiconductor polymer dots (Pdots) for vitro and vivo photodynamic therapy. Hydrophobic photosensitizer tetraphenylporphyrin was facilely doped nanoparticles consisting of densely packed polymers. Optical characterizations indicated that fluorescence Pdots completely quenched by photosensitizer, yielding an energy transfer efficiency nearly 100% singlet-oxygen quantum yield ∼50%. We evaluated cellular uptake,...

The combination of immunotherapy with platinum-based chemotherapy has become the first-line treatment for patients advanced non-small cell lung cancer (NSCLC) negative driver gene mutations. However, finding an ideal chemotherapeutic regimen and exploring underlying mechanism have noticeably attracted clinicians' attention. In this study, we found that cisplatin induced ferroptosis tumor cells, followed by N1 neutrophil polarization in microenvironment, which turn remodeled "cold" to a "hot"...

A 61-year-old man was admitted to the gastroenterology department with a history of abdominal discomfort. He denied any past illness and family malignant tumors. Laboratory, electrocardiogram, physical examination showed no obvious abnormality. Later, patient underwent colonoscopy, 1.0*1.0 cm submucosal tumor (SMT) presented at appendiceal orifice. Endoscopic ultrasound that SMT well-distributed hyperechoic lesion. dissection (ESD) performed, resected in whole piece. Post-ESD...

Helicobacter pylori (H. pylori) has attracted much attention since its discovery. This bacterium had a substantial impact on society, the economy, and public health. In recent years, with continuous increase in drug resistance H. emergence of multidrug resistant strains, existing diagnostic treatment options are no longer able to meet clinical needs, so we need understand dynamically changing nature our region. study collected stool samples from community residents Lianyungang analyse local...

Methyltransferase like 3 (METTL3) has been identified to serve as a definitive inducer in cancer progression. This study sought analyze the regulatory mechanism of METTL3 epithelial-mesenchymal transition (EMT), invasion, and metastasis esophageal (ESCA). The expressions tissues cells were detected with extensive analysis its correlation clinical baseline data. transfected sh-RNA-METTL3 microRNA (miR)-20a-5p mimic, followed by evaluation migration, EMT. N6-methyladenosine (m6A) level...

Programmed cell death-1 (PD-1) -targeted immunotherapy has become a promising treatment paradigm for patients with advanced non-small lung cancer (NSCLC).Clinical responses to checkpoint inhibition therapy in NSCLC have been associated programmed ligand 1 (PD-L1) expression.However, the association between expression of PD-L1 and PD-L2 clinicopathological features patient outcomes remain unclear.We retrospectively analyzed 364 (158 squamous carcinoma 206 adenocarcinoma) who underwent...

Background: In recent years, great improvement has been made in immunotherapies for non-small cell lung cancer (NSCLC). Current data have suggested that Programmed death ligand 1 (PD-L1) expression might not be an ideal marker patient selection isolation. Evidence increasing alternative markers, such as neutrophil-to-lymphocyte ratio (NLR), a biomarker of systemic inflammation response (SIR) previously associated with outcomes variety cancers including NSCLC, predictor and the to therapy. No...

Abstract Background Previous studies have shown that lncRNA LINC00662 plays an important role in pathogenesis of malignancies. The purpose this study was to elucidate the regulatory mechanism esophageal squamous cell carcinoma (ESCC). Methods In study, investigated by RT‐qPCR. MTT, transwell and dual luciferase reporter assays. Results Upregulation found ESCC associated with worse clinical outcomes patients. More importantly, knockdown restrained proliferation, migration invasion ESCC....

Abstract Increased abnormal spindle‐like microcephaly (ASPM) expression has been linked to clinical stage and poor prognosis in cancers, but the molecular mechanisms by which ASPM promotes cell metastasis colorectal cancer (CRC) not identified. This study showed that abilities of migration, invasion, epithelial–mesenchymal transition (EMT) were attenuated ASPM‐deficient CRC lines. Furthermore, we reported attenuation inhibited vivo. Additionally, was positively correlated with β‐catenin...

