A5081351303- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Immune cells in cancer
- Cancer Cells and Metastasis
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Renal and related cancers
- Cell Adhesion Molecules Research
- Virus-based gene therapy research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Liver Disease Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Tissue Engineering and Regenerative Medicine
- Wnt/β-catenin signaling in development and cancer
- NF-κB Signaling Pathways
Jiangsu University
2016-2025
First Affiliated Hospital of Xi'an Jiaotong University
2023-2025
Chinese PLA General Hospital
2015-2025
Sun Yat-sen University
2020-2025
Sun Yat-sen University Cancer Center
2021-2025
China Medical University
2023-2025
First People's Hospital of Kunshan
2025
Shandong University
2025
The Military General Hospital of Beijing PLA
2025
PLA Academy of Military Science
2024
Mesenchymal stem cells (MSCs) have been considered as an attractive tool for the therapy of diseases. Exosomes excreted from MSCs can reduce myocardial ischemia/reperfusion damage and protect against acute tubular injury. However, whether MSC-derived exosomes relieve liver fibrosis its mechanism remain unknown. Previous work showed that human umbilical cord-MSCs (hucMSCs) transplanted into acutely injured fibrotic livers could restore function improve fibrosis. In this study, it was found...
Abstract Mesenchymal stem cell-derived exosomes (MSC-Ex) play important roles in tissue injury repair, however, the of MSC-Ex skin damage repair and its mechanisms are largely unknown. Herein, we examined benefit human umbilical cord MSC-derived exosome (hucMSC-Ex) cutaneous wound healing using a rat burn model. We found that hucMSC-Ex-treated wounds exhibited significantly accelerated re-epithelialization, with increased expression CK19, PCNA, collagen I (compared to III) vivo. HucMSC-Ex...
Abstract Human umbilical cord mesenchymal stem cells (hucMSCs) and their exosomes have been considered as potential therapeutic tools for tissue regeneration; however, the underlying mechanisms are still not well understood. In this study, we isolated characterized from hucMSCs (hucMSC-Ex) demonstrated that hucMSC-Ex promoted proliferation, migration, tube formation of endothelial in a dose-dependent manner. Furthermore, wound healing angiogenesis vivo by using rat skin burn model. We...
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic and claimed over million lives worldwide. Although the genetic sequences of SARS-CoV SARS-CoV-2 have high homology, clinical pathological characteristics COVID-19 differ significantly from those SARS. How whether evades (cellular) immune surveillance requires further elucidation. In this study, we show that infection leads to major histocompability complex class Ι (MHC-Ι)...
Exosomes are nanosized extracellular vesicles (EVs) that show great promise in tissue regeneration and injury repair as mesenchymal stem cell (MSC). MSC has been shown to alleviate diabetes mellitus (DM) both animal models clinical trials. In this study, we aimed investigate whether exosomes from human umbilical cord (hucMSC-ex) have a therapeutic effect on type 2 DM (T2DM). We established rat model of T2DM using high-fat diet streptozotocin (STZ). found the intravenous injection hucMSC-ex...
Abstract Resident macrophages in the tumor microenvironment exert a dual role progression. So far, mechanism of intratumoral macrophage generation is still largely unknown. In present study, importance pro-tumor gastric cancer-derived mesenchymal stromal cells (GC-MSCs) was observed mouse xenograft model with depletion. cancer tissues, high expression levels Ym-1, Fizz-1, arginase-1, and CCR-2, as well low level iNOS, were verified, co-localization GC-MSCs tumor-associated (TAMs) by...
Exosomes are extracellular vesicles that mediate cellular communication in health and diseases. Neutrophils could be polarized to a pro-tumor phenotype by tumor. The function of tumor-derived exosomes neutrophil regulation remains unclear. We investigated the effects gastric cancer cell-derived (GC-Ex) on activation neutrophils elucidated underlying mechanisms. GC-Ex prolonged survival induced expression inflammatory factors neutrophils. GC-Ex-activated neutrophils, turn, promoted cell...
Mesenchymal stem cells (MSCs) play an important role in chemoresistance. Exosomes have been reported to modify cellular phenotype and function by mediating cell-cell communication. In this study, we aimed investigate whether exosomes derived from MSCs (MSC-exosomes) are involved the resistance chemotherapy gastric cancer explore underlying molecular mechanism. We found that MSC-exosomes significantly induced of 5-fluorouracil both vivo ex vivo. antagonized 5-fluorouracil-induced apoptosis...
Exosomes secreted by mesenchymal stem cells (MSCs) have shown repairing effects on several tissue injury diseases. In this study, we aimed to investigate the of exosomes released from human umbilical cord (hucMSCs) treatment dextran sulfate sodium- (DSS-) induced inflammatory bowel disease (IBD) and explore underlying mechanism. We found that indocyanine green (ICG) labeled homed colon tissues IBD mice at 12 hours after injection. significantly relieved severity in as hucMSCs. The expression...
Summary SARS-CoV-2 infection have caused global pandemic and claimed over 5,000,000 tolls 1–4 . Although the genetic sequences of their etiologic viruses are high homology, clinical pathological characteristics COVID-19 significantly differ from SARS 5,6 Especially, it seems that undergoes vast replication in vivo without being effectively monitored by anti-viral immunity 7 Here, we show viral protein encoded open reading frame 8 (ORF8) SARS-CoV-2, which shares least homology with SARS-CoV...
Neutrophil-derived exosomes induce tumor cell apoptosis by delivering cytotoxic proteins and activating caspase signaling pathway.
Abstract Long non-coding RNAs (LncRNAs) have been suggested as important regulators of cancer development and progression in non-small cell lung (NSCLC). Nevertheless, the biological roles clinical significance lncRNA UFC1 NSCLC remain unclear. We detected expression tumor tissues, serum, serum exosomes patients by qRT-PCR. Gene overexpression or silencing were used to examine NSCLC. RNA immunoprecipitation ChIP assays performed evaluate interaction between enhancer zeste homolog 2 (EZH2)...
Abstract Background Circular RNAs (circRNAs) play important roles in cancer development and progression. The purpose of this study is to identify aberrantly expressed circRNAs gastric (GC), unravel their GC progression, provide new targets for diagnosis therapy. Methods Bioinformatic analyses were performed the expression hsa_circ_0061137 (termed as circDIDO1) GC. Gain- loss-of-function studies examine biological circDIDO1 Tagged RNA affinity purification, mass spectrometry,...
Abstract Background Human umbilical cord mesenchymal stem cell (hucMSC)-derived exosomes are recognized as novel cell-free therapeutic agents for inflammatory bowel disease (IBD), a condition caused by dysregulated intestinal mucosal immunity. In this event, macrophage pyroptosis, process of death following the activation NLRP3 (NOD-like receptor family, pyrin domain-containing 3) inflammasomes, is believed to partially account reactions. However, role pyroptosis in hucMSC-derived...
Traditional drug-based treatments for inflammatory bowel disease (IBD) have significant limitations due to their potential off-target systemic side-effects. Currently, there is a lack of understanding on how effectively address excessive oxidative stress, dysregulated immune homeostasis, and microbiota dysbiosis within the IBD microenvironment. Herein, we introduce nanotherapeutic approach, named LBL-CO@MPDA, treatment. LBL-CO@MPDA an orally administered formulation that supplies carbon...