A5058716920- Catalytic C–H Functionalization Methods
- Cyclopropane Reaction Mechanisms
- Superconducting Materials and Applications
- Catalytic Alkyne Reactions
- Magnetic confinement fusion research
- Particle accelerators and beam dynamics
- Traditional and Medicinal Uses of Annonaceae
- Oxidative Organic Chemistry Reactions
- Frequency Control in Power Systems
- Bioactive Compounds and Antitumor Agents
- Traditional Chinese Medicine Analysis
- Synthesis and Biological Evaluation
- Natural product bioactivities and synthesis
- Cholinesterase and Neurodegenerative Diseases
- Ubiquitin and proteasome pathways
- Physics of Superconductivity and Magnetism
- Plant Toxicity and Pharmacological Properties
- Herpesvirus Infections and Treatments
- Eicosanoids and Hypertension Pharmacology
- Botanical Research and Chemistry
- Immunotherapy and Immune Responses
- Chemical Synthesis and Analysis
- Virus-based gene therapy research
- Chemical synthesis and alkaloids
- Synthetic Organic Chemistry Methods
Central South University
2014-2025
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2024
Huazhong University of Science and Technology
2013-2024
Shanghai Shipbuilding Technology Research Institute
2024
Chinese Academy of Sciences
2012-2022
Kunming Institute of Botany
2011-2022
Wuhan Institute of Virology
2015-2022
Queen's University
2021
Shaanxi University of Chinese Medicine
2020
Southern University of Science and Technology
2019
A facile and straightforward method was developed to construct the fused tetracyclic 3-spirooxindole skeleton, which exists widely in natural products. The formation of structure achieved through a transition-metal-free intramolecular cross-dehydrogenative coupling pyridinium, were formed situ by condensation 3-(2-bromoethyl)indolin-2-one derivatives with 3-substituted pyridines. As examples application this new methodology, two potentially medicinal products, (±)-corynoxine B, efficiently...
The pollen of T. angustifolia, also known as Pu huang in Chinese, has been used for treatment stranguria, hematuria, dysmenorrhea, metrorrhagia and injuries China a long time. Extensive efforts have directed toward its phytochemical biological aspects. However, little is about anti-nociceptive implication material basis. This work presented the investigation effect Typhae Pollen using an effect-directed fractionation strategy, thereby leading to identification isorhamnetin-3-O-neohesperidin...
New synthetic procedures for the pyrrolo[2,3-b]indole skeleton have been developed via intramolecular annulation of indole derivatives under iodine(III). A series with different protecting groups or substitutions were explored to facilitate corresponding compounds in excellent yields.
An unprecedented copper-catalyzed intramolecular radical cyclization was developed for the synthesis of 3-hydroxypyrroloindoline skeletons in excellent yields. The 3-hydroxyl group introduced by trapping intermediate with molecular oxygen or TEMPO. This process represents a unique oxidation pathway tryptamine/tryptophan derivatives and allows rapid biomimetic natural product protubonine A.
A copper-mediated cyclization and dimerization of tryptamine or tryptophan was developed to generate a C2-symmetry C3(sp3)–C3(sp3) bridge with two contiguous stereogenic quaternary carbons in one step. Impressively, the ratio between exo endo products varies when different protecting groups Nb are utilized. This reaction could be conducted gram scale. With this method, both endocyclotryptophan (+)-WIN 64821 exocyclotryptophan (−)-ditryptophenaline were synthesized 5 steps.
Hypercohin A (1), an unprecedented polycyclic polyprenylated acylphloroglucinol featuring with unusual bicyclo[5.3.1]hendecane core, was isolated from Hypericum cohaerens. Its structure and absolute configurations were elucidated by extensive NMR methods crystal X-ray diffractions of its p-bromobenzoate ester (2).
A novel sterically congested Lycopodium alkaloid named lycopalhine (1) that possesses a fused hexacyclic (5/5/5/6/6/6) ring system comprising 5,9-diaza-tricyclo[6.2.1.04,9]undecane moiety and tricyclo[5.2.1.04,8]decane was isolated from Palhinhaea cernua L. The structure absolute configuration were determined by spectroscopic computational methods.
Abstract An enantioselective rhodium(I)‐catalyzed cycloisomerization reaction of challenging (E)‐1,6‐enynes is reported. This novel process enables with a wide range functionalities, including nitrogen‐, oxygen‐, and carbon‐tethered (E)‐1,6‐enynes, to undergo excellent enantioselectivity, in high‐yielding operationally simple manner. Moreover, this Rh I ‐diphosphane catalytic system also exhibited superior reactivity enantioselectivity for (Z)‐1,6‐enynes. A rationale the striking difference...
