A5100364528- MicroRNA in disease regulation
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Air Quality and Health Impacts
- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Climate Change and Health Impacts
- RNA modifications and cancer
- Heavy Metal Exposure and Toxicity
- Genetic factors in colorectal cancer
- Air Quality Monitoring and Forecasting
- Cancer Genomics and Diagnostics
- Cancer Risks and Factors
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Global Health Care Issues
- Liver Disease Diagnosis and Treatment
- Trace Elements in Health
- HIV, Drug Use, Sexual Risk
- Lung Cancer Treatments and Mutations
- Genetics and Neurodevelopmental Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Autophagy in Disease and Therapy
Jiangsu Province Hospital
2017-2025
Xinjiang Medical University
2023-2025
Nanjing Medical University
2008-2025
Affiliated Hospital of Jiangsu University
2025
VA Connecticut Healthcare System
2023-2025
Kunming Institute of Zoology
2017-2025
Chinese Academy of Sciences
2016-2025
Yale University
2023-2025
University of Occupational and Environmental Health Japan
2025
Zhejiang Chinese Medical University
2022-2025
Cisplatin (CDDP) treatment is one of the most predominant chemotherapeutic strategies for patients with gastric cancer (GC). A better understanding mechanisms CDDP resistance can greatly improve therapeutic efficacy in GC. Circular RNAs (circRNAs) are a class noncoding whose functions related to pathogenesis cancer, but, GC remains unknown. circAKT3 (hsa_circ_0000199, circRNA originating from exons 8, 9, 10, and 11 AKT3 gene) was identified by RNA sequencing verified quantitative reverse...
Abstract Problematic alcohol use (PAU), a trait that combines disorder and alcohol-related problems assessed with questionnaire, is leading cause of death morbidity worldwide. Here we conducted large cross-ancestry meta-analysis PAU in 1,079,947 individuals (European, N = 903,147; African, 122,571; Latin American, 38,962; East Asian, 13,551; South 1,716 ancestries). We observed high degree cross-ancestral similarity the genetic architecture identified 110 independent risk variants within-...
Cisplatin (CDDP) resistance is a major clinical problem associated with poor prognosis in gastric cancer (GC) patients. In this study, we performed integrated analysis of TCGA data from microRNAs (miRNAs) expression matrix GC patients who received CDDP-based chemotherapy GEO dataset which contains differential miRNAs profiles CDDP-resistant and -sensitive cell lines. We identified miR-148a-3p downregulation as key step involved CDDP resistance. Using cohort consisting 105 therapy, found that...
Background Although the entire duration of fetal development is generally considered a highly susceptible period, it public health interest to determine narrower window heightened vulnerability polycyclic aromatic hydrocarbons (PAHs) in humans. We posited that exposure PAHs during first trimester impairs growth more severely than similar level subsequent trimesters. Methods In group healthy, non-smoking pregnant women with no known risks adverse birth outcomes, personal eight airborne was...
Phthalates and bisphenol A (BPA) are ubiquitous environmental toxicants, present in high concentrations numerous consumer products. We hypothesized that maternal exposure to phthalates BPA pregnancy is associated with shortened gestation.Urinary phthalate metabolites from 72 pregnant women were measured at the last obstetric clinic visit prior delivery. Using linear regression models, we estimated change gestational age each interquartile range (IQR) increase metabolite concentration.IQR...
Fine particulate matter (PM) air pollution is associated with numerous adverse health effects, including increased blood pressure (BP) and vascular dysfunction. Coarse PM substantially contributes to global pollution, yet differs in characteristics from fine particles currently not regulated. However, the cardiovascular (CV) impacts of coarse exposure remain largely unknown.Our goal was elucidate whether PM, like itself capable eliciting CV responses.We performed a randomized double-blind...
MicroRNAs are endogenously expressed, small non-coding RNAs that modulate gene expression by targeting specific mRNAs, resulting in translational repression or mRNA degradation. Although miR-584-5p has been reported to play a vital role various malignancies, its and the molecular mechanisms underlying effects of gastric cancer (GC) remain be clarified. In this study, we investigated GC. The target were determined human GC specimens cell lines microRNA real-time polymerase chain reaction...
Background: Health literacy is an increasingly important public health concern. However, little known about the of general in China. The aim this study was to evaluate prevalence low and demographic associations Shanghai, Methods: This a community-based cross-sectional survey utilizing multi-stage random sampling design. sample consisted 1360 individuals aged 15–69 years with total community-dwelling Chinese as frame. measured by questionnaire developed on basis national manual released...
Immune dysregulation associated with mercury has been suggested, although data in the general population are lacking. Chronic exposure to low levels of methylmercury (organic) and inorganic is common, such as through fish consumption dental amalgams.We examined associations between biomarkers antinuclear antibody (ANA) positivity titer strength.Among females 16-49 years age (n = 1,352) from National Health Nutrition Examination Survey (NHANES) 1999-2004, we cross-sectional ANAs (indirect...
Abstract Increasing evidence indicates that dysregulation of microRNAs (miRNAs) plays a crucial role in human malignancies. Here, we showed microRNA-422a (miR-422a) expression was dramatically downregulated gastric cancer (GC) samples and cell lines compared with normal controls, its level inversely related to tumor size depth infiltration. Functional studies revealed the overexpression miR-422a GC cells suppressed proliferation migration, drove metabolic shift from aerobic glycolysis...
Increasing evidence indicates that microRNAs (miRNAs) play an important role in various tumors by regulating downstream target genes and diverse signaling pathways. Herein, we confirmed miR-1265 expression gastric cancer (GC) using the Cancer Genome Atlas (TCGA) database assessed level of clinical specimens cell lines. We found was negatively correlated with tumor size. Further functional analysis revealed suppresses cellular proliferation autophagy while inducing apoptosis GC cells. A...
Abstract Background Recent studies have investigated the role of circular RNAs (circRNAs) as significant regulatory factors in multiple cancer progression. Nevertheless, biological functions circRNAs and underlying mechanisms by which they regulate colorectal (CRC) progression remain unclear. Methods A novel circRNA (circ-GALNT16) was identified microarray qRT-PCR. series vitro vivo phenotype experiments were performed to investigate circ-GALNT16 CRC. The FISH, RNA pulldown assay, RIP...
Abstract Background We aimed to determine whether and how the combination of acetazolamide remote ischemic preconditioning (RIPC) reduced incidence severity acute mountain sickness (AMS). Methods This is a prospective, randomized, open-label, blinded endpoint (PROBE) study involving 250 healthy volunteers. Participants were randomized (1:1:1:1:1) following five groups: Ripc (RIPC twice daily, 6 days), Rapid-Ripc four times 3 Acetazolamide (twice 2 Combined (Acetazolamide plus Rapid-Ripc),...
Background: Age is the most important risk factor for cancer, but aging rates are heterogeneous across individuals. We explored a new measure of aging-Phenotypic (PhenoAge)-in prediction site-specific and overall cancer. Methods: Using Cox regression models, we examined association Phenotypic Acceleration (PhenoAgeAccel) with cancer incidence by genetic group among 374,463 participants from UK Biobank. generated PhenoAge using chronological age nine biomarkers, PhenoAgeAccel after...