A5100333687- Per- and polyfluoroalkyl substances research
- Berberine and alkaloids research
- Fibroblast Growth Factor Research
- Treatment of Major Depression
- Methane Hydrates and Related Phenomena
- Carbon Dioxide Capture Technologies
- Medicinal plant effects and applications
- Inflammatory mediators and NSAID effects
- Anesthesia and Neurotoxicity Research
- Birth, Development, and Health
- Neurotransmitter Receptor Influence on Behavior
- Fungal Biology and Applications
- Synthesis of Indole Derivatives
- Kruppel-like factors research
- Cardiac, Anesthesia and Surgical Outcomes
- Epigenetics and DNA Methylation
- Cannabis and Cannabinoid Research
- Muscle Physiology and Disorders
- Eicosanoids and Hypertension Pharmacology
- Drug Transport and Resistance Mechanisms
- Cancer-related molecular mechanisms research
- Axial and Atropisomeric Chirality Synthesis
- Bioactive Natural Diterpenoids Research
- 14-3-3 protein interactions
- Neuroendocrine Tumor Research Advances
Binzhou Medical University
2023-2024
Hainan General Hospital
2024
Hainan Medical University
2024
Guiyang Medical University
2024
Shanxi Medical University
2024
Hong Kong Baptist University
2024
Affiliated Hospital of Guizhou Medical University
2024
Yangzhou University
2024
Beijing University of Chinese Medicine
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2023
Alterations in fibroblast growth factor receptor (FGFR) genes have been identified as potential driver oncogenes. Pharmacological targeting of FGFRs may therefore provide therapeutic benefit to selected cancer patients, and proof-of-concept has established early clinical trials FGFR inhibitors. Here, we present the molecular structure preclinical characterization INCB054828 (pemigatinib), a novel, selective inhibitor 1, 2, 3, currently phase 2 trials. pharmacokinetics pharmacodynamics were...
Abstract Trimethylamine- N -oxide (TMAO), a derivative from the gut microbiota metabolite trimethylamine (TMA), has been identified to be an independent risk factor for promoting atherosclerosis. Evidences suggest that berberine (BBR) could used treat obesity, diabetes and atherosclerosis, however, its mechanism is not clear mainly because of poor oral bioavailability. Here, we show BBR attenuated TMA/TMAO production in C57BL/6J ApoE KO mice fed with choline-supplemented chow diet, mitigated...
Aberrant activation of FGFR has been linked to the pathogenesis many tumor types. Selective inhibition emerged as a promising approach for cancer treatment. Herein, we describe discovery compound 38 (INCB054828, pemigatinib), highly potent and selective inhibitor FGFR1, FGFR2, FGFR3 with excellent physiochemical properties pharmacokinetic profiles. Pemigatinib received accelerated approval from U.S. Food Drug Administration treatment adults previously treated, unresectable locally advanced...
Multidrug-resistance (MDR) Pseudomonas aeruginosa (P. aeruginosa) is a lethal gram-negative pathogen causing hospital-acquired and ventilator-associated pneumonia, which difficult to treat. Our previous studies confirmed that baicalin, an essential bioactive component in Scutellaria baicalensis Georgi, exhibited anti-inflammatory effects acute pneumonia rat model induced by MDR P. aeruginosa. However, this effect of baicalin constrast its low bioavailability, mechanism action still unknown....
It has been demonstrated that berberine (BBR), a kind of alkaloid derived from Chinese herbal medicine, multiple pharmacological effects on human's diseases including anti-atherosclerosis action. However, although the previous studies showed beneficial impact BBR atherosclerosis might be associated with proprotein convertase subtilisin/kexin type 9 (PCSK9), exact underlying mechanism are not fully determined. The present study aimed to investigate potential mechanisms by using ApoE-/-...