We investigated the cellular uptake behavior and cell viability of semiconducting polymer dots (Pdots) on human gastric adenocarcinoma (SGC‐7901) cells mucosal (GES‐1) cells. MTT studies indicate Pdot treatment induces obvious proliferation in both types lines. performed further investigations such as reactive oxygen species (ROS) generation mitochondrial membrane potential (MMP) change, which that is good agreement with increase ROS MMP levels. Moreover, expression protein kinase B (Akt)...

BACKGROUND An extensive body of research reveals the clinical value serum tumor markers in lung cancer patients, including carcinoembryonic antigen (CEA), squamous cell carcinoma (SCCA), cytokeratin-19 fragments (Cyfra21-1), and neuron-specific enolase (NSE), but little is known about properties these anaplastic lymphoma kinase (ALK)-positive patients. MATERIAL AND METHODS We retrospectively analyzed 54 patients harboring ALK rearrangements 520 without rearrangements, all were treated...

Accumulating evidence indicates that miRNAs (miRs) play crucial roles in the modulation of tumors development. However, accurately mechanisms have not been entirely clarified. In this study, we aimed to explore role miR-200b development gastric cancer (GC).Western blot and RT-PCR were applied detect epithelial-mesenchymal transition (EMT) marker expression mRNA expression. Transwell assay was used for measuring metastasis invasiveness GC cells. TargetScan system, luciferase reporter assay,...

We aimed to explore the role of Solute Carrier Family 35 Member F2 (SLC35F2) in pancreatic cancer (PCa) and further study whether SLC35F2 regulates cisplatin resistance PCa cells through modulation RNA binding motif protein 14 (RBM14) expression. expression 60 pairs tissues adjacent ones was studied by RT-PCR analysis. Meanwhile, levels cell lines were also evaluated qPCR assay. In addition, knockdown models constructed cisplatin-resistant cells. Furthermore, we determined interaction...

In this work, the competitive adsorption behavior of H<sub>2</sub> and CO on strained Fe(110) are investigated by first-principles method based spin-polarized density functional theory to study hydrogen embrittlement steels. The results show that most stable site for is top site, orbital molecule hybridizing with Fe 3p 4s states illustrates a strong electronic interaction between them. energy values at four calculated sites more negative than those H<sub>2</sub>,...

Water soluble NaYF 4 nanocrystals codoped with 20 mol% Yb 3+ , 2 Er were prepared by a facile solvothermal approach using polyvinylpyrrolidone (PVP) as surfactant. As potential material for luminescent probes, in votroeffects of upconversion nanoparticles (UCNPs) on human aenocarcinoma (SGC-7901) cells different concentrations observed. These effects range from cell viability, mitochondrial membrane (MMP), reactive oxygen species (ROS) production, AnnexinV-FITC–propidiumiodide (PI) apoptosis...

For better understanding of radiotherapy resistance and its potential mechanism.We established radioresistance cell lines non-small lung cancer (NSCLC) followed by microarray analysis. 529 differentially expressed genes (DEGs) were then screened between radiation resistant compared with the sensitive lines. The biological functions enrichment pathways above DEGs identified using Kyoto Encyclopedia Genes Genomes (KEGG) gene ontology (GO) analyses. Gene Set Enrichment Analysis (GSEA) revealed...

Esophageal squamous cell carcinoma (ESCC) is characterized by a poor prognosis and has significant impact on patient survival quality of life. The role N6-methyladenosine (m6A) modification in the regulation long non-coding RNAs (lncRNAs) messenger (mRNAs) been reported various diseases, including cancer. Although clinical value lncRNA-FNDRR predicting ESCC well-established, its molecular mechanism remains incompletely understood. Therefore, this study, we aimed to investigate involvement...

The combination of immunotherapy with platinum-based chemotherapy has become the first-line treatment for patients advanced non-small-cell lung cancer (NSCLC) negative driver gene mutations. However, finding an ideal chemotherapeutic regimen and exploring underlying mechanism have noticeably attracted clinicians’ attention. In this study, we found that cisplatin induced ferroptosis tumors cells, followed by N1 neutrophil polarization in tumor microenvironment, which turn remodeled “cold” to...