A5036822385- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- Pancreatic function and diabetes
- Pluripotent Stem Cells Research
- RNA Interference and Gene Delivery
- HIV Research and Treatment
- Circular RNAs in diseases
- interferon and immune responses
- Sperm and Testicular Function
- Microtubule and mitosis dynamics
- Neuroendocrine Tumor Research Advances
- HIV/AIDS drug development and treatment
Sun Yat-sen University
2016-2025
Harbin Medical University
2024-2025
Second Affiliated Hospital of Harbin Medical University
2025
First Affiliated Hospital of Jinan University
2025
Qinghai University
2024
UPMC Hillman Cancer Center
2017-2024
Cancer Research Institute
2017-2024
University of Pennsylvania
2015-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2016-2024
City Of Hope National Medical Center
2021-2024
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic and claimed over million lives worldwide. Although the genetic sequences of SARS-CoV SARS-CoV-2 have high homology, clinical pathological characteristics COVID-19 differ significantly from those SARS. How whether evades (cellular) immune surveillance requires further elucidation. In this study, we show that infection leads to major histocompability complex class Ι (MHC-Ι)...
Objective We aimed to elucidate the mutual regulation mechanism of ubiquitin-specific protease 22 (USP22) and hypoxia inducible factor-1α (HIF1α), they promote stemness hepatocellular carcinoma (HCC) cells under hypoxic conditions. Design Cell counting, migration, self-renewal ability, chemoresistance expression genes were established detect HCC cells. Immunoprecipitation, ubiquitination assay chromatin immunoprecipitation used USP22 HIF1α. patient samples The Cancer Genome Atlas data...
Alterations in fibroblast growth factor receptor (FGFR) genes have been identified as potential driver oncogenes. Pharmacological targeting of FGFRs may therefore provide therapeutic benefit to selected cancer patients, and proof-of-concept has established early clinical trials FGFR inhibitors. Here, we present the molecular structure preclinical characterization INCB054828 (pemigatinib), a novel, selective inhibitor 1, 2, 3, currently phase 2 trials. pharmacokinetics pharmacodynamics were...
Abstract Viruses, as opportunistic intracellular parasites, hijack the cellular machinery of host cells to support their survival and propagation. Numerous viral proteins are subjected host-mediated post-translational modifications. Here, we demonstrate that SARS-CoV-2 nucleocapsid protein (SARS2-NP) is SUMOylated on lysine 65 residue, which efficiently mediates SARS2-NP’s ability in homo-oligomerization, RNA association, liquid-liquid phase separation (LLPS). Thereby innate antiviral immune...
Abstract Since the outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2), public health worldwide has been greatly threatened. The development an effective treatment for this infection is crucial and urgent but hampered incomplete understanding viral mechanism lack specific antiviral agents. We previously reported that teicoplanin, a glycopeptide antibiotic commonly used in clinic to treat bacterial infection, significantly restrained cell...
PIWI-interacting RNA (piRNA) silences the transposons in germlines or induces epigenetic modifications invertebrates. However, its function mammalian somatic cells remains unknown. Here we demonstrate that a piRNA derived from Growth Arrest Specific 5, tumor-suppressive long non-coding RNA, potently upregulates transcription of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), proapoptotic protein, by inducing H3K4 methylation/H3K27 demethylation. Interestingly, PIWIL1/4...
Abstract The discovery of PIWI-interacting RNAs (piRNAs) revealed the complexity RNA world. Although piRNAs were first deemed to be germline specific, substantial evidence shows their various roles in somatic cells; however, function highly differentiated immune cells remains elusive. In this study, by initially screening with a small deep-sequencing analysis, we found that piRNA, tRNA-Glu–derived piRNA [td-piR(Glu)], was expressed much more abundantly human monocytes than dendritic cells....
Abstract COVID-19 is identified as a zoonotic disease caused by SARS-CoV-2, which also can cross-transmit to many animals but not mice. Genetic modifications of SARS-CoV-2 or mice enable the susceptible viral infection. Although neither natural situation, they are currently utilized establish mouse infection models. Here we report direct contact transmission variant B.1.351 in wild-type The (B.1.351) replicated efficiently and induced significant pathological changes lungs tracheas,...
Abstract Widespread drug resistance has become the key issue in global healthcare. Extensive efforts have been made to reveal not only diverse diseases experiencing resistance, but also six distinct types of molecular mechanisms underlying this resistance. A database that describes a comprehensive list with (not just cancers/infections) and all is now urgently needed. However, no such available date. In study, describing information named ‘DRESIS’ was therefore developed. It introduced (i)...
Abstract Background Mesenchymal stem cells (MSCs) are promising candidates for tissue regeneration and disease treatment. However, long-term in vitro passaging leads to stemness loss of MSCs, resulting failure MSC therapy. This study investigated whether the combination melatonin human umbilical cord mesenchymal (hUC-MSCs) was superior hUC-MSCs alone ameliorating high-fat diet streptozocin (STZ)-induced type II diabetes mellitus (T2DM) a mouse model. Methods Mice were divided into four...
Abstract Background Existing treatments for cholangiocarcinoma have poor efficacy. However, chimeric antigen receptor‐T (CAR‐T) cells are emerging as a potential therapeutic strategy. Solid tumors possess multiple adverse factors in an immunosuppressive microenvironment that impair CAR‐T cell infiltration and function. This study aimed to improve the function of through knock down immune checkpoints molecular receptors. Methods We evaluated expression epidermal growth factor receptor (EGFR)...
Abstract Because of the rapid mutation and high airborne transmission SARS‐CoV‐2, a universal vaccine preventing infection in upper respiratory tract is particularly urgent. Here, mosaic receptor‐binding domain (RBD) nanoparticle (NP) developed, which induces more RBD‐targeted type IV neutralizing antibodies (NAbs) exhibits broad cross‐protective activity against multiple SARS‐CoV‐2 sublineages including newly‐emerged BF.7, BQ.1, XBB. As several T‐cell‐reactive epitopes, are highly conserved...
Abstract Current anticancer therapies cannot eliminate all cancer cells, which hijack normal arginine methylation as a means to promote their maintenance via unknown mechanisms. Here we show that targeting protein N -methyltransferase 9 (PRMT9), whose activities are elevated in blasts and leukemia stem cells (LSCs) from patients with acute myeloid (AML), eliminates disease cancer-intrinsic mechanisms cancer-extrinsic type I interferon (IFN)-associated immunity. PRMT9 ablation AML decreased...
Human immunodeficiency virus type 1 (HIV-1) infection is characterized by progressive depletion of CD4+ T lymphocytes and dysfunction the immune system. The numbers in human body are maintained constantly homeostatic mechanisms that failed during HIV-1 infection, resulting loss cells mainly via apoptosis. Recently, a non-apoptotic form necrotic programmed cell death, named necroptosis, has been investigated many biological pathological processes. We then determine whether HIV-1-infected also...