Abstract Perfluorochemicals produce hepatotoxic effects via activation of peroxisome proliferator-activated receptor alpha (PPARα) and constitutive androstane (CAR) nuclear receptors in animals. Bile formation is one major liver function. But it remains unknown whether perfluorochemicals alter metabolism bile acids (BAs) liver. The present study was designed to determine the impact perfluorononanoic acid (PFNA) on BA cholesterol homeostasis mice. A single dose PFNA (0.1 mmol/kg)...
The activation of NOD-like receptor family, pyrin domain containing3 (NLRP3) inflammasome has been shown to be positively correlated with the severity proteinuria in chronic kidney disease (CKD) patients. Prostaglandin E2 (PGE2), an important inflammatory mediator, is also involved various injuries. aim present study was investigate involvement NLRP3 and PGE2 synthetic pathway albumin-induced renal tubular injury.Murine proximal cells (mPTCs) were treated albumin induce cell injury. siRNA...
Lesion mimic mutants are excellent models for research on molecular mechanisms of cell death and defense responses in rice. We identified a new rice lesion mutant lmm24 from pool indica cultivar “ZhongHui8015”. The LMM24 gene was by MutMap, confirmed as receptor-like cytoplasmic kinase 109 amino acid sequence analysis. displayed dark brown lesions leaves growth retardation that were not observed wild-type ZH8015. results histochemical staining TUNEL assays showed enhanced ROS accumulation...
Objective To investigate the relationships between perfluoroalkyl and polyfluoroalkyl substances (PFASs) exposure glucose metabolism indices. Methods Data from National Health Nutrition Examination Survey (NHANES) 2017–2018 waves were used. A total of 611 participants with information on serum PFASs (perfluorononanoic acid (PFNA); perfluorooctanoic (PFOA); perfluoroundecanoic (PFUA); perfluorohexane sulfonic (PFHxS); perfluorooctane sulfonates (PFOS); perfluorodecanoic (PFDeA)), indices...
Abstract Achieving high spatial resolution in matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is crucial for detailed molecular mapping biological tissues and cells. However, conventional MALDI-MSI platforms are typically limited to resolutions of 5-20 μm, restricting their ability visualize fine subcellular structures. Here, we present a novel ten-fold expansion (10X ExMSI) method that attains 500 nm without the need specialized optics or customized...
Phellinus igniarius has antibacterial, antiviral, antioxidative, antitumor, and antimutagenic effects. In this study, an integrative pattern recognition approach using principal component analysis orthogonal partial least squares discriminant was successfully applied for the rapid of natural compounds in traditional Chinese medicine. An ultra high performance liquid chromatography with synapt high‐definition mass spectrometry method MassLynx software used. This employed gradient elution to...
Abstract Aberrant signaling through Fibroblast Growth Factor Receptors (FGFR) has been reported in multiple types of human cancers. Genomic analyses squamous cell lung, gastric and urothelial tumors have revealed recurrent genetic alterations FGFR1, FGFR2 FGFR3 genes, respectively. FGFR proteins contribute to the development malignancies by promoting tumor proliferation, survival, migration supporting angiogenesis. Therefore targeting kinases may provide therapeutic benefit patients with...
Glucose transporter (Glut) 9 plays an important role in maintaining the homeostasis of uric acid body. Although physiologic functions Glut9 have been well established, regulation expression is less understood. In this study, we showed that mRNA and protein mouse liver kidney are female predominant. Ontogeny studies further revealed female-predominant only occurs adult mice, which primarily attributable to fact sustains females but gradually decreases males after it reaches peak level at day...
Abstract Epalrestat (EPS), an aldose reductase inhibitor, is widely prescribed to manage diabetic neuropathy. It generally believed that EPS beneficial patients because it can protect endothelial cells, Schwann or other neural cells from oxidative stress. However, several clinical studies revealed therapy led liver dysfunction, which limited its applications. Currently, the underlying mechanism by causes dysfunction unknown. This study aimed investigate responsible for EPS-induced injury. In...