A5043796579- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Multiple Myeloma Research and Treatments
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Protein Degradation and Inhibitors
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Phagocytosis and Immune Regulation
- Circular RNAs in diseases
- Algal biology and biofuel production
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Genetic Associations and Epidemiology
- Immune cells in cancer
- Cancer Research and Treatments
- Diabetes Treatment and Management
- Cancer Treatment and Pharmacology
- Liver Disease Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Medical Research and Treatments
- Genetic factors in colorectal cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Hypoxia, and Metabolism
- Electrolyte and hormonal disorders
Xinjiang Medical University
2025
Shandong First Medical University
2023-2025
Jiangsu Province Hospital
2022-2025
Chongqing Medical University
2023-2025
Huazhong Agricultural University
2025
Heze Municipal Hospital
2025
Nanjing Medical University
2022-2025
Hubei Provincial Hospital of Traditional Chinese Medicine
2025
BGI Genomics
2023-2024
Fuzhou Second Hospital
2023-2024
Lung cancer is the leading cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) have emerged as key regulators development and progression, promising biomarkers for diagnosis prognosis cancer. In this study, we identified a new lncRNA (LINC02159) that was upregulated in tumor tissues serum non-small cell lung (NSCLC) patients. We demonstrated knockdown LINC02159 inhibited NSCLC proliferation, migration, invasion, but induced apoptosis cycle arrest vitro retarded growth...
Abstract Context Inhibition of the neonatal fragment crystallizable receptor (FcRn) reduces pathogenic thyrotropin antibodies (TSH-R-Ab) that drive pathology in thyroid eye disease (TED). Objective We report first clinical studies an FcRn inhibitor, batoclimab, TED. Design Proof-of-concept (POC) and randomized, double-blind placebo-controlled trials. Setting Multicenter. Participants Patients with moderate-to-severe, active Intervention In POC trial, patients received weekly subcutaneous...
Multiple myeloma (MM) is a plasma cell malignancy that still considered to be incurable in most cases. A dominant mutation cluster has been identified RAS/RAF genes, emphasizing the potential significance of RAS/RAF/MEK/ERK signaling as therapeutic target. As yet, however, clinical relevance this finding unclear responses MEK inhibition RAS-mutant MM have mixed. We therefore assessed status and MEK/ERK pathway activation by both targeted sequencing phospho-ERK immunohistochemistry 180 tissue...
There is a need to explore combination therapy improve the efficacy of immunotherapy for colorectal cancer through food probiotics. In this study, extracellular vesicles (EV) derived from Lactobacillus rhamnosus GG (LGG-EV) were successfully isolated. Adjusting culture temperature 30 °C led an elevated LGG-EV yield, and addition penicillin resulted in decrease particle size. addition, have better gastrointestinal tract stability Ca2+ environment vivo vitro. Oral administration...
Toxic epidermal necrolysis (TEN) is a rare severe cutaneous adverse reaction that involves more than 30% of the body surface area. TEN can be accompanied by series systemic symptoms and has high risk death. Tumor necrosis factor (TNF)-α inhibitors such as adalimumab etanercept have been shown to safe effective for treatment in some cases. However, clinical data on use TNF-α treat with infection are scarce. In present study, three adult patients who developed serious active were successfully...
Background: Approximately 60% of patients with CRLM experience relapse within 2 years after radical resection, previous studies have proven that repeat local treatment (LT) could prolong survival, however, it is difficult to seize the window for LT due lack a high-sensitive surveillance method. In this study, we aim examine value longitudinal circulating tumor DNA (ctDNA) in guiding adjuvant chemotherapy (ACT), optimizing clinical strategy, and thereby improving outcomes. Materials Methods:...
The outcomes of patients with multiple myeloma (MM) refractory to immunomodulatory agents (IMiDs) and proteasome inhibitors (PIs) remain poor. In this study, we performed whole genome transcriptome sequencing 39 heavily pretreated relapsed/refractory MM (RRMM) identify mechanisms resistance potential therapeutic targets. We observed a high mutational load indications increased genomic instability. Recurrently mutated genes in RRMM, which had not been previously reported or only at lower...
Feed efficiency (FE) is a crucial trait in pig production that influences both economic viability and environmental sustainability. The jejunum, an essential organ for nutrient absorption, plays significant role determining FE by affecting how pigs process utilize feed. To explore the genetic regulatory mechanisms behind FE, we conducted integrative multi-omics study using RNA sequencing (RNA-seq) ATAC (ATAC-seq) on with high low FE. By comparing gene expression chromatin accessibility...
Abstract This observational investigation aimed to explore potential risk factors for anemia in pregnancy. Firstly, a cross-sectional study was conducted, encompassing review of clinical data 43,201 pregnant women admitted the Hainan Women and Children’s Medical Center between January 2017 December 2020. Comparison with without pregnancy revealed significant differences two groups concerning age, gestational diabetes, hypothyroidism, hyperthyroidism, chronic hepatitis B virus infection,...
Genome-wide association studies have identified thousands of genetic variants associated with non-small cell lung cancer (NSCLC), however, it is still challenging to determine the causal and improve disease risk prediction. Here, we applied massively parallel reporter assays perform NSCLC variant-to-function mapping at scale. A total 1249 candidate were evaluated, 30 potential within 12 loci identified. Accordingly, proposed three architectures underlying susceptibility: multiple in a single...
Multiple myeloma (MM) remains an incurable hematologic malignancy due to the inevitable development of drug resistance, particularly in relapsed or refractory cases. Post-translational modifications (PTMs), including phosphorylation, ubiquitination, acetylation, and glycosylation, play pivotal roles regulating protein function, stability, interactions, thereby influencing MM pathogenesis therapeutic resistance. This review comprehensively explores mechanisms by which dysregulated PTMs...
Recent research unveiled that LINC00857 plays a regulatory role in multiple human cancers, such as lung adenocarcinoma and gastric cancer. Nevertheless, the function of pancreatic (PAAD) remains unclear. This study concentrates on to discuss relevant molecular mechanism this gene PAAD. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) western blot were implemented for measuring expressions RNAs proteins. Wound healing Transwell assays used assess cell migration invasion,...
Hypoxia is identified as one of the microenvironmental features most solid tumors and involved in tumor progression. In present research, we demonstrate that lncRNA extracellular leucine rich repeat fibronectin type III domain-containing 1-antisense RNA 1 (ELFN1-AS1) upregulated by hypoxia colon cancer cells. Knockdown ELFN1-AS1 hypoxic cells can reduce cell proliferation restore invasion to non-hypoxic levels. Fluorescence situ hybridization results show distributed cytoplasm cells, so...
Abstract Objectives To assess the safety, tolerability, and key pharmacodynamic effects of subcutaneous batoclimab, a fully human anti‐neonatal Fc receptor monoclonal antibody, in patients with generalized myasthenia gravis anti‐acetylcholine antibodies. Methods A Phase 2a, proof‐of‐concept, randomized, double‐blind, placebo‐controlled trial is described. Eligible were randomized (1:1:1) to receive once‐weekly injections batoclimab 340 mg, 680 or matching placebo for 6 weeks. Subsequently,...