While nickel-nitrilotriacetic acid (Ni-NTA) has greatly advanced recombinant protein purification, its limitations, including nonspecific binding and partial purification for certain proteins, highlight the necessity additional such as size exclusion ion exchange chromatography. However, specialized equipment FPLC is typically needed but not often available in many laboratories. Here, we show a novel method utilizing polyphosphate (polyP) purifying proteins with histidine repeats via...
Cheliensisin A (Chel A), as a novel styryl-lactone isolated from Goniothalamus cheliensis Hu, has been demonstrated to have an inhibition of EGF-induced Cl41 cell transformation via stabilizing p53 protein in Chk1-dependent manner, suggesting its chemopreventive activity our previous studies. However, underlying molecular mechanisms not fully characterized yet. In the current study, we found that Chel treatment could increase c-Jun phosphorylation and activation, whereas phosphorylation, by...
Cancer metastasis is a complex process involving highly motile tumor cells that breach tissue barriers, enter the bloodstream and lymphatic system, disseminate throughout body as circulating cells. The primary cellular mechanism contributing to these critical events reorganization of actin cytoskeleton. Mycalolide B (MycB) an actin-targeting marine macrolide can suppress proliferation, migration, invasion breast ovarian cancer at low nanomolar doses. Through structure–activity relationship...
Four new terpenoids, metaseglyptorin A (1), metasequoic acid C (2), 12α-hydroxy-8,15-isopimaradien-18-oic (3), and (−)-acora-2,4(14),8-trien-15-oic (4), three norlignans, metasequirins D−F (5−7), were isolated from Metasequoia glyptostroboides, together with 15 known compounds. Structures of the compounds determined by analysis their spectroscopic data, absolute configuration 7 was established modified Mosher method. All evaluated for cytotoxicity against five human tumor cell lines.
The activation of NOD-like receptor family, pyrin domain containing3 (NLRP3) inflammasome has been shown to be positively correlated with the severity proteinuria in chronic kidney disease (CKD) patients. Prostaglandin E2 (PGE2), an important inflammatory mediator, is also involved various injuries. aim present study was investigate involvement NLRP3 and PGE2 synthetic pathway albumin-induced renal tubular injury.Murine proximal cells (mPTCs) were treated albumin induce cell injury. siRNA...
Abstract Transition-metal-catalyzed cycloisomerization of 1,n-allenynes represents a powerful synthetic tool to rapidly assemble complex polycyclic skeletons from simple linear substrates. Nevertheless, there are no reports the asymmetric version these reactions. Moreover, most reactions proceed through 6-endo-dig cyclization pathway, which preferentially delivers distal product (via 5/5 rhodacyclic intermediate) rather than proximal one 6/5 intermediate). Herein, we report an...
With the outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), coronaviruses have begun to attract great attention across world. Of known human coronaviruses, however, Middle East coronavirus (MERS-CoV) is most lethal. Coronavirus proteins can be divided into three groups: nonstructural proteins, structural and accessory proteins. While number each these varies greatly among different are closely related pathogenicity virus. We found for first time that ORF3 protein...
Inhibition of autophagy has been widely viewed as a promising strategy for anticancer therapy. However, few effective and specific inhibitors have reported. Herein, we described the design, synthesis, biological characteristics new analogues strigolactones (SLs), an emerging class plant hormones, against colorectal cancers. Among them, enantiopure analogue 6 exerted potent selective cytotoxicity cancer cells, but not normal human colon mucosal epithelial which were further confirmed by plate...
Meisoindigo (Mei) has long been recognized in chronic myeloid leukemia (CML) treatment. To elucidate its molecular target and mechanisms, we embarked on designing synthesizing a series of Mei-derived PROTACs. Through this endeavor, VHL-type PROTAC 9b was identified to be highly cytotoxic against SW620, SW480, K562 cells. Employing DiaPASEF-based quantitative proteomic analysis, combination with extensive validation assays, unveiled that potently selectively degraded ATM across SW620 SW480...
6/6/6/6/5 Pentacyclic steroids represent an emerging class of architecturally unique and biologically promising steroids. Herein, we developed a DDQ-mediated dehydrogenative Diels–Alder/aromatization cascade reaction between ergosterol derivatives dienophiles inspired by plausible biosynthetic pathways, which enabled straightforward access to various pentacyclic in 24–66% yields. This work offers significant advantages assembling such as the use inexpensive starting materials, mild...
Przewalskone (1), an unprecedented adduct of two different terpenoid units via a hetero-Diels–Alder cycloaddition, was isolated from the roots Salvia przewalskii. The structure and absolute configurations were elucidated by extensive analysis NMR spectra crystal X-ray diffractions. Compound 1 exhibited significant cytotoxicities against five human cancer lines in vitro (IC50 0.69–2.35 μM).